2,4-dicyano-3-methylbenzeneamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dicyano-3-methylbenzeneamine
• 英文别名: 4-Amino-2-methylisophthalonitrile；4-amino-2-methylbenzene-1,3-dicarbonitrile
• 化学式: C₉H₇N₃
• 分子量: 157.175
• InChiKey: NEOFDHIXEGTQDF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  73.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-dicyano-3-methylbenzeneamine 生成 2,4-二氨基-5-甲基喹唑啉-6-甲腈
  参考文献：
  名称：

  BERMAN, ELLEN M.;SUTO, MARK J.

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-dibromo-3-methyl(15N)aniline;hydrochloride 以68的产率得到2,4-dicyano-3-methylbenzeneamine
  参考文献：
  名称：

  J. Labelled. Compd. Rad. 1991, 29, 415-429

  摘要：

  DOI：

文献信息

• Substituted benzonitriles
  申请人：Warner-Lambert Company

  公开号：US04677219A1

  公开（公告）日：1987-06-30

  An improved process for the preparation of 6-substituted-5-alkyl-2,4-quinazolinediamines, useful in the production of trimetrexate and similar antifolate agents, together with several novel intermediates are disclosed.

  揭示了一种改进的工艺，用于制备6-取代-5-烷基-2,4-喹唑啉二胺，可用于生产曲美曲塞和类似的抗叶酸类药物，同时还揭示了几种新的中间体。
• Process for preparing 5,6-substituted-2,4-quinazolinediamines and intermediates
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0253396A2

  公开（公告）日：1988-01-20

  An improved process for the preparation of 6-substituted-5-­alkyl-2,4-quinazolinediamines, useful in the production of trimetrexate and similar antifolate agents, together with several novel intermediates are disclosed.

  本发明公开了一种改进的 6-取代-5-烷基-2,4-喹唑啉二胺制备工艺以及几种新型中间体，该工艺可用于生产曲美曲塞特和类似的抗叶酸制剂。
• COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE
  申请人：Flagship Pioneering Innovations V, Inc.

  公开号：US20210289794A1

  公开（公告）日：2021-09-23

  The invention comprises methods for decreasing colonization by a bacterium of a gut of a stink bug, the method comprising providing a composition comprising vanillin or an analog thereof; and delivering said composition to an egg from which the stink bug will hatch, whereby colonization by the bacterium within the gut of the stink bug hatched from the egg treated with the composition is decreased relative to a stink bug hatched from an untreated egg. In some embodiments, the decrease in colonization by the bacterium decreases the fitness of the stink bug, e.g., decreases reproductive ability, survival, rate of development, number of eggs, number of hatched eggs, adult emergence rate, body length, body width, body mass, or cuticle thickness. In some embodiments of the methods herein, the bacterial colonization-disrupting agent is an inhibitor of bacterial metabolism. In some embodiments, the bacterial colonization-disrupting agent is a polyhydroxyalkanoate (PHA) synthesis inhibitor.
• US4677219A
  申请人：——

  公开号：US4677219A

  公开（公告）日：1987-06-30