benzoate-succinic ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzoate-succinic ester
• 英文别名: 4-Benzoyloxy-4-oxobutanoic acid
• 化学式: C₁₁H₁₀O₅
• 分子量: 222.197
• InChiKey: OGNWKUFBAJNOAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  80.7
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  benzoate-succinic ester 在 水 、 sodium hydride 、 potassium carbonate 、 三乙胺 、 三氟乙酸 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 反应 12.5h， 生成 (2R,3R,4S)-3-acetamido-4-[[amino(benzamido)methylidene]amino]-2-[(1R,2R)-1,2,3-trihydroxypropyl]-3,4-dihydro-2H-pyran-6-carboxylic acid
  参考文献：
  名称：

  Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities

  摘要：

  我们合成了一系列酰基胍修饰的扎那米韦类似物，并评估了它们对禽流感病毒（H1N1 和 H3N2）NAs 的抑制活性。其中，具有疏水性萘取代基的扎那米韦衍生物 3j 对 1 组 NA 的抑制活性最佳，IC50 为 20 nM。

  DOI：

  10.1039/c3ob40624e

文献信息

• [EN] IMMEDIATE-RELEASE ABUSE DETERRENT COMPOSITIONS OR MEDICAMENTS FOR TREATING PAIN, ADD, ADHD AND OTHER SYNDROMES OR DISORDERS<br/>[FR] COMPOSITIONS ANTI-ABUS À LIBÉRATION IMMÉDIATE OU MÉDICAMENTS DESTINÉS AU TRAITEMENT DE LA DOULEUR, DU DCA, DU TDAH, ET D'AUTRES SYNDROMES OU TROUBLES
  申请人：KEMPHARM INC

  公开号：WO2018071879A1

  公开（公告）日：2018-04-19

  The presently described technology provides one or more compositions, preferably one or more immediate-release profile compositions, comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5- alpha-epoxy-3-methoxy-17-methyl), or chemically conjugated to hydromorphone (4,5,α-epoxy-3-hydroxy-17-methyl morphinan-6-one), in combination with at least one gel forming polymer; at least one disintegrant; and at least one surfactant to form novel compositions which have a decreased potential for abuse. The hydrocodone conjugate can also be combined with an analgesic, such as acetaminophen, to form a combinatorial composition that includes at least one gel forming polymer; at least one disintegrant; and at least one surfactant. The present technology also provides pharmaceutical kits and methods of synthesizing conjugates of the present technology.

  目前描述的技术提供了一种或多种组合物，最好是一种或多种立即释放剖面组合物，其中含有与羟考酮（吗啡-6-酮，4,5-α-环氧-3-甲氧基-17-甲基）或与羟吗啡（4,5,α-环氧-3-羟基-17-甲基吗啡-6-酮）化学结合的芳基羧酸，结合至少一种凝胶形成聚合物；至少一种崩解剂；和至少一种表面活性剂，以形成具有减少滥用潜力的新型组合物。羟考酮结合物还可以与镇痛剂（如对乙酰氨基酚）结合，形成包括至少一种凝胶形成聚合物；至少一种崩解剂；和至少一种表面活性剂的组合物。该技术还提供了药物配套组和合成本技术结合物的方法。
• A process for preparing a polyarylene thioether
  申请人：IDEMITSU PETROCHEMICAL CO. LTD.

  公开号：EP0281036A2

  公开（公告）日：1988-09-07

  A process for preparing a polyarylene thioether, which comprises polymerizing a thiophenol having the formula (I) and/or a diphenyldisulfide having the formula (II) wherein R are substituents selected from the group consisting of hydrogen atoms, lower alkyl groups, halogen atoms and lower alkoxy, the groups R may be different from or identical with each other, in the presence of a Lewis acid as a catalyst.

  一种制备聚芳基硫醚的工艺，包括在路易斯酸作为催化剂的存在下，聚合具有式（I）的噻吩酚和/或具有式（II）的二苯基二硫醚，其中 R 是选自氢原子、低级烷基、卤素原子和低级烷氧基组成的组的取代基，基团 R 可以彼此不同或相同。
• Process for producing urethan foam having high-density skin layer
  申请人：TOSOH CORPORATION

  公开号：EP0559216A1

  公开（公告）日：1993-09-08

  A process is provided for producing a polyurethane foam having a high-density skin layer by reacting a polyol with a polyisocyanate in a short time. The reaction is allowed to proceed in the presence of a blowing agent, a catalyst, and optionally an additive, the blowing agent being composed only of water, and the catalyst being an amine represented by the general formula (I) below and/or an organic acid salt thereof: where R₁, R₂, R₃, and R₄ represent independently an alkyl group of 1 to 12 carbons, or R₁ and R₂, and/or R₃ and R₄ may be linked to form a (cycloalkyl, or heterocyclic) ring together with the adjacent nitrogen atom; and R₅ is hydrogen, an alkyl group of 1 to 12 carbons, a phenyl group, or a cycloalkyl group. This process does not use any halogenated hydrocarbon which causes ozone layer destruction.

  本发明提供了一种通过使多元醇与多异氰酸酯在短时间内发生反应来生产具有高密度表 皮层的聚氨酯泡沫塑料的工艺。反应在发泡剂、催化剂和可选添加剂的存在下进行，其中发泡剂仅由水组成，催化剂为以下通式（I）表示的胺和/或其有机酸盐： 其中 R₁、R₂、R₃ 和 R₄ 独立地代表 1 至 12 个碳原子的烷基，或 R₁ 和 R₂，和/或 R₃ 和 R₄ 可与相邻的氮原子连接形成一个（环烷基或杂环）环；R₅ 是氢、1 至 12 个碳原子的烷基、苯基或环烷基。该工艺不使用任何会破坏臭氧层的卤代烃。
• NOVEL PROCESS FOR PREPARATION OF DULOXETINE HYDROCHLORIDE
  申请人：Lupin Limited

  公开号：EP2132192B1

  公开（公告）日：2013-04-24
• Highly concentrated minoxidil composition
  申请人：Stiefel Research Australia Pty Ltd

  公开号：EP1695708B1

  公开（公告）日：2018-02-28