3-(4-chlorophenoxy)-4-chlorophenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(4-chlorophenoxy)-4-chlorophenol
• 英文别名: 4-Chloro-3-(4 chlorophenoxy)phenol；4-chloro-3-(4-chlorophenoxy)phenol
• 化学式: C₁₂H₈Cl₂O₂
• 分子量: 255.1
• InChiKey: NKXQKZCJUVTWQL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氯苯酚 在 双氧水 作用下， 以 aq. phosphate buffer 为溶剂， 反应 2.0h， 生成 2-(4-chlorophenoxy)-4-chlorophenol 、 3-(4-chlorophenoxy)-4-chlorophenol 、 2-(4-chlorophenoxy)-1,4-benzenediol 、 对苯二酚 、 对苯醌
  参考文献：
  名称：

  Enzymatic removal of chlorophenols using horseradish peroxidase immobilized on superparamagnetic Fe3O4/graphene oxide nanocomposite

  摘要：

  Magnetic Fe3O4 nanoparticles were successfully deposited on graphene oxide sheets by ultrasound-assisted coprecipitation. The nanoparticles were characterized using transmission electron microscopy, vibrating sample magnetometry, and X-ray photoelectron spectroscopy. The synthesized material was used as a support for the immobilization of horseradish peroxidase (HRP). The removals of 2-chlorophenol, 4-chlorophenol, and 2,4-dichlorophenol using the immobilized HRP were investigated. Batch degradation studies were used to determine the effects of the initial solution pH values, reaction temperature, reaction time, H2O2 and chlorophenol concentrations, and immobilized enzyme dosage on the removal of chlorophenols. The different numbers and positions of electron-withdrawing substituents affected the chlorophenol removal efficiency; the order of the removal efficiencies was 2-chlorophenol < 4-chlorophenol < 2,4-dichlorophenol. The oxidation products formed during chlorophenol degradation were identified using gas chromatography-mass spectrometry. The biochemical properties of the immobilized HRP were investigated; the results indicated that the storage stability and tolerance to changes in pH and temperature of the immobilized HRP were better than those of free HRP. The nanoparticles were recovered using an external magnetic field, and the immobilized HRP retained 66% of its initial activity for the first four cycles, showing that the immobilized HRP had moderate stability. These results suggest that the immobilized enzyme has potential application in wastewater treatment. (C) 2015, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/s1872-2067(15)60856-7

文献信息

• Verfahren zur Herstellung von halogenierten Hydroxydiphenylverbindungen
  申请人：Ciba Specialty Chemicals Holding Inc.

  公开号：EP0857711A1

  公开（公告）日：1998-08-12

  Beschrieben wird ein Verfahren zur Herstellung von Halogen-hydroxydiphenylverbindungen der Formel durch Acylierung einer halogenierten Benzolverbindung (erste Stufe), Veretherung der acylierten Verbindung mit einer halogenierten Phenolverbindung (zweite Stufe), Oxidation der veretherten Verbindung (dritte Stufe) und Hydrolyse der oxidierten Verbindung in einer vierten Stufe entsprechend dem folgenden Reaktionsschema: worin R1 und R2unabhängig voneinander F, Cl oder Br; R3 und R4unabhängig voneinander Wasserstoff; oder C1-C4-Alkyl; m1 bis 3; und n1 oder 2; bedeuten. Die Verbindungen der Formel (1) finden Verwendung zum Schützen von organischen Materialien und Gegenständen vor Mikroorganismen.

  一种制备式中卤代羟基二苯基化合物的工艺 通过卤代苯化合物的酰化反应（第一步）、酰化化合物与卤代苯酚化合物的醚化反应（第二步）、醚化化合物的氧化反应（第三步）和第四步中氧化化合物的水解反应，按以下反应方案制备式中的卤代羟基二苯化合物： 其中 R1 和 R2 独立地为 F、Cl 或 Br； R3 和 R4 独立地为氢；或 C1-C4 烷基； m1至3；以及 n 为 1 或 2； 表示 式（1）化合物用于保护有机材料和物体免受微生物的侵害。
• Enzymatic removal of chlorophenols using horseradish peroxidase immobilized on superparamagnetic Fe3O4/graphene oxide nanocomposite
  作者：Qing Chang、Guodong Jiang、Heqing Tang、Na Li、Jia Huang、Laiyan Wu

  DOI：10.1016/s1872-2067(15)60856-7

  日期：2015.7

  Magnetic Fe3O4 nanoparticles were successfully deposited on graphene oxide sheets by ultrasound-assisted coprecipitation. The nanoparticles were characterized using transmission electron microscopy, vibrating sample magnetometry, and X-ray photoelectron spectroscopy. The synthesized material was used as a support for the immobilization of horseradish peroxidase (HRP). The removals of 2-chlorophenol, 4-chlorophenol, and 2,4-dichlorophenol using the immobilized HRP were investigated. Batch degradation studies were used to determine the effects of the initial solution pH values, reaction temperature, reaction time, H2O2 and chlorophenol concentrations, and immobilized enzyme dosage on the removal of chlorophenols. The different numbers and positions of electron-withdrawing substituents affected the chlorophenol removal efficiency; the order of the removal efficiencies was 2-chlorophenol < 4-chlorophenol < 2,4-dichlorophenol. The oxidation products formed during chlorophenol degradation were identified using gas chromatography-mass spectrometry. The biochemical properties of the immobilized HRP were investigated; the results indicated that the storage stability and tolerance to changes in pH and temperature of the immobilized HRP were better than those of free HRP. The nanoparticles were recovered using an external magnetic field, and the immobilized HRP retained 66% of its initial activity for the first four cycles, showing that the immobilized HRP had moderate stability. These results suggest that the immobilized enzyme has potential application in wastewater treatment. (C) 2015, Dalian Institute of Chemical Physics, Chinese Academy of Sciences. Published by Elsevier B.V. All rights reserved.