2-methyl-3-n-pentyl maleimide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-methyl-3-n-pentyl maleimide
• 英文别名: 2-methyl-3-(n-pentyl)Mi；3-Methyl-4-pentylpyrrole-2,5-dione
• 化学式: C₁₀H₁₅NO₂
• 分子量: 181.235
• InChiKey: YDVUTVLJELNAJA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 chromium(VI) oxide 作用下， 以 二氯甲烷 、 硫酸 、 三氟乙酸 为溶剂， 生成 2-methyl-3-n-pentyl maleimide
  参考文献：
  名称：

  Petroporphyrins—II

  摘要：

  DOI：

  10.1016/0040-4020(80)80174-8

文献信息

• The First Experimental Demonstration of Side Chain Extension of Geoporphyrins in Sediments
  作者：Kenta Asahina、Junya Asano、Gen Kumagai、Mitsuru Satou、Kouichi Nomoto、Yuichiro Kashiyama、Hajime Mita、Shinya Nomoto

  DOI：10.1246/cl.2010.1267

  日期：2010.12.5

  To investigate the formation process of high carbon number (>C32) sedimentary porphyrins, heating experiments of several porphyrins were performed. Chromic acid oxidation of the heating products of protoporphyrin IX dimethyl ester afforded 2-methyl-3-n-propylmaleimide as the predominant product among the side-chain extension products formed. On the other hand, saturated substituents of etioporphyrin were also extended on heating to slowly form normal and branched homologs. These results may suggest that the transalkylation of porphyrin side chains proceeds mainly by a regioselective mechanism involving alkyl radical addition to a vinyl group of chlorophylls or their diagenetic products.

  为了研究高碳数（>C32）沉积卟啉的形成过程，对几种卟啉进行了加热实验。将前卟啉IX二甲酸酯的加热产物进行铬酸氧化，得到了作为主要产物的2-甲基-3-n-丙基马来酰亚胺。此外，乙基卟啉的饱和取代基在加热过程中也被延伸，缓慢形成正常和支链同系物。这些结果可能表明，卟啉侧链的转烷基化主要通过一种区域选择性机制进行，该机制涉及烷基自由基与叶绿素或其成岩产物的乙烯基团的加成反应。
• Citraconimide (co)polymers and curing with anionic catalyst
  申请人：Akzo Nobel N.V.

  公开号：EP0495545A1

  公开（公告）日：1992-07-22

  A process for the preparation of a (co)polymer containing at least one unit derived from a citraconimide by curing curable composition comprising at least one substituted or unsubstituted citraconimide and a sufficient amount of an anionic curing catalyst to convert at least 10% of the citraconic alkyl groups on the citraconimide units to alkylene bridges; at a temperature above the melting point of the citraconimide unit and the product of that curing process, are disclosed. The invention also relates to the cured oligomers and articles of manufacture embodying them. These novel, cured oligomers are thermoplastic and offer several advantageous properties.

  本发明公开了一种制备含有至少一个源自柠康亚胺的单元的（共）聚合物的工艺，其方法是在高于柠康亚胺单元熔点的温度下，固化可固化组合物，该组合物包括至少一个取代或未取代的柠康亚胺和足量的阴离子固化催化剂，以将柠康亚胺单元上至少 10%的柠康烷基转化为亚烷基桥。本发明还涉及固化后的低聚物及其制造品。这些新型固化低聚物是热塑性的，具有多种优势特性。
• RESIN COMPOSITION FOR OPTICAL MATERIAL, RESIN FILM FOR OPTICAL MATERIAL, AND OPTICAL WAVEGUIDE
  申请人：Hitachi Chemical Company, Ltd.

  公开号：EP2045629A1

  公开（公告）日：2009-04-08

  A resin composition for an optical material, which is excellent in heat resistance and transparency and is soluble in an aqueous alkali solution, a resin film for an optical material made of the resin composition, and an optical waveguide using the same are provided. The resin composition for an optical material includes: (A) an alkali-soluble (meth)acrylate polymer containing a maleimide skeleton in a main chain; (B) a polymerizable compound; and (C) a polymerization initiator. The resin film for an optical material is made of the resin composition for an optical material. The optical waveguide has a core part and/or a clad layer formed using the resin composition for an optical material or the resin film for an optical material.

  本发明提供了一种耐热性和透明度优异且可溶于碱水溶液的光学材料用树脂组合物、由该树脂组合物制成的光学材料用树脂膜以及使用该树脂组合物的光波导。光学材料用树脂组合物包括(A) 主链中含有马来酰亚胺骨架的碱溶性（甲基）丙烯酸酯聚合物；(B) 可聚合化合物；以及 (C) 聚合引发剂。光学材料用树脂薄膜由光学材料用树脂组合物制成。光波导具有使用光学材料用树脂组合物或光学材料用树脂薄膜形成的芯部和/或包层。
• PHOTOSENSITIVE RESIN COMPOSITION, CURED PHOTOSENSITIVE RESIN PRODUCT, PHOTOSENSITIVE RESIN FILM, CURED PHOTOSENSITIVE RESIN FILM PRODUCT, AND OPTICAL WAVEGUIDE PRODUCED BY USING THOSE PRODUCTS
  申请人：Hitachi Chemical Company, Ltd.

  公开号：EP2182410A1

  公开（公告）日：2010-05-05

  Provided are a photosensitive resin composition which is soluble in an alkaline aqueous solution and which has a good propagation loss in a visible light wavelength region, a photosensitive resin cured matter, a photosensitive resin film, a photosensitive resin film cured matter and an optical waveguide obtained by using the same. Provided are, to be specific, a photosensitive resin composition comprising (A) a vinyl polymer having at least one chain-polymerizable functional group in a molecule, (B) a polymerizable compound and (C) a polymerization initiator, wherein the component (C) is at least one selected from the group consisting of 2-[2-oxo-2-phenylacetoxyethoxy]ethyl oxyphenylacetate, 2-(2-hydroxyethoxy)ethyl oxyphenylacetate and oligo2-hyroxy-2-methyl-1-[4-(1-methylvinyl)phenyl]}propanone, a photosensitive resin cured matter, a photosensitive resin film, a photosensitive resin film cured matter and an optical waveguide obtained by using the same.

  本发明提供了一种可溶于碱性水溶液且在可见光波长区域具有良好传播损耗的光敏树脂组合物、光敏树脂固化物、光敏树脂薄膜、光敏树脂薄膜固化物以及使用该组合物获得的光波导。 具体地说，提供了一种光敏树脂组合物，该组合物包含（A）分子中至少有一个可链聚官能团的乙烯基聚合物，（B）可聚合化合物和（C）聚合引发剂，其中组分（C）至少选自由 2-[2-氧代-2-苯乙酰氧基乙氧基]氧代苯乙酸乙酯组成的组中的一种、2-(2-羟基乙氧基)乙基氧苯乙酸酯和低聚2-羟基-2-甲基-1-[4-(1-甲基乙烯基)苯基]}丙酮、光敏树脂固化物、光敏树脂薄膜、光敏树脂薄膜固化物和光导波导中的至少一种。
• N-SUBSTITUTED 2,5-DIOXO-AZOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER
  申请人：CanBas Co., Ltd.

  公开号：EP3567035A1

  公开（公告）日：2019-11-13

  Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

  本发明提供了新型取代唑二酮类化合物，可杀死细胞、抑制细胞增殖、抑制细胞生长、减弱细胞周期 G2 检查点和/或导致细胞周期 G2 停滞。本发明还提供了制造和使用本发明化合物的方法。本发明提供了用于治疗细胞增殖障碍的取代唑二酮类化合物。本发明包括使用取代的唑二酮选择性地杀死或抑制癌细胞，而无需额外的抗癌治疗。本发明包括使用细胞周期G2-检查点抑制取代的唑二酮类化合物选择性地使癌细胞对DNA损伤试剂、治疗和/或其它类型的抗癌试剂敏感。