1-(2-benzoylthioethyl)pyrrolidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(2-benzoylthioethyl)pyrrolidine
• 英文别名: S-(2-pyrrolidin-1-ylethyl) benzenecarbothioate
• 化学式: C₁₃H₁₇NOS
• 分子量: 235.35
• InChiKey: PMFXEQAGXOMNDY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  45.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-(2-benzoylthioethyl)pyrrolidine 、 p-nitrobenzyl (5R,6R)-6-((S)-1-hydroxypropyl)-2-methylsulfinylpenem-3-carboxylate 以58%的产率得到p-nitrobenzyl (5R,6R)-6-((S)-1-hydroxypropyl)-2-(2-(pyrrolidin-1-yl)ethyl)thiopenem-3-carboxylate
  参考文献：
  名称：

  PENEM DERIVATIVES AND ANTIMICROBIAL AGENT CONTAINING THE SAME

  摘要：

  公开号：

  EP0757051B1
• 作为产物：
  描述：

  N-(2-羟乙基)-吡咯烷 、 硫代苯甲酸 、 ethyl acetate n-hexane 、 偶氮二甲酸二乙酯 在 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以64%的产率得到1-(2-benzoylthioethyl)pyrrolidine
  参考文献：
  名称：

  PENEM DERIVATIVES AND ANTIMICROBIAL AGENT CONTAINING THE SAME

  摘要：

  公开号：

  EP0757051B1

文献信息

• [EN] 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES<br/>[FR] DERIVES DE 7-ARYL-3,9-DIAZABICYCLO(3.3.1)NON-6-ENE ET LEUR UTILISATION EN TANT QU'INHIBITEURS DE RENINE DANS LE TRAITEMENT DE L'HYPERTENSION, DE MALADIES CARDIOVASCULAIRES OU RENALES
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2003093267A1

  公开（公告）日：2003-11-13

  The invention relates to novel 3,9-diazabicyclo[3.3.1]nonene derivatives of formula (I) and related compounds and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as inhibitors or renin.

  该发明涉及新型3,9-二氮杂双环[3.3.1]壬烯衍生物（I）及相关化合物，以及它们作为药物组合物中活性成分的用途。该发明还涉及相关方面，包括制备这些化合物的过程、含有这些化合物中的一个或多个的药物组合物，尤其是它们作为肾素抑制剂的用途。
• Penem derivatives and antimicrobial agent containing the same
  申请人：Ishiguro Masaji

  公开号：US20050004092A1

  公开（公告）日：2005-01-06

  A penem derivative represented by the following formula (I): wherein R 1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkenyl group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted aryl group, a substituted or unsubstituted alkylthio group, a substituted or unsubstituted alkenylthio group, a substituted or unsubstituted aralkylthio group, a substituted or unsubstituted arylthio group, a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted heterocyclic thio group, a substituted or unsubstituted acylthio group, a mercapto group or a hydrogen atom, and R 2 represents a hydrogen atom or a carboxyl-protecting group; or a pharmacologically acceptable salt thereof. The compound (I) exhibits strong antibacterial activities, and especially, shows strong activities against MRSA. It is therefore useful not only as a general antibacterial agent but also as an antibacterial agent for MRSA against which no general antibacterial agents are recognized to be-effective.

  以下是公式（I）所代表的一种青霉烷衍生物： 其中，R1代表取代或未取代的烷基、取代或未取代的烯基、取代或未取代的芳基烷基、取代或未取代的芳基、取代或未取代的烷基硫基、取代或未取代的烯基硫基、取代或未取代的芳基烷基硫基、取代或未取代的芳基硫基、取代或未取代的杂环基、取代或未取代的杂环硫基、取代或未取代的酰基硫基、巯基或氢原子，R2代表氢原子或羧酸保护基；或其药学上可接受的盐。该化合物（I）表现出强大的抗菌活性，特别是对MRSA表现出强大的活性。因此，它不仅有用作一般抗菌剂，还有用作抗MRSA的抗菌剂，对于这种细菌，一般的抗菌剂被认为无效。
• Immunostimulatory nucleic acid molecules
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：EP1714969A2

  公开（公告）日：2006-10-25

  Nucleic acid sequences containing unmethylated CpG dinucleotides that modulate an immune response including stimulating a Th1 pattern of immune activation, cytokine production, NK lytic activity, and B cell proliferation are disclosed. The sequences are also useful as synthetic adjuvant.

  本研究公开了含有未甲基化 CpG 二核苷酸的核酸序列，这些核酸序列可调节免疫反应，包括刺激 Th1 型免疫激活、细胞因子产生、NK 吞噬活性和 B 细胞增殖。这些序列还可用作合成佐剂。
• Use of unmethylated CpG oligonucleotides for the treatment of allergy
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：EP2322615A1

  公开（公告）日：2011-05-18

  An immuostimulatory nucleic acid containing an unmethylated CpG dinucleotide for use in a method of treating or preventing an allergy in a subject, wherein an effective dose of the immunostimulatory nucleic acid alone is to be administered to the subject.

  一种含有未甲基化 CpG 二核苷酸的免疫刺激核酸，用于治疗或预防受试者过敏症的方法，其中免疫刺激核酸单独施用给受试者的有效剂量。
• Immunostimulatory nucleic acid molecules comprising GTCGTT motifs
  申请人：UNIVERSITY OF IOWA RESEARCH FOUNDATION

  公开号：EP2360252A1

  公开（公告）日：2011-08-24

  An isolated immunostimulatory oligonucleotide comprising two or more unmethylated CpG dinucleotides, and having a sequence including the following formula:         5'N1X1X2CGTTN23' wherein the immunostimulatory oligonucleotide includes a modified backbone, at least one nucleotide separates consecutive CpGs, X1X2 is GpT or ApT, N1 is any nucleotide that includes a 5' TC or TG, N1 + N2 is from 0-26 bases, and the immunostimulatory oligonucleotide is from 8-30 bases in length and begins with TC or TG at the 5' end, with the proviso that neither N1 nor N2 contains a CCGG quadmer or more than one CCG or CGG trimer.

  一种分离的免疫刺激寡核苷酸，包含两个或多个未甲基化的 CpG 二核苷酸，其序列包括下式： 5'N1X1X2CGTTN23' 其中，免疫刺激寡核苷酸包括修饰的骨架，至少有一个核苷酸将连续的 CpGs 分开，X1X2 是 GpT 或 ApT，N1 是包括 5' TC 或 TG 的任何核苷酸，N1 + N2 是 0-26 个碱基、免疫刺激寡核苷酸长度为 8-30 个碱基，5'端以 TC 或 TG 开头，但 N1 和 N2 均不包含 CCGG 四聚体或一个以上的 CCG 或 CGG 三聚体。