N-palmitoyl-vanillamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-palmitoyl-vanillamide
• 英文别名: N-hexadecanoyl-4-hydroxy-3-methoxybenzamide
• 化学式: C₂₄H₃₉NO₄
• 分子量: 405.578
• InChiKey: HOXAPJDPLOCBKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  29
• 可旋转键数：
  16
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  香兰素胺盐酸盐 、 棕榈酰氯 在 N-甲基吗啉 、 盐酸 作用下， 以 N-甲基乙酰胺 、 甲基叔丁基醚 、 氯仿 、 水 为溶剂， 以91%的产率得到N-palmitoyl-vanillamide
  参考文献：
  名称：

  PHARMACOLOGICAL PREPARATION FOR TOPICAL USE CONTAINING N-PALMITOYL-VANILLAMIDE

  摘要：

  本发明涉及含有具有高痛觉敏感活性的N-棕榈酰基香草酰胺的局部制剂。具体而言，本发明涉及将N-棕榈酰基香草酰胺用于治疗以下病理选择：带状疱疹后神经痛，三叉神经痛，枕神经痛，牙痛神经痛，咽喉返神经痛，尿毒症神经痛，糖尿病神经痛，不同起源的头痛，神经病性瘙痒，神经源性瘙痒，尿毒症瘙痒，外阴疼痛，外阴前庭炎，肛门疼痛和瘙痒，包皮龟头疼痛和瘙痒，犬和猫的疼痛性泌尿生殖系统疾病，牛皮癣相关的瘙痒和疼痛，人类和兽医领域的瘙痒性皮肤病（例如特应性皮炎），肌肉疼痛，肌腱疼痛，人类、犬和猫的骨关节炎相关疼痛，人类和兽医领域的眼部疾病疼痛，人类和兽医领域的口腔炎症病理学。

  公开号：

  US20120115808A1

文献信息

• Pharmacological preparation for topical use containing n-palmitoyl-vanillamide
  申请人：Epitech Group S.r.l.

  公开号：EP2455066A1

  公开（公告）日：2012-05-23

  The present invention relates to a topical preparation containing N-palmitoyl-vanillamide with antihyperalgic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of a pathology selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottofaryngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rettal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.

  本发明涉及一种含有具有抗过敏活性的 N-棕榈酰香草酰胺的外用制剂。 特别是，本发明涉及用于治疗以下病症的 N-棕榈酰香草酰胺：带状疱疹后遗神经痛、三叉神经痛、枕叶神经痛、牙神经痛、咽喉神经痛、尿毒症神经痛、糖尿病神经痛、不同原因的头痛、神经性痒、神经源性痒、尿毒症痒、外阴瘙痒、尿毒症性瘙痒、外阴阴道炎、外阴前庭炎、肛门阴道疼痛和瘙痒、肛门阴道疼痛和瘙痒、猫狗泌尿生殖系统疼痛、牛皮癣相关性瘙痒和疼痛、瘙痒性皮肤病（如特应性皮炎）。人和兽医领域的肌肉疼痛、肌腱疼痛、人、狗和猫的骨关节炎相关疼痛；人和兽医领域的疼痛性眼病；人和兽医领域的口腔炎症性病变。
• DEVICE AND FORMULATION FOR TOPICAL TREATMENT OF PAIN AFFECTING THE VULVAR AREA OF THE FEMALE HUMAN GENITAL ORGAN
  申请人：Grünenthal GmbH

  公开号：EP3626230A1

  公开（公告）日：2020-03-25

  The present invention relates to a device for the topical treatment of pain affecting the vulvar area of the female human genital organ, a formulation for use in the device according to the invention, and a kit comprising the device according to the present intention. Additionally, the present invention relates to a method of topical treatment of pain affecting the vulvar area of the female human genital organ, said method using the device according to the present invention. The device is a layered article shaped to be placed in use inside a female undergarment and at least partially in skin contact with the female vulvar area and comprises a topical formulation.

  本发明涉及一种用于局部治疗影响女性人体生殖器官外阴部位疼痛的装置、一种用于本发明装置的配方，以及一种包含本发明装置的试剂盒。此外，本发明还涉及一种局部治疗影响女性人体生殖器官外阴部位疼痛的方法，所述方法使用根据本发明的装置。该装置是一种分层物品，在使用时可置于女性内衣内，至少部分与女性外阴部位的皮肤接触，并包含一种局部配方。
• Device and formulation for topical treatment of pain affecting the vulvar area of the female human genital organ
  申请人：Gruenenthal GmbH

  公开号：US10765848B2

  公开（公告）日：2020-09-08

  The present invention relates to a device for the topical treatment of pain affecting the vulvar area of the female human genital organ, a formulation for use in the device according to the invention, and a kit comprising the device according to the present intention. Additionally, the present invention relates to a method of topical treatment of pain affecting the vulvar area of the female human genital organ, said method using the device according to the present invention. The device is a layered article shaped to be placed in use inside a female undergarment and at least partially in skin contact with the female vulvar area and comprises a topical formulation.

  本发明涉及一种用于局部治疗影响女性人体生殖器官外阴部位疼痛的装置、一种用于本发明装置的配方，以及一种包含本发明装置的试剂盒。此外，本发明还涉及一种局部治疗影响女性人体生殖器官外阴部位疼痛的方法，所述方法使用根据本发明的装置。该装置是一种分层物品，在使用时可置于女性内衣内，至少部分与女性外阴部位的皮肤接触，并包含一种局部配方。
• Pharmacological preparation for topical use containing N-palmitoyl-vanillamide
  申请人：EPITECH GROUP S.p.A.

  公开号：EP2455066B1

  公开（公告）日：2018-10-17
• ION CHANNEL ACTIVATORS AND METHODS OF USE
  申请人：Flex Pharma, Inc.

  公开号：EP3131541A1

  公开（公告）日：2017-02-22