1,3-dimethoxy-5-(1-phenylvinyl)benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-dimethoxy-5-(1-phenylvinyl)benzene
• 英文别名: 1-(3,5-Dimethoxyphenyl)-1-phenylethanol；1-(3,5-dimethoxyphenyl)-1-phenylethanol
• 化学式: C₁₆H₁₈O₃
• 分子量: 258.317
• InChiKey: NLZRBRYPANZWMR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  38.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,3-dimethoxy-5-(1-phenylvinyl)benzene 在 盐酸 作用下， 以 二氯甲烷 、 水 为溶剂， 以0.350 g的产率得到1,3-dimethoxy-5-(1-phenylvinyl)benzene
  参考文献：
  名称：

  Distinctive Meta-Directing Group Effect for Iridium-Catalyzed 1,1-Diarylalkene Enantioselective Hydrogenation

  摘要：

  An iridium-catalyzed asymmetric hydrogenation of 1,1-diarylkenes is described. Employing a novel, modular phosphoramidite ligand, PhosPrOx, in this transformation affords biologically relevant 1,1-diarylmethine products in good enantiomeric ratios (96.5:3.5 to 71:29). We propose that a meta-directing group, 3,5-dimethoxyphenyl, is responsible for the observed enantioselection, the highest reported, to date, for iridium-catalyzed hydrogenation of 1,1-diarylalkenes lacking ortho-directing groups.

  DOI：

  10.1021/ol303465c
• 作为产物：
  描述：

  1-溴-3,5-二甲氧基苯 、 苯乙酮 在 magnesium 、 1,2-二溴乙烷 作用下， 以 四氢呋喃 为溶剂， 反应 2.17h， 生成 1,3-dimethoxy-5-(1-phenylvinyl)benzene
  参考文献：
  名称：

  Distinctive Meta-Directing Group Effect for Iridium-Catalyzed 1,1-Diarylalkene Enantioselective Hydrogenation

  摘要：

  An iridium-catalyzed asymmetric hydrogenation of 1,1-diarylkenes is described. Employing a novel, modular phosphoramidite ligand, PhosPrOx, in this transformation affords biologically relevant 1,1-diarylmethine products in good enantiomeric ratios (96.5:3.5 to 71:29). We propose that a meta-directing group, 3,5-dimethoxyphenyl, is responsible for the observed enantioselection, the highest reported, to date, for iridium-catalyzed hydrogenation of 1,1-diarylalkenes lacking ortho-directing groups.

  DOI：

  10.1021/ol303465c

文献信息

• METHOD FOR IN-SITU FORMATION OF METATHESIS CATALYSTS
  申请人：Schrodi Yann

  公开号：US20130204026A1

  公开（公告）日：2013-08-08

  Synthetic methods for the in-situ formation of olefin metathesis catalysts are disclosed, as well as the use of such catalysts in metathesis reactions of olefins and olefin compounds. In one aspect, a method is provided for synthesizing an organometallic compound of the formula comprising contacting a precursor compound of the formula (X 1 X 2 ML j L 1 k L 3 m ) i with an acetylenic compound comprising a chelating moiety, optionally, in the presence of a neutral electron donor, wherein M is a Group 8 transition metal, L, L 1 , L 2 , and L 3 are neutral electron donors, X 1 and X 2 are anionic ligands, j is 1, 2, or 3; k is zero, 1, or 2; m is zero or 1; n is 1 or 2; and i is an integer; with the proviso that k is zero when the precursor compound is contacted with the acetylenic compound in the presence of the neutral electron donor, and R 1 and R 2 are independently selected from hydrocarbyl, substituted hydrocarbyl, heteroatom-containing hydrocarbyl, substituted heteroatom-containing hydrocarbyl, and functional groups, wherein R 1 and R 2 are linked and together form one or more cyclic groups, R 2 and L 2 are linked and together form one or more cyclic groups, and any other two or more of X 1 , X 2 , L 1 , L 2 , L 3 , R 1 , and R 2 can be taken together to form one or more cyclic groups. The invention has utility in the fields of catalysis, organic synthesis, polymer chemistry, and industrial and fine chemicals chemistry.

  本文披露了用于原位合成烯烃转化催化剂的合成方法，以及在烯烃和烯烃化合物的转化反应中使用这种催化剂的方法。在一方面，提供了一种合成具有以下公式的有机金属化合物的方法： （X1X2MLjL1kL3m）i 其中，M是第8族过渡金属，L、L1、L2和L3是中性电子给体，X1和X2是阴离子配体，j为1、2或3，k为0、1或2，m为0或1，n为1或2，i为整数；但前提是当前体化合物在中性电子给体的存在下与含有螯合基团的乙炔化合物接触时，k为零。R1和R2是烃基、取代烃基、含杂原子的烃基、取代含杂原子的烃基和官能团，其中R1和R2连接在一起形成一个或多个环。R2和L2连接在一起形成一个或多个环，X1、X2、L1、L2、L3、R1和R2中的任意其他两个或更多个可以结合在一起形成一个或多个环。本发明在催化、有机合成、聚合物化学以及工业和精细化学品化学领域具有实用价值。
• US9273081B2
  申请人：——

  公开号：US9273081B2

  公开（公告）日：2016-03-01
• Distinctive <i>Meta</i>-Directing Group Effect for Iridium-Catalyzed 1,1-Diarylalkene Enantioselective Hydrogenation
  作者：Elizabeth N. Bess、Matthew S. Sigman

  DOI：10.1021/ol303465c

  日期：2013.2.1

  An iridium-catalyzed asymmetric hydrogenation of 1,1-diarylkenes is described. Employing a novel, modular phosphoramidite ligand, PhosPrOx, in this transformation affords biologically relevant 1,1-diarylmethine products in good enantiomeric ratios (96.5:3.5 to 71:29). We propose that a meta-directing group, 3,5-dimethoxyphenyl, is responsible for the observed enantioselection, the highest reported, to date, for iridium-catalyzed hydrogenation of 1,1-diarylalkenes lacking ortho-directing groups.