1-o-tolyl-tetrahydro-1H-pyrrolo[1,2-a]imidazole-2,5-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑烷类
• 英文名称: 1-o-tolyl-tetrahydro-1H-pyrrolo[1,2-a]imidazole-2,5-dione
• 英文别名: 1-(2-methylphenyl)-3,6,7,7a-tetrahydropyrrolo[1,2-a]imidazole-2,5-dione
• 化学式: C₁₃H₁₄N₂O₂
• 分子量: 230.266
• InChiKey: QRWIBQDPXGDRCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴甲苯 、 地来西坦 在 N-甲基吡咯烷酮 、 copper(l) iodide 、 potassium carbonate 作用下， 反应 1.0h， 生成 1-o-tolyl-tetrahydro-1H-pyrrolo[1,2-a]imidazole-2,5-dione
  参考文献：
  名称：

  [EN] PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS
  [FR] COMPOSES PRESENTANT UNE ACTION NOOTROPIQUE, LEUR PREPARATION, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, ET LEUR UTILISATION

  摘要：

  公开号：

  WO2004085438A3

文献信息

• Pyrroloimidazole derivatives, their preparation, pharmaceutical composition containing them, and their use as nootropic agents
  申请人：Farina Carlo

  公开号：US20070027137A1

  公开（公告）日：2007-02-01

  Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.

  本文介绍了一种具有神经保护和刺激脑功能、镇痛作用和抗高痛敏作用的新型双环芳基咪唑酮；还描述了它们的制备过程和包含它们的制药组合物，用于治疗认知缺陷和各种类型的疼痛。
• Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof
  申请人：Neurotune AG

  公开号：US07732473B2

  公开（公告）日：2010-06-08

  Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.

  本文描述了一种具有神经保护和刺激脑功能、镇痛和抗高痛敏作用的新型双环芳基咪唑酮；还描述了它们的制备过程和包含它们的药物组合物，用于治疗认知缺陷和各种类型的疼痛。
• Compounds with nootropic action, their preperation, pharmaceutical compositions containing them, and use thereof
  申请人：FARINA Carlo

  公开号：US20090163565A1

  公开（公告）日：2009-06-25

  Described herein are new bicyclic arylimidazolones having nootropic action (i.e., protecting and stimulating cerebral functions), analgesic action and anti hyperalgesic action; also described is the process for their preparation and pharmaceutical compositions comprising them, useful for the treatment of cognitive deficits, and of various types of pain.

  本文描述了一种具有神经保护和刺激脑功能、镇痛和抗高痛敏作用的新型双环芳基咪唑酮；还描述了它们的制备过程和包含它们的药物组合物，可用于治疗认知缺陷和各种类型的疼痛。
• PYRROLOIMIDAZOLE DERIVATIVES, THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE AS NOOTROPIC AGENTS
  申请人：NIKEM RESEARCH S.R.L.

  公开号：EP1608655A2

  公开（公告）日：2005-12-28
• EP1608655B8
  申请人：——

  公开号：EP1608655B8

  公开（公告）日：2008-10-15