cholinium glycolate

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: cholinium glycolate
• 英文别名: choline glycolate；2-hydroxyethyl-trimethylammonium 2-hydroxyethanoate；2-Hydroxyethyl-trimethylammonium 2-hydroxyethanoate；2-hydroxyacetate;2-hydroxyethyl(trimethyl)azanium
• 化学式: C₂H₃O₃*C₅H₁₄NO
• 分子量: 179.216
• InChiKey: JGVSZDFHWNPMMA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.59
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  80.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  羟基乙酸 、 氯化胆碱 在 anion exchange resin Ambersep 900 OH 作用下， 以 水 为溶剂， 生成 cholinium glycolate
  参考文献：
  名称：

  木质素溶解的高效可持续溶剂：胆碱羧酸盐水溶液

  摘要：

  木质素是有前途的化石资源替代品，可用于生产燃料，生物复合材料和增值化学品。为了更好地利用这种自然资源，仍然有必要开发有效的木质素溶剂。因此，在这项工作中，通过向生物来源的胆碱羧酸盐离子液体（ILs）中添加水，已经开发出13种新型木质素溶剂。木质素的溶解度已在25°C下确定为IL含量的函数。系统检查了ILs的阴离子结构对木质素溶解度的影响。发现在这些溶剂中，六种类型的IL在室温下显示出木质素溶解的高效能力。木质素在羧酸根阴离子中的溶解度随烷基链长度的增加而增加，2组以及使用胆碱二-/三羧酸盐会导致木质素溶解度降低，甚至使木质素不溶于溶剂。根据NMR测量，这些结果已通过阴离子羧基的强水合以及阴离子和阳离子的烷基链与木质素的可能相互作用来解释。另外，溶解的木质素可以通过添加额外的水来再生，并且在溶解和再生过程中不会发生化学反应。

  DOI：

  10.1039/c7gc01886j

文献信息

• An integrated high-throughput strategy enables the discovery of multifunctional ionic liquids for sustainable chemical processes
  作者：Anlian Zhu、Lingjun Li、Chi Zhang、Yutan Shen、Mingjie Tang、Lili Bai、Chunyan Du、Suojiang Zhang、Jianji Wang

  DOI：10.1039/c8gc03119c

  日期：——

  high-throughput preparation of ionic liquids and in situ screening of their reaction-promoting performance in 96-well plates. The integrated approach then enables a facile identification of optimal ionic liquids from a 400-ionic liquid candidate pool to act as the solvent, the catalyst and the separating assistant, simultaneously, for carbonyl-azide cycloaddition reactions. Merits of the ionic liquids-based processes

  开发具有简化的反应系统和后处理程序的新化学工艺是一项艰巨的任务。尽管离子液体是简化传统化学过程的一类潜在的多功能化合物，但是由于复杂的相互作用，它们的合理设计仍然很困难。在这项工作中，提出了一种概念验证策略，以实现离子液体的高通量制备和原位集成。在96孔板中筛选其促进反应的性能。然后，该集成方法可以轻松地从400个离子液体候选物库中识别出最佳离子液体，以同时充当羰基叠氮化物环加成反应的溶剂，催化剂和分离助剂。基于离子液体的方法的优点不仅在方便，高效地合成1,2,3-三唑基化合物中得到了证明，而且还在发现用于化学后修饰游离肽的新反应的过程中得到了证明。
• Design of environmentally friendly ionic liquid aqueous two-phase systems for the efficient and high activity extraction of proteins
  作者：Zhiyong Li、Xinxin Liu、Yuanchao Pei、Jianji Wang、Mingyuan He

  DOI：10.1039/c2gc35890e

  日期：——

  Ionic liquids (ILs) have numerous applications in industrial processes as a benign alternative to conventional volatile organic solvents. However, many of them are toxic to organisms and are poorly biodegradable. In this work, a series of environmentally friendly cholinium ILs have been designed and synthesized. It was found that these ILs could form aqueous two-phase systems (ATPSs) with polypropylene glycol 400 (PPG400) which is thermo-sensitive, non-toxic and biodegradable. In order to understand the phase formation processes and possible application of these ATPSs for extraction/separation of proteins, the binodal curves and tie lines of these ATPSs were measured at 25 °C, and the effects of anionic structure of the ionic liquids, nature of the proteins and difference in the concentration of top- and bottom-phases on the partitioning behavior of some typical proteins were investigated systematically. It was shown that bovine serum albumin (BSA), trypsin, papain and lysozyme could be enriched effectively into the ionic liquid-rich phase of the ATPSs, and single-step extraction efficiency could be as high as 86.4–99.9% under the optimized conditions. Furthermore, enzyme activity of the native trypsin in water and in aqueous ionic liquid solutions was determined by using N-a-benzoyl-L-arginine ethyl ester as a substrate, and activity increases to about 127% was observed after 13 months storage. In addition, PPG400 has been recovered simply by heating and reused in the next extraction processes. This avoids the non-sustainable issue of highly salty water produced in the application of the polyethylene glycol (PEG) + salt and ionic liquid + salt ATPSs.

  离子液体(ILs)作为常规挥发性有机溶剂的环保替代品，在工业过程中有着广泛的应用。然而，许多离子液体对生物体具有毒性且难以生物降解。在本工作中，设计和合成了一系列环境友好的胆碱类离子液体。研究发现，这些离子液体与热敏、无毒且可生物降解的聚丙二醇400(PPG400)可以形成水相双离子液体体系(ATPSs)。为了理解这些ATPSs的相形成过程及其在蛋白质提取/分离中的可能应用，在25 °C下测量了这些ATPSs的双结曲线和系线，并系统地研究了离子液体阴离子结构、蛋白质性质以及上相和下相浓度差异对一些典型蛋白质分配行为的影响。结果表明，牛血清白蛋白(BSA)、胰蛋白酶、木瓜蛋白酶和溶菌酶可以有效地富集到ATPSs的离子液体富集相中，在优化条件下单步提取效率可高达86.4-99.9%。此外，使用N-苯甲酰-L-精氨酸乙酯作为底物，测定了水和水合离子液体溶液中天然胰蛋白酶的酶活性，经过13个月的储存后活性增加到约127%。此外，PPG400通过简单加热即可回收并在下一次提取过程中重复使用。这避免了在应用聚乙二醇(PEG)+盐和离子液体+盐ATPSs时产生的高盐水量不可持续的问题。
• [EN] IONIC LIQUIDS FOR DRUG DELIVERY<br/>[FR] LIQUIDES IONIQUES POUR L'ADMINISTRATION DE MÉDICAMENTS
  申请人：HARVARD COLLEGE

  公开号：WO2021102084A1

  公开（公告）日：2021-05-27

  The technology described herein is directed to ionic liquids and methods of drug delivery.

  本技术涉及离子液体及药物输送方法。
• Cholinium-based Supported Ionic Liquid Membranes: A Sustainable Route for Carbon Dioxide Separation
  作者：Liliana C. Tomé、David J. S. Patinha、Rui Ferreira、Helga Garcia、Cristina Silva Pereira、Carmen S. R. Freire、Luís Paulo N. Rebelo、Isabel M. Marrucho

  DOI：10.1002/cssc.201300613

  日期：2014.1

  Aiming at full sustainability of CO2 separation processes, a series of supported ionic liquid membranes based on environmentally friendly cholinium carboxylate ionic liquids were successfully prepared. Their gas permeation properties were measured and high permselectivities were obtained for both CO2/CH4 and CO2/N2.

  针对CO 2分离过程的完全可持续性，成功制备了一系列基于环境友好的羧酸羧酸胆碱离子液体的负载型离子液体膜。测量了它们的气体渗透性能，并获得了CO 2 / CH 4和CO 2 / N 2的高选择性。
• High concentration DNA solubility in bio-ionic liquids with long-lasting chemical and structural stability at room temperature
  作者：Mukesh Sharma、Dibyendu Mondal、Nripat Singh、Nitin Trivedi、Jitkumar Bhatt、Kamalesh Prasad

  DOI：10.1039/c5ra03512k

  日期：——

  DNA (Salmon testes) was solubilized in a biocompatible ionic liquid at up to 8 wt% with long term (one year) structural and chemical stability upon storage at room temperature.

  DNA（鲑鱼睾丸）在生物相容性离子液体中可溶解达到最高8 wt％，并在室温下储存长达一年的结构和化学稳定性。