1-methyl-2-(5-methyl-4-formyl-2-furyl)-1H-benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 1-methyl-2-(5-methyl-4-formyl-2-furyl)-1H-benzimidazole
• 英文别名: 2-Methyl-5-(1-methylbenzimidazol-2-yl)furan-3-carbaldehyde
• 化学式: C₁₄H₁₂N₂O₂
• 分子量: 240.261
• InChiKey: HQQZOBMBAKOGQF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  乌洛托品 、 1-甲基-2-(5'-甲基-2'-呋喃基)苯并咪唑 在 PPA 作用下， 反应 4.0h， 以67%的产率得到1-methyl-2-(5-methyl-4-formyl-2-furyl)-1H-benzimidazole
  参考文献：
  名称：

  Synthesis of aldehydes and ketones of 1-methyl-2-(5-methyl-2-hetaryl)-1H-benzimidazole series

  摘要：

  1-Methyl-2-(5-methyl-2-furyl)-1H- and 1-methyl-2-(5-methyl-2-thienyl)-1H-benzimidazoles were synthesized by Weidenhagen reaction followed by N-methylation. The obtained 1H-benzimidazoles were formylated with hexamethylenetetramine in polyphosphoric acid and acylated with carboxylic acids in polyphosphoric acid.

  DOI：

  10.1134/s107036321504012x

文献信息

• Synthesis of aldehydes and ketones of 1-methyl-2-(5-methyl-2-hetaryl)-1H-benzimidazole series
  作者：M. M. El’chaninov、A. A. Aleksandrov、I. M. El’chaninov

  DOI：10.1134/s107036321504012x

  日期：2015.4

  1-Methyl-2-(5-methyl-2-furyl)-1H- and 1-methyl-2-(5-methyl-2-thienyl)-1H-benzimidazoles were synthesized by Weidenhagen reaction followed by N-methylation. The obtained 1H-benzimidazoles were formylated with hexamethylenetetramine in polyphosphoric acid and acylated with carboxylic acids in polyphosphoric acid.