2-(3-pyridyl)-9-fluorenone

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2-(3-pyridyl)-9-fluorenone
• 英文别名: 2-Pyridin-3-ylfluoren-9-one
• 化学式: C₁₈H₁₁NO
• 分子量: 257.291
• InChiKey: FYTLKPWUFHOAHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-溴-9-芴酮 、 二乙基(3-吡啶基)-硼烷 在 氢氧化钾 、 四(三苯基膦)钯 、 四丁基溴化铵 作用下， 以 四氢呋喃 为溶剂， 反应 18.0h， 以20%的产率得到2-(3-pyridyl)-9-fluorenone
  参考文献：
  名称：

  Inhibition of Myeloperoxidase Release from Rat Polymorphonuclear Leukocytes by a Series of Azachalcone Derivatives

  摘要：

  A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes stimulated by fMLP. The compounds were found to interfere with cellular uptake of extracellular calcium. Structure-activity relationships are discussed.

  DOI：

  10.1021/jm00051a013

文献信息

• Inhibition of Myeloperoxidase Release from Rat Polymorphonuclear Leukocytes by a Series of Azachalcone Derivatives
  作者：Michael L. Edwards、David M. Stemerick、Jeffrey S. Sabol、Keith A. Diekema、Robert J. Dinerstein

  DOI：10.1021/jm00051a013

  日期：1994.12

  A series of azachalcones was evaluated for ability to affect secretion of myeloperoxidase by rat polymorphonuclear leukocytes stimulated by fMLP. The compounds were found to interfere with cellular uptake of extracellular calcium. Structure-activity relationships are discussed.