anti-3-Methyl-2-phenylpentanoic acid

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: anti-3-Methyl-2-phenylpentanoic acid
• 英文别名: 3-methyl-2-phenylpentenoic acid；(2R,3R)-3-methyl-2-phenylpentanoic acid
• 化学式: C₁₂H₁₆O₂
• 分子量: 192.258
• InChiKey: NQVALZRLGIRTKX-MWLCHTKSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (E)-2-phenyl-3-methyl-2-pentenoic acid 在 (R)-N-methyl-N-<2-(4-morpholino)ethyl>-<1-(S)-1',2-bis(diphenylphosphino)ferrocenyl>ethylamine 氢气 作用下， 以 异丙醇 为溶剂， 反应 100.0h， 生成 (2S,3S)-3-Methyl-2-phenyl-pentanoic acid 、 anti-3-Methyl-2-phenylpentanoic acid
  参考文献：
  名称：

  Asymmetric hydrogenation of trisubstituted acrylic acids catalyzed by a chiral (aminoalkyl)ferrocenylphosphine-rhodium complex

  摘要：

  DOI：

  10.1021/ja00259a043

文献信息

• Regioselective Alkylation of Lithium Dienediolates of α,β-Unsaturated Carboxylic Acids
  作者：Eva M. Brun、Salvador Gil、Ramón Mestres、Margarita Parra

  DOI：10.1055/s-2000-6323

  日期：——

  Lithium carboxylic acids dienediolates are regioselectively alkylated at the α-carbon by reaction with tosylates derived from both primary and secondary alcohols. Both regio- and diastereoselectivity are improved when compared with those obtained in the corresponding alkylation with alkyl halides.

  锂羧酸二烯二醇化物在反应中与由伯醇和仲醇衍生的甲磺酸酯作用，能区域选择性地在α-碳位进行烷基化。与相应的烷基卤代物进行烷基化反应相比，无论是区域选择性还是立体选择性都有所提高。
• Lithium enediolates and dienediolates of carboxylic acids in synthesis: Alkylation with secondary halides
  作者：Eva M. Brun、Salvador Gil、Ramón Mestres、Margarita Parra

  DOI：10.1016/s0040-4020(98)00957-0

  日期：1998.12

  High yields in the alkylation of dianions of alpha,beta-unsaturated carboxylic acids with secondary halides can be obtained despite elimination reactions occurring. alpha-Regioselectivity for the alkylation of but-2-enoic acids (1-4) is seldom obtained. Although double bond stereoselectivity is higher than 99% for gamma-alkylated products, stereoselectivity is rather poor for most of the alpha-alkylated products. (C) 1998 Elsevier Science Ltd. AII rights reserved.