4-chloro-benzene sulphonyl chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-benzene sulphonyl chloride
• 英文别名: m-chlorobenzene sulphonyl chloride；3-chlorobenzene sulphonyl chloride；4-chlorobenzene sulfonyl chloride；p-chlorobenzene sulfonyl chloride；3-chlorobenzene sulfonyl chloride；Chlorobenzene;sulfuryl dichloride
• 化学式: C₆H₅Cl*Cl₂O₂S
• 分子量: 247.529
• InChiKey: ZMCOWIJJSXOLAZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.05
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-chloro-benzene sulphonyl chloride 以98%的产率得到1,3-二氯苯
  参考文献：
  名称：

  Process for preparing M-chlorobenzene sulphonyl chloride

  摘要：

  Meta-氯苯磺酰氯和间二氯苯是通过在Friedel-Crafts催化剂存在下，在0°C至150°C的温度下，将苯磺酰氯和氯反应制备的。除去催化剂后，所得的m-氯苯磺酰氯被反应成m-二氯苯。在反应成m-二氯苯之前，最好先将m-氯苯磺酰氯分离出来。形成m-二氯苯的反应可以通过热解、热氯解或光化学或自由基引发的氯解来进行。

  公开号：

  US04012442A1

文献信息

• Bis-Acylated Hydroxylamine Derivatives
  申请人：Toscano John P.

  公开号：US20110136827A1

  公开（公告）日：2011-06-09

  The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the invention provides methods of using such compounds or pharmaceutical compositions for treating, preventing, or delaying the onset and/or develop of a disease or condition. In some embodiments, the disease or condition is selected from cardiovascular diseases, ischemia, reperfusion injury, cancerous disease, pulmonary hypertension and conditions responsive to nitroxyl therapy.

  这项发明提供了某些双酰化羟胺衍生物化合物，包括这些化合物的药物组合物和试剂盒，以及使用这些化合物或药物组合物的方法。具体而言，该发明提供了使用这些化合物或药物组合物治疗、预防或延缓疾病或病况发生和/或发展的方法。在某些实施例中，疾病或病况可选自心血管疾病、缺血、再灌注损伤、癌症疾病、肺动脉高压和对亚硝酰治疗有反应的病况。
• [EN] A PROCESS FOR THE MANUFACTURE OF POSACONAZOLE<br/>[FR] PROCÉDÉ DE FABRICATION DE POSACONAZOLE
  申请人：METROCHEM API PVT LTD

  公开号：WO2019077627A1

  公开（公告）日：2019-04-25

  The present invention discloses an improved process for the manufacture of Posaconazole, an anti-fungal agent belonging to the category of substituted Tetrahydrofuran Triazole compound. The present invention further describes preparation of formula A and formula B, the key intermediates in the preparation of Posaconazole. The invention also discloses novel intermediates that are useful in the synthesis of Posaconazole.

  本发明公开了一种改进的制备波沙康唑的方法，波沙康唑是一种属于替代四氢呋喃三唑化合物类别的抗真菌药物。本发明进一步描述了制备波沙康唑的关键中间体方程式A和方程式B的方法。该发明还公开了在波沙康唑合成中有用的新型中间体。
• Dihydroindole and tetrahydroquinoline derivatives
  申请人：——

  公开号：US20030004156A1

  公开（公告）日：2003-01-02

  The present invention relates to novel dihydroindole and tetrahydroquinoline derivatives and pharmaceutically acceptable salts and/or pharmaceutically acceptable esters thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3-oxidosqualene-lanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

  本发明涉及新颖的二氢吲哚和四氢喹啉衍生物以及其药学上可接受的盐和/或药学上可接受的酯。这些化合物可用于治疗和/或预防与2,3-氧化甾醇-鲍甲酚合酶相关的疾病，如高胆固醇血症、高脂血症、动脉硬化、血管疾病、真菌病、胆结石、肿瘤和/或过度增生性疾病，以及治疗和/或预防糖耐量受损和糖尿病。
• Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
  申请人：Link T. James

  公开号：US20050277647A1

  公开（公告）日：2005-12-15

  The present invention relates to compounds which are inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme. The present invention further relates to the use of inhibitors of 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme for the treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, and other diseases and conditions that are mediated by excessive glucocorticoid action.

  本发明涉及抑制11-β-羟基类固醇脱氢酶1型酶的化合物。本发明还涉及利用11-β-羟基类固醇脱氢酶1型酶的抑制剂治疗非胰岛素依赖型2型糖尿病、胰岛素抵抗、肥胖、脂质紊乱、代谢综合征以及其他由过度糖皮质激素作用介导的疾病和症状。
• [EN] HETEROCYCLIC COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSES HETEROCYCLIQUES ET METHODES D'UTILISATION
  申请人：TARGEGEN INC

  公开号：WO2006024034A1

  公开（公告）日：2006-03-02

  Heterocyclic compounds derived from benzotriazine, triazines, triazoles and oxadiazoles are disclosed. The methods of synthesis and of use of such heterocyclic compounds are also provided.

  源自苯并三唑啉、三唑、三唑醇和噁二唑的杂环化合物已被披露。还提供了这些杂环化合物的合成和使用方法。