2-methyl-3,4,5,6-tetrafluorobenzyl alcohol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-methyl-3,4,5,6-tetrafluorobenzyl alcohol
• 英文别名: 2,3,4,5-tetrafluoro-6-methylbenzyl alcohol；(2,3,4,5-Tetrafluoro-6-methylphenyl)methanol
• 化学式: C₈H₆F₄O
• 分子量: 194.129
• InChiKey: MVILTIVROIYUPZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-[2-(1,1-dimethylethyl)pyrimidin-5-yl]-3,3-dimethylbutanoic acid 、 2-methyl-3,4,5,6-tetrafluorobenzyl alcohol 生成 2-methyl-3,4,5,6-tetrafluorobenzyl (RS)-2-[2-(1,1-dimethylethyl)pyrimidin-5-yl]-3,3-dimethylbutanoate
  参考文献：
  名称：

  MCDONALD, EDWARD;SALMON, ROGER;WHITTLE, ALAN JOHN;HUTCHINGS, MICHAEL GORD+

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3,4,5-tetrafluoro-6-methylbenzoic acid 生成 2-methyl-3,4,5,6-tetrafluorobenzyl alcohol
  参考文献：
  名称：

  PUNJA, NAZIM

  摘要：

  DOI：

文献信息

• Process for producing cyclopropanecarboxylates
  申请人：——

  公开号：US20020151741A1

  公开（公告）日：2002-10-17

  There is disclosed a process process for producing a cyclopropanecarboxylate of formula (1): 1 which process comprises reacting cyclopropanecarboxylic acid of formula (2): 2 with a monohydroxy compound of formula (3): R 6 OH  (3), in the presence of a catalyst compound comprising an element of to Group 4 of the Periodic Table of Elements.

  披露了一种制备公式(1)所示的环丙烷甲酸酯的方法：1该方法包括将公式(2)所示的环丙烷甲酸与公式(3)所示的单一羟基化合物反应：R6OH  (3)，在含有元素周期表第4族元素的催化剂化合物存在下。
• Process for Producing 3-(2-Cyano-1-propenyl)-2,2- Dimethylcyclopropanecarboxylic Acid or Salt Thereof
  申请人：Uekawa Toru

  公开号：US20120016150A1

  公开（公告）日：2012-01-19

  A process for producing comprising reacting a 3-formyl-2,2-dimethylcyclopropanecarboxylate and propionitrile in the presence of a base to obtain 3-(2-cyano-1-propenyl)-2,2-dimethylcyclopropanecarboxylic acid or its salt.

  生产过程包括在碱的存在下，通过将3-甲酰基-2,2-二甲基环丙基羧酸酯和丙腈反应，得到3-(2-氰丙烯基)-2,2-二甲基环丙基羧酸或其盐。
• Fluoro alcohols and insecticidal esters thereof
  申请人：Imperial Chemical Industries PLC

  公开号：US04714790A1

  公开（公告）日：1987-12-22

  The invention concerns a process for preparing 2-substituted-3,4,5,6-tetrafluorobenzyl alcohols by reaction of pentafluorobenzyl alcohol with a Grignard reagent under specified conditions. The products some of which are novel are useful as intermediates for insecticidal esters e.g. those with pyrethroid acids. A typical ester is 2-methyl-3,4,5,6-tetrafluorobenzyl 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropane carboxylate.

  该发明涉及一种通过在指定条件下将五氟苯甲醇与格氏试剂反应制备2-取代-3,4,5,6-四氟苄醇的方法。其中一些产品是新颖的，并可用作杀虫酯的中间体，例如与拟除虫酸形成的酯类。典型的酯是2-甲基-3,4,5,6-四氟苄基3-(2-氯-3,3,3-三氟丙-1-烯-1-基)-2,2-二甲基环丙烷羧酸酯。
• Process for the preparation of carboxylic acid esters
  申请人：Souda Hiroshi

  公开号：US20050113581A1

  公开（公告）日：2005-05-26

  There is provided a process for preparing a carboxylic acid ester of formula (3): R 2 COOR 1 (3) wherein R 1 is an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, an aralkyl group which may be substituted, or a heteroarylalkyl group which may be substituted, and R 2 is an alkyl group which may be substituted, an alkenyl group which may be substituted, an alkynyl group which may be substituted, an aryl group which may be substituted, a heteroaryl which may be substituted, an aralkyl group which may be substituted, or a heteroarylalkyl group which may be substituted, which process is characterized by the steps of reacting a monohydroxy compound of formula (1): R 1 OH   (1) wherein R 1 is as defined above, with a zirconium compound of formula (6): Zr(OR 8 ) 4 (6) wherein R 8 is an alkyl group or an aryl group which may be substituted and is not the same as R 1 , to prepare a zirconium catalyst, and reacting a carboxylic acid of formula (2): R 2 COOH   (2) wherein R 2 is as defined above, with the monohydroxy compound of formula (1) in the presence of the zirconium catalyst.

  提供了一种制备化学式为(3)的羧酸酯的方法：R2COOR1 (3)，其中R1是可以被取代的烷基、可以被取代的烯基、可以被取代的炔基、可以被取代的芳基或可以被取代的杂芳基烷基，R2是可以被取代的烷基、可以被取代的烯基、可以被取代的炔基、可以被取代的芳基、可以被取代的杂芳基、可以被取代的芳基烷基或可以被取代的杂芳基烷基。该方法的特征在于将化学式为(1)的单羟基化合物：R1OH (1)（其中R1如上定义）与化学式为(6)的锆化合物反应：Zr(OR8)4 (6)（其中R8是可以被取代的烷基或芳基，且不同于R1），制备锆催化剂，然后在锆催化剂存在的情况下，将化学式为(2)的羧酸：R2COOH (2)（其中R2如上定义）与化学式为(1)的单羟基化合物反应。
• Process for producing fluorinated methyl-benzyl alcohol
  申请人：——

  公开号：US20040010167A1

  公开（公告）日：2004-01-15

  An object of the present invention is to provide a process for producing a fluorinated methyl-benzyl alcohol, which process is industrially practicable. A process for producing a fluorinated methyl-benzyl alcohol according to the present invention comprises hydrogenolysis of one hydroxyl group in fluorinated benzene dimethanol.

  本发明的目的是提供一种生产氟化甲基苯甲醇的工艺，该工艺在工业上是可行的。根据本发明，生产氟化甲基苯甲醇的工艺包括对氟化苯二甲醇中的一个羟基进行氢解反应。