4-methyl-N-{2-[(2-{[(4-methylphenyl)sulfonyl]amino}benzylidene)amino]phenyl}benzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-methyl-N-{2-[(2-{[(4-methylphenyl)sulfonyl]amino}benzylidene)amino]phenyl}benzenesulfonamide
• 英文别名: 2-N-tosylamine(2'-tosylaminobenzal)aniline；2-(tosylamino)-N-[2-(tosylamino)benzylidene]aniline
• 化学式: C₂₇H₂₅N₃O₄S₂
• 分子量: 519.645
• InChiKey: FLDBNMYJUMAXDQ-TURZUDJPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.66
• 重原子数：
  36.0
• 可旋转键数：
  8.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  104.7
• 氢给体数：
  2.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  4-methyl-N-{2-[(2-{[(4-methylphenyl)sulfonyl]amino}benzylidene)amino]phenyl}benzenesulfonamide 、 镉 在 Et₄NClO₄ 作用下， 以 甲醇 为溶剂， 生成
  参考文献：
  名称：

  Direct electrochemical synthesis of novel transition metal chelates of tridentate azomethinic ligands

  摘要：

  New chelates of the type ML(L-1)(n). MeOH (n = 1, 2) were obtained on the basis of the tridentate azomethinic ligands 2-N-tosylamine(2'-hydroxybenzal)aniline (L) and 2-N-tosylamine(2'-tosylaminobenzal)aniline (L-1) and zero-valent transition metals (Co, Ni, Cu, Zn, Cd) under electrosynthesis conditions. The mononuclear character of these products and the participation of N2O- or N-3 groups of the azomethinic Ligands in the coordination are demonstrated by IR, H-1 NMR spectral and magnetic data (77-293 K). (C) 1999 Elsevier Science Ltd, All rights reserved.

  DOI：

  10.1016/s0277-5387(98)00383-0
• 作为产物：
  描述：

  邻氨基苯甲酸甲酯 在 吡啶 、 二异丁基氢化铝 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 3.5h， 生成 4-methyl-N-{2-[(2-{[(4-methylphenyl)sulfonyl]amino}benzylidene)amino]phenyl}benzenesulfonamide
  参考文献：
  名称：

  [EN] BENZENE SULFONAMIDE-BASED INHIBITORS OF SPHINGOSINE KINASE
  [FR] INHIBITEURS DE LA SPHINGOSINE KINASE À BASE DE BENZÈNE-SULFONAMIDES

  摘要：

  揭示了一类新型的鞘氨醇激酶（SK）抑制剂化合物，这些化合物对癌症和其他增殖细胞病症的治疗具有用处。这些化合物是苯磺酰胺，其化学结构符合公式（I）。

  公开号：

  WO2016007993A1

文献信息

• Synthesis and Characterization of Homoleptic and Heteroleptic Cobalt, Nickel, Copper, Zinc and Cadmium Compounds with the 2‐(Tosylamino)‐ <i>N</i> ‐[2‐(tosylamino)benzylidene]aniline Ligand
  作者：Antonio Sousa‐Pedrares、Joaquin A. Viqueira、Jorge Antelo、Elena Labisbal、Jaime Romero、Antonio Sousa、Otaciro R. Nascimento、José A. García‐Vázquez

  DOI：10.1002/ejic.201001356

  日期：2011.5

  The electrochemical oxidation of anodic metal (cobalt, nickel, copper, zinc and cadmium) in an acetonitrile solution of the Schiff-base ligand 2-(tosylamino)-N-[2-(tosylamino)benzylidene]aniline (H2L) afforded the homoleptic compounds [ML]. The addition of 1,1-diphenylphosphanylmethane (dppm), 2,2′-bipyridine (bipy) or 1,10-phenanthroline (phen) to the electrolytic phase gave the heteroleptic complexes

  在席夫碱配体 2-(甲苯磺酰氨基)-N-[2-(甲苯磺酰氨基)亚苄基]苯胺 (H2L) 的乙腈溶液中，阳极金属（钴、镍、铜、锌和镉）的电化学氧化提供了均配物化合物 [ML]。将 1,1-二苯基膦酰甲烷 (dppm)、2,2'-联吡啶 (bipy) 或 1,10-菲咯啉 (phen) 添加到电解相中得到杂配复合物 [NiL(dppm)]、[ML(bipy) ] 和 [ML(phen)]。H2L (1), [NiL] (2), [CuL] (3), [NiL(dppm)] (4), [CoL(phen)] (5), [CuL(bipy)] ( 6) 和 [Zn(Lphen)] (7) 通过 X 射线衍射测定。均质化合物 [NiL] 和 [CuL] 是单核的，具有扭曲的方形平面 [MN3O] 几何形状，席夫碱充当双离子 (NamideNamideNimineOtosyl) 四齿配体。这两种化合物
• Sphingoid compounds for prophylaxis and/or therapy of a viral infection
  申请人：Harbins Ruhr Bioscience, Inc.

  公开号：US10688065B2

  公开（公告）日：2020-06-23

  Provided are processes for the prevention or treatment of viral infection in a subject. Some aspects provide administration of a sphingoid compound, optionally sphingosine, an active ingredient that activates generation of a sphingoid base, optionally of sphingosine; or an active agent that inhibits the degradation of a sphingoid base, optionally of sphingosine, to a subject such as a human. By increasing the local concentration of sphingosine in a subject or an area of a subject to which the composition is administered such as the nose or interior of the nose or portion thereof, the ability of viruses to infect the subject or cells thereof is reduced thereby treating of preventing infection by the virus.

  本文提供了预防或治疗受试者病毒感染的方法。某些方面提供了向人等受试者施用鞘氨醇化合物（可选鞘氨醇）、激活生成鞘氨醇基（可选鞘氨醇）的活性成分；或抑制鞘氨醇基（可选鞘氨醇）降解的活性剂。通过增加施用组合物的受试者或受试者的局部（如鼻子或鼻子内部或其部分）的鞘氨醇浓度，可降低病毒感染受试者或其细胞的能力，从而达到预防病毒感染的目的。
• Sphingoid compounds for prophylaxis and/or therapy of coronaviridae infection
  申请人：Harbins Ruhr Bioscience, Inc.

  公开号：US11298412B2

  公开（公告）日：2022-04-12

  Provided are processes for the prevention or treatment of infection by SARS-CoV-2. Some aspects provide administration of a sphingoid compound, optionally sphingosine, an active ingredient that activates generation of a sphingoid base, optionally of sphingosine; or an active agent that inhibits the degradation of a sphingoid base, optionally of sphingosine, to a subject such as a human. By increasing the local concentration of sphingosine in a subject or an area of a subject to which the composition is administered such as the airways, nose or interior of the nose or portion thereof, the ability or SARS-CoV-2 to infect the subject or cells thereof is reduced thereby treating of preventing infection by the virus.

  本文提供了预防或治疗 SARS-CoV-2 感染的方法。某些方面提供了对人等受试者施用鞘氨醇化合物（可选鞘氨醇）、激活鞘氨醇基（可选鞘氨醇）生成的活性成分；或抑制鞘氨醇基（可选鞘氨醇）降解的活性剂。通过增加受试者或受试者施用组合物的部位（如呼吸道、鼻腔或鼻腔内部或其部分）的鞘氨醇的局部浓度，可降低 SARS-CoV-2 感染受试者或其细胞的能力，从而起到预防病毒感染的作用。
• Burlov; Garnovskii; Kuznetsova, Russian Journal of Coordination Chemistry, 1998, vol. 24, # 12, p. 857 - 860
  作者：Burlov、Garnovskii、Kuznetsova、Volbushko、Korshunov、Asmaev、Kharisov、Blanco、Garnovskii

  DOI：——

  日期：——
• Electrochemical synthesis of adducts of 2-aminopyridine or methanol in metal chelates of a N,N,N-tridentate Schiff base ligand. X-ray crystal structures of the Ni(II) and Zn(II) derivatives
  作者：D.A. Garnovskii、M.F.C. Guedes da Silva、M.N. Kopylovich、A.D. Garnovskii、J.J.R. Fraústo da Silva、A.J.L. Pombeiro

  DOI：10.1016/s0277-5387(03)00104-9

  日期：2003.5

  The electrochemical syntheses of series of novel adducts of 2-aminopyridine and methanol in Co(II), Ni(II), Cu(II) or Zn(II) chelates of the N,N,N-tridentate basic form of the Schiff base 2-N-tosylamino(2'-tosylaminobenzylidene)aniline (H2L), [M(L)L'] (M = Co, Ni, Zn, L' = 2-aminopyridine; M = Cu, L' = CH3OH), were performed by using the corresponding metal as a sacrificial anode. The compounds were characterized by elemental analysis, IR spectroscopy, FAB mass spectrometry, H-1 NMR and magnetic measurements. The crystal structures of the Zn and Ni derivatives as well as of the Schiff base have been determined by X-ray diffraction. In the 2-aminopyridine complexes this ligand is bound to the metal through the endocyclic nitrogen whereas the aminogroup is involved in intramolecular N-(HO)-O-... hydrogen bonds with one of the tosyl SO2 groups. (C) 2003 Elsevier Science Ltd. All rights reserved.