trans-δ-viniferin

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: trans-δ-viniferin
• 英文别名: 5-[(E)-2-[(2S,3S)-3-(3,5-dihydroxyphenyl)-2-(4-hydroxyphenyl)-2,3-dihydro-1-benzofuran-6-yl]ethenyl]benzene-1,3-diol
• 化学式: C₂₈H₂₂O₆
• 分子量: 454.479
• InChiKey: FZGMUGGGYRYYQW-LPGNHZEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  110
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  白藜芦醇 在 secretome isolated from Botrytis cinerea culture 作用下， 以 水 、 丙酮 为溶剂， 反应 5.0h， 以1.2 mg的产率得到restrytisol B
  参考文献：
  名称：

  Generation of Antifungal Stilbenes Using the Enzymatic Secretome of Botrytis cinerea

  摘要：

  The protein secretome of Botrytis cinerea was used to perform the biotransformation of resveratrol, pterostilbene, and a mixture of both. Metabolite profiling by UHPLC-HRMS revealed the presence of compounds with unusual molecular formula, suggesting the existence of new products. To isolate these products, the reactions were scaled up, and 21 analogues were isolated and fully characterized by NMR and HRESIMS analyses. The reaction with pterostilbene afforded five new compounds, while the reaction with-a mixture Of pterostilbene and resveratrol afforded seven unusual stilbene dimers: The antifungal propertieS of these compounds were evaluated using in vitro bioassays against Plasmopara viticola. The cytological effects of the isolated antifungal compounds on the ultrastructure of P. viticola were also evaluated.

  DOI：

  10.1021/acs.jnatprod.6b00760

文献信息

• Generation of Antifungal Stilbenes Using the Enzymatic Secretome of <i>Botrytis cinerea</i>
  作者：Katia Gindro、Sylvain Schnee、Davide Righi、Laurence Marcourt、Samad Nejad Ebrahimi、Josep Massana Codina、Francine Voinesco、Emilie Michellod、Jean-Luc Wolfender、Emerson Ferreira Queiroz

  DOI：10.1021/acs.jnatprod.6b00760

  日期：2017.4.28

  The protein secretome of Botrytis cinerea was used to perform the biotransformation of resveratrol, pterostilbene, and a mixture of both. Metabolite profiling by UHPLC-HRMS revealed the presence of compounds with unusual molecular formula, suggesting the existence of new products. To isolate these products, the reactions were scaled up, and 21 analogues were isolated and fully characterized by NMR and HRESIMS analyses. The reaction with pterostilbene afforded five new compounds, while the reaction with-a mixture Of pterostilbene and resveratrol afforded seven unusual stilbene dimers: The antifungal propertieS of these compounds were evaluated using in vitro bioassays against Plasmopara viticola. The cytological effects of the isolated antifungal compounds on the ultrastructure of P. viticola were also evaluated.