28-hydroxy-14,17,22,25-tetraoxa-1,9,11-triazatricyclo<9.8.8.1^3,7>octacosa-3,5,7(28)-trien-8-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 大环内酰胺类
• 英文名称: 28-hydroxy-14,17,22,25-tetraoxa-1,9,11-triazatricyclo<9.8.8.1^3,7>octacosa-3,5,7(28)-trien-8-one
• 英文别名: 28-Hydroxy-14,17,22,25-tetraoxa-1,9,11-triazatricyclo[9.8.8.13,7]octacosa-3(28),4,6-trien-8-one
• 化学式: C₂₁H₃₃N₃O₆
• 分子量: 423.51
• InChiKey: PBIFJALXYXUWQA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  30
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N,N-双(甲氧基甲基)二氮-18-冠-6 、 水杨酰胺 以 苯 为溶剂， 反应 12.0h， 以34%的产率得到28-hydroxy-14,17,22,25-tetraoxa-1,9,11-triazatricyclo<9.8.8.1^3,7>octacosa-3,5,7(28)-trien-8-one
  参考文献：
  名称：

  A New Approach to the Synthesis of Phenol-Containing Macroheterocycles

  摘要：

  A one-step method for the synthesis of new phenol-containing cryptands and cryptohemispherands by treating N,N'-bis(methoxymethyl)diazacrowns with the appropriate bis- and trisphenols is reported. This method, based on a special Mannich reaction, gives cyclized products without-the need for protecting groups and high dilution conditions. Unusually high yields of cryptohemisherands were realized using a relatively high concentration of the starting materials (50 mmol/L) and in the absence of metal cations as template agents in the reaction mixture. These excellent yields can be explained by intramolecular hydrogen bonding which prevents polycondensation. This new method also allowed preparation of new phenol-containing cylindrical tricyclic ligands by first forming bisphenol-substituted diaza-18-crown-6 at 80 degrees C followed by its reaction with a second bis(methoxymethyl)-substituted diaza-18-crown-6 at 144 degrees C. Crystal structures of two cryptohemispherands are reported herein. A shorter internal distance between N and O atoms in 27 as compared to 6 (R = NO2, n = m = 2) indicates intramolecular hydrogen bonding in phenol-containing macrocycle 27.

  DOI：

  10.1021/jo00120a040

文献信息

• A New Approach to the Synthesis of Phenol-Containing Macroheterocycles
  作者：Andrei V. Bordunov、Nikolai G. Lukyanenko、Victor N. Pastushok、Krzysztof E. Krakowiak、Jerald S. Bradshaw、N. Kent Dalley、Xiaolan Kou

  DOI：10.1021/jo00120a040

  日期：1995.7

  A one-step method for the synthesis of new phenol-containing cryptands and cryptohemispherands by treating N,N'-bis(methoxymethyl)diazacrowns with the appropriate bis- and trisphenols is reported. This method, based on a special Mannich reaction, gives cyclized products without-the need for protecting groups and high dilution conditions. Unusually high yields of cryptohemisherands were realized using a relatively high concentration of the starting materials (50 mmol/L) and in the absence of metal cations as template agents in the reaction mixture. These excellent yields can be explained by intramolecular hydrogen bonding which prevents polycondensation. This new method also allowed preparation of new phenol-containing cylindrical tricyclic ligands by first forming bisphenol-substituted diaza-18-crown-6 at 80 degrees C followed by its reaction with a second bis(methoxymethyl)-substituted diaza-18-crown-6 at 144 degrees C. Crystal structures of two cryptohemispherands are reported herein. A shorter internal distance between N and O atoms in 27 as compared to 6 (R = NO2, n = m = 2) indicates intramolecular hydrogen bonding in phenol-containing macrocycle 27.