5-Methylpyridine-2,4(1H,3H)-dione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-Methylpyridine-2,4(1H,3H)-dione
• 英文别名: 5-methyl-1H-pyridine-2,4-dione
• 化学式: C₆H₇NO₂
• mdl: MFCD18811981
• 分子量: 125.127
• InChiKey: FXKUDVJUXMNPAW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• PROPARGYL SUBSTITUTED NUCLEOSIDE COMPOUNDS AND METHODS
  申请人：ROSENBLUM Barnett B.

  公开号：US20100113759A1

  公开（公告）日：2010-05-06

  The present teachings relate to nucleobase, nucleoside and nucleotide compounds, methods of synthesis, and uses thereof. The present teachings provide compounds, such as nucleobase, nucleoside and/or nucleotide compounds including a propargyl linker, and methods for making or using such compounds.

  本教学涉及核碱基，核苷和核苷酸化合物，其合成方法和用途。本教学提供化合物，如包括丙炔基连接器的核碱基，核苷和/或核苷酸化合物，以及制备或使用这些化合物的方法。
• PREPARATION AND ISOLATION OF 5' CAPPED MRNA
  申请人：Kore Anilkumar

  公开号：US20120156751A1

  公开（公告）日：2012-06-21

  The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool for identifying RNA-protein interactions. Such capped RNA finds use in therapeutic applications, diagnosis and prognosis and in the treatment of cancers and HIV.

  本文考虑到带有帽子/标签的RNA的合成、使用方法以及提供该RNA的工具包。带标签的RNA可以在体外分离RNA转录本。分离和纯化带有帽子的RNA的能力导致了改善转录和翻译，并提供了识别RNA-蛋白质相互作用的工具。这种带有帽子的RNA可用于治疗应用、诊断和预后以及治疗癌症和HIV。
• Propargyl Substituted Nucleoside Compounds and Methods
  申请人：ROSENBLUM Barnett B.

  公开号：US20120309953A1

  公开（公告）日：2012-12-06

  Disclosed, among other things, are compounds having the structure wherein X comprises a bond or a linker, LABEL comprises at least one detectable label, W 1 taken alone is —H or —OH, W 2 is —OH or a non-extendable moiety, W 3 when taken alone is —H or when taken together with W 1 is —CH 2 —O—, and W 4 is OH, monophosphate, diphosphate, or triphosphate. Also disclosed are labeled polynucleotide compounds and methods of use thereof.

  公开的东西包括以下结构的化合物：其中X包括一个键或一个连接物，LABEL包括至少一个可检测的标记，W1单独为-H或-OH，W2为-OH或不可延伸的基团，W3单独为-H或与W1一起为-CH2-O-，W4为OH、单磷酸、二磷酸或三磷酸。还公开了带标记的多核苷酸化合物及其使用方法。
• AGENTS THAT PREVENT OR REPAIR SKIN DAMAGE
  申请人：Regents of the University of Minnesota

  公开号：US20140350036A1

  公开（公告）日：2014-11-27

  The invention provides compounds of formula I: or a salt thereof as described herein. The invention also provides dermatological compositions comprising a compound of formula I or mixtures of one or more compounds of formula I, processes for preparing compounds of formula I, intermediates useful for preparing compounds of formula I and therapeutic methods for protecting skin or DNA from photodamage or repairing photodamaged skin or DNA.

  本发明提供了以下式I的化合物：或其盐，如本文所述。本发明还提供了包含式I化合物或一种或多种式I化合物的混合物的皮肤学组合物，制备式I化合物的方法，用于制备式I化合物的中间体以及保护皮肤或DNA免受光损伤或修复光损伤皮肤或DNA的治疗方法。
• Preparation And Isolation of 5' Capped mRNA
  申请人：KORE Anilkumar

  公开号：US20100304389A1

  公开（公告）日：2010-12-02

  The synthesis of capped/tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool for identifying RNA-protein interactions. Such capped RNA finds use in therapeutic applications, diagnosis and prognosis and in the treatment of cancers and HIV.

  本发明涉及带帽/标记RNA的合成、使用方法和提供相同的试剂盒。标记RNA允许在体外分离RNA转录本。能够分离和纯化带帽RNA使得转录和翻译得到改善，并提供了一种识别RNA-蛋白质相互作用的工具。这种带帽RNA在治疗应用、诊断和预后以及治疗癌症和HIV方面有用。