tribromoneopentyl alcohol

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: tribromoneopentyl alcohol
• 英文别名: trisbromoneopentyl alcohol；1,1,3-tribromo-2,2-dimethylpropan-1-ol
• 化学式: C₅H₉Br₃O
• 分子量: 324.838
• InChiKey: HFRIZVDRQKQDRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tribromoneopentyl alcohol 在 三氯化铝 anhydrous phosphorus trichloride 、 三氯氧磷 作用下， 以 甲醇 、 水 、 邻二氯苯 为溶剂， 以99.9%的产率得到TTBrNP
  参考文献：
  名称：

  US6204404

  摘要：

  公开号：

文献信息

• Flame retardant compounds
  申请人：FMC CORPORATION (UK) LIMITED

  公开号：EP0549023A3

  公开（公告）日：1993-08-11

  The invention provides flame retardant esters of the formula I where Ar represents phenyl, naphthyl, or two aryl rings either directly connected or linked via -CH2-. -CH=CH-. -CHBr- CHBr-. -S-. orX is Cl or Br, preferably Br; m is 3 or 4; and n is 0 to 6; there being two of the ester groups in the ortho position to each other.

  该发明提供了公式I的阻燃酯类化合物，其中Ar代表苯基、萘基或两个芳基环，它们可以直接连接或通过-CH2-、-CH=CH-、-CHBr-、-S-连接，或者X为Cl或Br，优选Br；m为3或4；n为0至6；其中有两个酯基在相对位置。
• Tribromoneopentyl phosphorus reactive flame retardants
  申请人：Stauffer Chemical Company

  公开号：US04049754A1

  公开（公告）日：1977-09-20

  Compounds of the formula: [(BrCH.sub.2).sub.3 CCH.sub.2 O].sub.2 P(O)R wherein R is a functional group selected from the group consisting of --CH.dbd.CH.sub.2,--CH.sub.2 X, --OR'OC(O)CH.dbd.CH.sub.2, --OR'OC(O)C(CH.sub.3).dbd.CH.sub.2, --O(R'O).sub.n H, --OH, --Cl, and NR"R"', wherein R' is a C.sub.1 -C.sub.4 alkylene group, wherein R" and R"' are the same or different and are selected from the group consisting of hydrogen, lower alkyl, e.g. C.sub.1 -C.sub.8, preferably C.sub.1 -C.sub.4, phenyl, hydroxyalkyl, e.g., hydroxy C.sub.1 -C.sub.8, or, preferably hydroxy C.sub.1 -C.sub.4, and allyl groups, wherein X is selected from the group consisting of chlorine and bromine and wherein n is an integer between 1 and 20 are disclosed. These compounds have flame retardancy characteristics and are useful either as flame retardant additives or as reactive flame retardants which can react to confer durable flame retardancy on textiles or other polymer products.

  化合物的公式为：[(BrCH.sub.2).sub.3 CCH.sub.2 O].sub.2 P(O)R，其中R是从以下组合中选择的功能基团：--CH.dbd.CH.sub.2，--CH.sub.2 X，--OR'OC(O)CH.dbd.CH.sub.2，--OR'OC(O)C(CH.sub.3).dbd.CH.sub.2，--O(R'O).sub.n H，--OH，--Cl和NR"R"'，其中R'是C.sub.1-C.sub.4烷基，其中R"和R"'相同或不同，选择自氢，低烷基（例如C.sub.1-C.sub.8，优选C.sub.1-C.sub.4），苯基，羟基烷基（例如羟基C.sub.1-C.sub.8，或更优选羟基C.sub.1-C.sub.4）和烯丙基基团，其中X选择自氯和溴，n是介于1和20之间的整数。这些化合物具有阻燃特性，既可用作阻燃添加剂，也可用作反应性阻燃剂，可通过反应在纺织品或其他聚合物制品上赋予耐久的阻燃性。
• Haloneopentyl Bis(ALKYL) Phosphate Ester, Flame Retardant Composition Containing Same and Polyurethane Foam Prepared Therewith
  申请人：Guo Yinzhong

  公开号：US20100174007A1

  公开（公告）日：2010-07-08

  A haloneopentyl dialkylphosphate ester possesses the general formula wherein each X is Br or Cl, provided at least two of X are Br, and R 1 and R 2 each independently is alkyl of up to 12 carbon atoms.

  一种haloneopentyl dialkylphosphate酯具有一般公式，其中每个X是Br或Cl，只要至少有两个X是Br，R1和R2各自独立地是最多12个碳原子的烷基。
• pH-Responsive Fe₃O₄ Nanopartilces-Capped Mesoporous Silica Supports for Protein Delivery
  作者：Qi Gan、Jiaoyang Zhu、Yuan Yuan、Changsheng Liu

  DOI：10.1166/jnn.2016.11744

  日期：2016.6.1

  Delivery of proteins and peptides with excellent bioactivity and controlled release still is a great challenge nowadays. In this study, a pH-responsive delivery system obtained by anchoring 8-nm Fe3O4 nanoparticles (NPs) onto SBA-15 supports with a particle diameter in the range of 0.6-1 mu m and a pore size of 6.2 nm was synthesized and investigated. The pH-stimulative response is based on the interaction between the tris(aminomethyl) ethane (TAE) groups anchored onto the pore outlet of mesoporous silica scaffolds and the carboxybenzaldehyde (CBA) groups coated on the Fe3O4 NPs, which can lead to a rapid release under the acid condition (pH=5) and a zero release with the increase of pH value (pH = 7.4). With BMP-2 as a model protein, this Fe3O4 nanopartilces-capped mesoporous silica showed a rapid response to the change of pH for protein delivery. Furthermore, the released BMP-2 could still maintain its bioactivity and induce the osteoblast differentiation of BMSCs. Besides, the magnetic orientation mainly attributes to the Fe3O4 NPs served as the nanocaps. The excellent bio-compatibility is demonstrated by the MTT assay on BMSCs model cells. These results show that Fe3O4 NPs-capped SBA-15 materials have an effective load for large molecule size proteins, such as BMP-2, and show an excellent applied prospect in pH-responsive controlled release system.
• US6204404
  申请人：——

  公开号：——

  公开（公告）日：——