1-(4-aminophenyl)-3-(2-nitrophenyl)urea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-aminophenyl)-3-(2-nitrophenyl)urea
• 英文别名: N-(4-azaniumylphenyl)-N'-(2-nitrophenyl)carbamimidate
• 化学式: C₁₃H₁₂N₄O₃
• 分子量: 272.263
• InChiKey: SVUGMSACZCCQNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-aminophenyl)-3-(2-nitrophenyl)urea 、 己二酰氯 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以93%的产率得到N¹,N⁶-bis(4-(3-(2-nitrophenyl)ureido)phenyl)adipamide
  参考文献：
  名称：

  Bis amide-aromatic-ureas—highly effective hydro- and organogelator systems

  摘要：

  A series of hydro- and organo-supergelators have been synthesised via coupling of simple bis aromatic-ureas via alkyl amide linkages. These bis amide-aromatic-ureas exhibited reduced critical gelator concentrations, improved gelator stability, mechanical and dye removal properties for potential use in water purification, in comparison to related bis aromatic-ureas. Systematic structure studies via variation of the bis amide-aromatic-urea linker length as well as functionalization of the terminal aromatic moieties have enabled control over the gel properties. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.09.017
• 作为产物：
  描述：

  异腈酸2-硝基苯 、 对苯二胺 以 四氢呋喃 为溶剂， 以89%的产率得到1-(4-aminophenyl)-3-(2-nitrophenyl)urea
  参考文献：
  名称：

  Bis amide-aromatic-ureas—highly effective hydro- and organogelator systems

  摘要：

  A series of hydro- and organo-supergelators have been synthesised via coupling of simple bis aromatic-ureas via alkyl amide linkages. These bis amide-aromatic-ureas exhibited reduced critical gelator concentrations, improved gelator stability, mechanical and dye removal properties for potential use in water purification, in comparison to related bis aromatic-ureas. Systematic structure studies via variation of the bis amide-aromatic-urea linker length as well as functionalization of the terminal aromatic moieties have enabled control over the gel properties. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.09.017

文献信息

• SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT
  申请人：Brouillette Wayne J.

  公开号：US20110275635A1

  公开（公告）日：2011-11-10

  Small molecule inhibitors of bacterial nicotinamide adenine dinucleotide synthetase (NADs), bacterial nicotinic acid mononucleotide adenylyltransferase (NaMNAT), and human nicotinamide mononucleotide adenylyltransferase (NMNAT) are provided, as well as methods of making and using the inhibitors.

  提供了细菌烟酰胺腺嘌呤二核苷酸合成酶（NADs）、细菌烟酸单核苷酸腺苷酰转移酶（NaMNAT）和人类烟酰胺单核苷酸腺苷酰转移酶（NMNAT）的小分子抑制剂，以及制备和使用这些抑制剂的方法。
• [EN] SMALL MOLECULE INHIBITORS OF NADS, NAMNAT, AND NMNAT<br/>[FR] PETITES MOLECULES INHIBITRICES DE NADS, NAMNAT ET NMNAT
  申请人：UAB RESEARCH FOUNDATION

  公开号：WO2010123591A2

  公开（公告）日：2010-10-28

  Small molecule inhibitors of bacterial nicotinamide adenine dinucleotide synthetase (NADs), bacterial nicotinic acid mononucleotide adenylyltransferase (NaMNAT), and human nicotinamide mononucleotide adenylyltransferase (NMNAT) are provided, as well as methods of making and using the inhibitors.
• Bis amide-aromatic-ureas—highly effective hydro- and organogelator systems
  作者：B.C. Baker、A.L. Acton、G.C. Stevens、W. Hayes

  DOI：10.1016/j.tet.2014.09.017

  日期：2014.11

  A series of hydro- and organo-supergelators have been synthesised via coupling of simple bis aromatic-ureas via alkyl amide linkages. These bis amide-aromatic-ureas exhibited reduced critical gelator concentrations, improved gelator stability, mechanical and dye removal properties for potential use in water purification, in comparison to related bis aromatic-ureas. Systematic structure studies via variation of the bis amide-aromatic-urea linker length as well as functionalization of the terminal aromatic moieties have enabled control over the gel properties. (C) 2014 Elsevier Ltd. All rights reserved.