6-deoxy-1-amino-D-mannitol

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 6-deoxy-1-amino-D-mannitol
• 英文别名: (2R,3R,4R,5R)-1-aminohexane-2,3,4,5-tetrol
• 化学式: C₆H₁₅NO₄
• 分子量: 165.189
• InChiKey: PKKXIMIVMVHGSA-KVTDHHQDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  107
• 氢给体数：
  5
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-deoxy-1-amino-D-mannitol 在 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 5.0h， 生成 6-deoxy-D-mannitol 1-anthramide-2,3,4,5-tetra-p-methoxycinnamate
  参考文献：
  名称：

  Assignment of relative and absolute configuration of acyclic polyols and aminopolyols by circular dichroism - trends follow fischer's sugar family tree

  摘要：

  Reference CD curves (measured in methylcyclohexane) of a homologous series of 1,2-polyols up to pentols derivatized as anthroates at 1-OH and p-methoxycinnamates at the remaining hydroxyl groups show a systematic trend that greatly simplifies assignments of relative and absolute configurations. The same trend also holds for the corresponding 1-aminopolyols, but not for 2-aminopolyols.

  DOI：

  10.1016/0040-4020(93)80020-t
• 作为产物：
  描述：

  5-氯-2-氟三氟甲苯 在 sodium cyanoborohydride 、 氯化铵 作用下， 以 甲醇 为溶剂， 反应 2.0h， 以40%的产率得到6-deoxy-1-amino-D-mannitol
  参考文献：
  名称：

  Assignment of relative and absolute configuration of acyclic polyols and aminopolyols by circular dichroism - trends follow fischer's sugar family tree

  摘要：

  Reference CD curves (measured in methylcyclohexane) of a homologous series of 1,2-polyols up to pentols derivatized as anthroates at 1-OH and p-methoxycinnamates at the remaining hydroxyl groups show a systematic trend that greatly simplifies assignments of relative and absolute configurations. The same trend also holds for the corresponding 1-aminopolyols, but not for 2-aminopolyols.

  DOI：

  10.1016/0040-4020(93)80020-t

文献信息

• Process for the removal of basic materials from plant products
  申请人：Philip Morris Products Inc.

  公开号：EP0280817A2

  公开（公告）日：1988-09-07

  A process is provided for the selective removal of basic materials from plant products, in particular, for removing nicotine from tobacco without materially affecting the content of the other components of the tobacco. Tobacco is. traversed with a solvent in the supercritical state or in the liquid state wherein nicotine and the other components dissolve in the solvent. The solvent is then passed through an acid-containing trap where the solvent is essentially freed of nicotine. The solvent, depleted of nicotine and enriched in the other components, is then recycled to the tobacco to reextract nicotine. In addition, the tobacco may be pretreated with a chemical base which does not substantially react withe the tobacco components under ambient conditions but rather is activated under the conditions of the extraction process. Pretreatment of the tobacco with a chemical base neutralizes nicotine salts and permits the extraction process to be carried out under milder conditions.

  本发明提供了一种从植物产品中选择性去除基本物质的工艺，特别是在不对烟草中其他成分的含量产生实质性影响的情况下去除烟草中的尼古丁。烟草在超临界状态或液态下与溶剂混合，尼古丁和其他成分溶解在溶剂中。然后，溶剂通过一个含酸的捕集器，溶剂中的尼古丁基本上被释放出来。然后，去掉尼古丁、富含其他成分的溶剂被回收到烟草中，重新提取尼古丁。此外，还可以用一种化学碱对烟草进行预处理，这种化学碱在环境条件下不会与烟草成分发生实质性反应，而是在萃取工艺条件下被激活。用化学碱对烟草进行预处理，可以中和烟碱盐，使萃取过程在较温和的条件下进行。
• US4638816A
  申请人：——

  公开号：US4638816A

  公开（公告）日：1987-01-27
• US5018540A
  申请人：——

  公开号：US5018540A

  公开（公告）日：1991-05-28
• Assignment of relative and absolute configuration of acyclic polyols and aminopolyols by circular dichroism - trends follow fischer's sugar family tree
  作者：Peng Zhou、Nikolina Berova、William T. Wiesler、Koji Nakanishi

  DOI：10.1016/0040-4020(93)80020-t

  日期：——

  Reference CD curves (measured in methylcyclohexane) of a homologous series of 1,2-polyols up to pentols derivatized as anthroates at 1-OH and p-methoxycinnamates at the remaining hydroxyl groups show a systematic trend that greatly simplifies assignments of relative and absolute configurations. The same trend also holds for the corresponding 1-aminopolyols, but not for 2-aminopolyols.