cinnamyl 2-(2,3-dimethylphenylamino)benzoate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: cinnamyl 2-(2,3-dimethylphenylamino)benzoate
• 英文别名: [(E)-3-phenylprop-2-enyl] 2-(2,3-dimethylanilino)benzoate
• 化学式: C₂₄H₂₃NO₂
• 分子量: 357.452
• InChiKey: OIMWPABFDPKTSR-UKTHLTGXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  扑湿痛 、 3-苯基丙-2-烯-1-醇 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 反应 4.0h， 以91%的产率得到cinnamyl 2-(2,3-dimethylphenylamino)benzoate
  参考文献：
  名称：

  Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity

  摘要：

  Novel esters of non steroidal anti-inflammatory drugs, a-lipoic acid and indol-3-acetic acid with cinnamyl alcohol were synthesised by a straightforward method and at high yields (60-98%). They reduced acute inflammation more than the parent acids and are potent inhibitors of soybean lipoxygenase. Selected structures decreased plasma lipidemic indices in Triton-induced hyperlipidemia to rats. Therefore, the synthesised compounds may add to the current knowledge about agents acting against various inflammatory disorders. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.10.036