(+)-2-[(inden-7-yloxy)methyl]morpholine benzene sulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+)-2-[(inden-7-yloxy)methyl]morpholine benzene sulfonate
• 英文别名: benzenesulfonic acid;2-(3H-inden-4-yloxymethyl)morpholine
• 化学式: C₆H₆O₃S*C₁₄H₁₇NO₂
• 分子量: 389.472
• InChiKey: HLSBLOLRAXOIFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.56
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  93.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (+)-2-[(inden-7-yloxy)methyl]morpholine (-)-(2R,3R)-di-O-benzoyl tartrate 、 苯磺酸 在 碳酸氢钠 作用下， 以 水 、 乙酸乙酯 、 乙醇 为溶剂， 生成 (+)-2-[(inden-7-yloxy)methyl]morpholine benzene sulfonate
  参考文献：
  名称：

  EP2329824

  摘要：

  公开号：

文献信息

• NOVEL SALT OF MORPHOLINE DERIVATIVE
  申请人：Kikuchi Kazumi

  公开号：US20110166348A1

  公开（公告）日：2011-07-07

  Provided are an acid addition salt of (+)-2-[(inden-7-yloxy)methyl]morpholine (compound A) and a novel crystal thereof, which are for use as a medicament or a drug substance, and which has high storage stability, particularly high stability against humidity and light. An acid addition salt of the compound A with an acid selected from benzenesulfonic acid and hydrobromic acid is a compound which is isolated in the form of a crystal, is a solid at room temperature, exhibits no hygroscopicity at such a level that causes a problem for use as a medicament or a drug substance, has stability against humidity and light, and is therefore extremely useful as a medicament or a drug substance.

  提供一种(+)-2-[(茚七氧基)甲基]吗啡啶（化合物A）的酸加成盐及其新型晶体，用作药物或药物物质，具有高储存稳定性，尤其是高湿度和光稳定性。化合物A与苯磺酸和氢溴酸等酸的酸加成盐是一种以晶体形式分离出来的化合物，它在室温下是固体，不具有吸湿性，可用作药物或药物物质，对湿度和光稳定性具有稳定性，因此非常有用。
• NOVEL PHARMACEUTICAL COMPOSITION FOR TREATMENT OF NOCICEPTIVE PAIN
  申请人：Astellas Pharma Inc.

  公开号：EP2329824A1

  公开（公告）日：2011-06-08

  Provided is a novel potent pharmaceutical composition for treating nociceptive pain. The present invention relates to a pharmaceutical composition for treating nociceptive pain, containing a morpholine derivative or a pharmaceutically acceptable salt thereof, as an active ingredient. The present invention is useful in providing an excellent pharmaceutical composition for treating nociceptive pain. In addition, the present invention is particularly useful in providing a pharmaceutical composition for treating pain accompanying a disease selected from the group consisting of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, spondylosis deformans, gouty arthritis, juvenile arthritis, scapulohumeral periarthritis, and cervical syndrome, lumbago, lumbago accompanying spondylosis deformans, menalgia, pain and tumentia after inflammation, operation or injury, pain after odontectomy, and cancer pain. In addition, the present invention is particularly useful for alleviating pain in a damaged cartilage region, and is particularly useful for osteoarthritis in which NSAIDs are not effective.

  本发明提供了一种用于治疗痛觉疼痛的新型强效药物组合物。 本发明涉及一种治疗痛觉疼痛的药物组合物，其中含有吗啉衍生物或其药学上可接受的盐作为活性成分。本发明有助于提供一种治疗痛觉疼痛的优良药物组合物。此外，本发明特别适用于提供一种药物组合物，用于治疗选自类风湿性关节炎、类风湿性脊柱炎、骨关节炎、脊柱变形症、痛风性关节炎、骨关节炎、脊柱变形症、骨关节炎、脊柱变形症等疾病的伴随疼痛、痛风性关节炎、幼年关节炎、肩胛肱骨周围关节炎和颈椎综合征、腰痛、腰痛伴有脊柱变形症、脑痛、炎症、手术或损伤后疼痛和肿块、耳鼻喉切除术后疼痛和癌痛。此外，本发明特别适用于缓解软骨受损区域的疼痛，尤其适用于非甾体抗炎药无效的骨关节炎。
• NOVEL PHARMACEUTICAL COMPOSITION FOR TREATING NOCICEPTIVE PAIN
  申请人：Takeshita Nobuaki

  公开号：US20110152268A1

  公开（公告）日：2011-06-23

  The present invention relates to a pharmaceutical composition for treating nociceptive pain, containing a morpholine derivative or a pharmaceutically acceptable salt thereof, as an active ingredient. The present invention is useful in providing an excellent pharmaceutical composition for treating nociceptive pain. In addition, the present invention is particularly useful in providing a pharmaceutical composition for treating pain accompanying a disease selected from the group consisting of rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, spondylosis deformans, gouty arthritis, juvenile arthritis, scapulohumeral periarthritis, and cervical syndrome, lumbago, lumbago accompanying spondylosis deformans, menalgia, pain and tumentia after inflammation, operation or injury, pain after odontectomy, and cancer pain. In addition, the present invention is particularly useful for alleviating pain in a damaged cartilage region, and is particularly useful for osteoarthritis in which NSAIDs are not effective.
• EP2329824
  申请人：——

  公开号：——

  公开（公告）日：——