5-TMR-B

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-TMR-B
• 英文别名: [9-[2-Carboxy-4-[(4-carboxyphenyl)methylcarbamoyl]phenyl]-6-(dimethylamino)xanthen-3-ylidene]-dimethylazanium
• 化学式: C₃₃H₃₀N₃O₆
• 分子量: 564.618
• InChiKey: OJZWPNHSFMZSEN-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  42
• 可旋转键数：
  7
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  119
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-TMR-B 、 N,N'-二琥珀酰亚胺基碳酸酯 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.08h， 以8%的产率得到5-TMR-B-NHS
  参考文献：
  名称：

  Method for detecting oligonucleotides using energy transfer dyes with long stoke shift

  摘要：

  提供了一种新的连接剂，用于将给体染料与受体染料连接在能量转移荧光染料中。这些连接剂促进了给体染料和受体染料之间的能量高效转移。其中一种连接剂用于将给体染料与受体染料连接在能量转移荧光染料中，具有一般结构R21Z1C（O）R22R26，其中R21是附加在给体染料上的C1-5烷基，C（O）是一个羰基，Z1是NH、硫或氧，R22是一个取代基，包括烯烃、二烯、炔烃、至少有一个不饱和键的五元和六元环或附加在羰基碳上的融合环结构，而R28包括一个功能基团，将连接剂连接到受体染料上。

  公开号：

  US06335440B1
• 作为产物：
  描述：

  4-氨甲基苯甲酸 、 5-carboxytetramethylrhodamine succinimidyl ester 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 生成 5-TMR-B
  参考文献：
  名称：

  Method for detecting oligonucleotides using energy transfer dyes with long stoke shift

  摘要：

  提供了一种新的连接剂，用于将给体染料与受体染料连接在能量转移荧光染料中。这些连接剂促进了给体染料和受体染料之间的能量高效转移。其中一种连接剂用于将给体染料与受体染料连接在能量转移荧光染料中，具有一般结构R21Z1C（O）R22R26，其中R21是附加在给体染料上的C1-5烷基，C（O）是一个羰基，Z1是NH、硫或氧，R22是一个取代基，包括烯烃、二烯、炔烃、至少有一个不饱和键的五元和六元环或附加在羰基碳上的融合环结构，而R28包括一个功能基团，将连接剂连接到受体染料上。

  公开号：

  US06335440B1

文献信息

• METHODS OF ANALYZING POLYNUCLEOTIDES EMPLOYING ENERGY TRANSFER DYES
  申请人：Lee G. Linda

  公开号：US20070154925A1

  公开（公告）日：2007-07-05

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• ENERGY TRANSFER DYES WITH ENHANCED FLUORESCENCE
  申请人：Lee G. Linda

  公开号：US20070154927A1

  公开（公告）日：2007-07-05

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• OLIGONUCLEOTIDES AND ANALOGS LABELED WITH ENERGY TRANSFER DYES
  申请人：Lee G. Linda

  公开号：US20070161027A1

  公开（公告）日：2007-07-12

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• REGENTS LABELED WITH ENERGY TRANSFER DYES
  申请人：Lee G. Linda

  公开号：US20070161026A1

  公开（公告）日：2007-07-12

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.
• METHODS OF LABELING NUCLEIC ACIDS WITH ENERGY TRANSFER DYES
  申请人：Lee G. Linda

  公开号：US20070212709A1

  公开（公告）日：2007-09-13

  Novel linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye are provided. These linkers faciliate the efficient transfer of energy between a donor and acceptor dye in an energy transfer dye. One of these linkers for linking a donor dye to an acceptor dye in an energy transfer fluorescent dye has the general structure R 21 Z 1 C(O)R 22 R 28 where R 21 is a C 1-5 alkyl attached to the donor dye, C(O) is a carbonyl group, Z 1 is either NH, sulfur or oxygen, R 22 is a substituent which includes an alkene, diene, alkyne, a five and six membered ring having at least one unsaturated bond or a fused ring structure which is attached to the carbonyl carbon, and R 28 includes a functional group which attaches the linker to the acceptor dye.