10-methyl-2,4-di-p-tolyl-2,4-diazaspiro[5.5]undecan-7-one

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 10-methyl-2,4-di-p-tolyl-2,4-diazaspiro[5.5]undecan-7-one
• 英文别名: 8-Methyl-2,4-bis(4-methylphenyl)-2,4-diazaspiro[5.5]undecan-11-one
• 化学式: C₂₄H₃₀N₂O
• 分子量: 362.515
• InChiKey: JZLGWWSFKBEAAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 乙烷,三氯氟- 、 4-甲基环己酮 在 (H₁₄[NaP₅W₃₀O₁₁₀])/SiO₂ 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 30.0h， 以73%的产率得到10-methyl-2,4-di-p-tolyl-2,4-diazaspiro[5.5]undecan-7-one
  参考文献：
  名称：

  支持的Preyssler纳米颗粒在1,3-二芳基-5-螺六氢嘧啶的合成中

  摘要：

  二氧化硅支撑的Preyssler纳米颗粒（H 14 [NaP 5 W 30 O 110 ]）/ SiO 2被用作一种新型可循环使用的催化剂，可通过苯胺的一锅缩合制备1,3-二芳基-5-螺六氢嘧啶，甲醛和环己酮。

  DOI：

  10.1002/jccs.200900035

文献信息

• Supported Preyssler Nanoparticles in Synthesis of 1,3-Diaryl-5-Spirohexahydropyrimidines
  作者：Majid M. Heravi、Samaheh Sadjadi、Sodeh Sadjadi、Hossein A. Oskooie、Rahim Hekmat Shoar、Fatemeh F. Bamoharram

  DOI：10.1002/jccs.200900035

  日期：2009.4

  Silica‐supported Preyssler nanoparticles (H14[NaP5W30O110])/SiO2 are used as a new and recyclable catalyst for the preparation of 1,3‐diaryl‐5‐spirohexahydropyrimidines via a one‐pot condensation of anilines, formaldehyde, and cyclohexanone.

  二氧化硅支撑的Preyssler纳米颗粒（H 14 [NaP 5 W 30 O 110 ]）/ SiO 2被用作一种新型可循环使用的催化剂，可通过苯胺的一锅缩合制备1,3-二芳基-5-螺六氢嘧啶，甲醛和环己酮。
• Indium triflate catalyzed one-pot multicomponent synthesis of spiro-hexahydropyrimidines explained by multiple covalent bond formation
  作者：Anshu Dandia、Anuj K. Jain、Sonam Sharma

  DOI：10.1016/j.tetlet.2012.07.079

  日期：2012.9

  A mild, efficient, and expeditious method has been developed for the synthesis of spiro-hexahydropyrimidine derivatives via a three-component, one-pot cyclocondensation reaction of aromatic amines, formaldehyde, and cyclic ketones in 4-6 h using In(OTf)(3) as Lewis acid catalyst for the first time. The reaction involving creation of six new covalent bonds was efficiently promoted by 10 mol % In(OTf)(3) and the catalyst could be recovered easily after the reaction and reused without any loss of its catalytic activity. The advantageous features of this methodology are high atom-economy, operational simplicity, shorter reaction time, and easy handling. (c) 2012 Elsevier Ltd. All rights reserved.
• New Light on an Old Story:  Facile and Efficient Synthesis of 1,3-Diaryl-5-spirohexahydro- pyrimidines via a Six-Molecule, Three-Component Mannich-Type Reaction
  作者：Hai-Long Wei、Ze-Yi Yan、Yan-Ning Niu、Gao-Qiang Li、Yong-Min Liang

  DOI：10.1021/jo7016235

  日期：2007.10.1

  A facile and efficient synthesis of I,3-diaryl-5-spirohexahy-dropyrimidines via a one-pot condensation of anilines, formaldehyde, and cyclohexanones is reported. In this one-pot, three-component reaction, six molecules of reactants are involved and six new covalent bonds are generated. Bicyclic products are obtained from the starting materials in one pot using readily available starting materials and catalysts.
• CuFe2O4 nanoparticles as a highly efficient and magnetically recoverable catalyst for the synthesis of medicinally privileged spiropyrimidine scaffolds
  作者：Anshu Dandia、Anuj K. Jain、Sonam Sharma

  DOI：10.1039/c2ra22477a

  日期：——

  A highly efficient and green protocol for the synthesis of medicinally important fluorinated spiropyrimidine derivatives involving creation of six new covalent bonds has been developed using a magnetically separable and reusable heterogeneous copper ferrite nanocatalyst under mild reaction conditions. The synthesis of inverse spinel copper ferrite magnetic nanoparticles with average size of 38 nm has been achieved using combined sonochemical and co-precipitation techniques in aqueous medium from readily available inexpensive starting materials without any surfactant or capping agent. The particle size was determined by transmission electron microscopy (TEM), scanning electron microscopy (SEM) and X-ray diffraction (XRD) analysis. The magnetic nature of catalyst facilitates its easy removal from the reaction medium and can be reused five times without any significant loss of its catalytic activity. Negligible leaching of Cu and Fe in consecutive cycles makes the catalyst economical and environmentally benign. The structure of final products was established by single crystal X-ray analysis and spectroscopic techniques.

  开发了一种高效绿色的合成重要药用氟化螺嘧啶衍生物的协议，该协议涉及在温和反应条件下使用磁性可分离和可重复使用的异质铜铁氧体纳米催化剂创造六个新的共价键。通过在水性介质中结合声化学和共沉淀技术，从易于获取的廉价起始材料中，无需任何表面活性剂或配体，实现了反尖晶石铜铁氧体磁性纳米粒子的合成，平均粒径为38 nm。粒径通过透射电子显微镜（TEM）、扫描电子显微镜（SEM）和X射线衍射（XRD）分析确定。催化剂的磁性质使其易于从反应介质中去除，并且可以重复使用五次而不显著损失其催化活性。在连续循环中Cu和Fe的渗出可以忽略不计，使得催化剂经济且环境友好。最终产品的结构通过单晶X射线分析和光谱技术确定。