二(羟基苯基甲基)-次磷酸 | 90-09-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 二(羟基苯基甲基)-次磷酸
• 英文名称: bis-(α-hydroxyphenylmethyl)phosphinic acid
• 英文别名: bis(α-hydroxyphenylmethyl)phosphinic acid；bis(α-hydroxybenzyl)phosphinic acid；bis(hydroxy(phenyl)methyl)phosphinic acid；bis-α-hydroxybenzylphosphonic acid；bis[hydroxy(phenyl)methyl]phosphinic acid；bis-(α-hydroxy-benzyl)-phosphinic acid；Bis(hydroxyphenylmethyl)phosphinic acid
• CAS: 90-09-5；112162-61-5；112162-62-6
• 化学式: C₁₄H₁₅O₄P
• 分子量: 278.244
• InChiKey: YMIKTLVFXBBWKP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  77.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  二(羟基苯基甲基)-次磷酸 在 磷化氢 、 氢碘酸 作用下， 生成 dibenzylphosphinic acid
  参考文献：
  名称：

  Ettel,V.; Horak,J., Collection of Czechoslovak Chemical Communications, 1961, vol. 26, p. 1949 - 1957

  摘要：

  DOI：
• 作为产物：
  描述：

  trimethylsilyl bis(phenyl((trimethylsilyl)oxy)methyl)phosphinate 在 乙醇 作用下， 反应 0.17h， 以95%的产率得到二(羟基苯基甲基)-次磷酸
  参考文献：
  名称：

  A New Method for the Preparation of Bis(1-hydroxyalkyl)-phosphinic Acids

  摘要：

  双（1-羟基烷基）膦酸6可通过在氯三甲基硅烷和三乙胺存在下，将双（三甲基硅氧基）膦1添加到醛或酮2中，然后对所得的三甲基硅烷基双（1-三甲基硅氧烷基烷基）-膦酸酯5进行乙醇化，从而方便地获得。

  DOI：

  10.1055/s-1987-28001

文献信息

• PHOTO ACTIVE AGENTS
  申请人：Hewlett-Packard Development Company, L.P.

  公开号：US20190276482A1

  公开（公告）日：2019-09-12

  The present disclosure is drawn to a photo active agent which includes a bisacylphosphinic compound in the form of an acid or salt having Structure I: where A and A′ are independently aryl or from C2 to C8 lower alkyl; M is H, a monovalent cation, a divalent cation, or mixture thereof; n is 1 or 2; and q is 1 or 2. The photo active agent can be present in a composition that includes from 0.001 wt % to 5 wt % of a dialcohol phosphinic acid precursor or dialcohol phosphinic salt of the bisacylphosphinic compound of Structure I.

  本公开涉及一种光活性剂，其包括一种以酸或盐的形式存在的双酰基膦化合物，具有结构I：其中A和A′分别是芳基或C2至C8低碳链烷基；M是H、一价阳离子、二价阳离子或它们的混合物；n为1或2；q为1或2。该光活性剂可以存在于包含结构I双酰基膦化合物的二元醇膦酸前体或二元醇膦盐，其含量在0.001重量%至5重量%之间的组合物中。
• [EN] NOVEL PHOTO-INITIATORS AND THEIR APPLICATION<br/>[FR] NOUVEAUX PHOTO-INITIATEURS ET LEUR UTILISATION
  申请人：ETH ZUERICH

  公开号：WO2019175112A1

  公开（公告）日：2019-09-19

  The present invention relates to novel bisacylphosphinic acids, salts and derivatives thereof as well as their use as photo-initiators with superior water solubility and photo-activity. The invention further encompasses versatile processes for the preparation of the aforementioned compounds.

  本发明涉及新型双酰基膦酸、其盐和衍生物，以及它们作为具有优越水溶性和光活性的光引发剂的用途。本发明还涵盖了用于制备上述化合物的多功能过程。
• Synthesis of new functionalized mono- and bisorganophosphorus acids and their derivatives with unsaturated and aromatic fragments
  作者：Andrey A. Prishchenko、Mikhail V. Livantsov、Olga P. Novikova、Ludmila I. Livantsova、Valery S. Petrosyan

  DOI：10.1002/hc.20749

  日期：——

  Convenient procedures for the synthesis of functionalized mono- and bisorganophosphorus acids and their derivatives with unsaturated and aromatic fragments, starting from the available derivatives of trivalent phosphorus acids, unsaturated and aromatic aldehydes, and carboxylic acid chlorides, are proposed, and some properties of the new unsaturated organophosphorus compounds are presented. © 2011

  提出了从三价磷酸、不饱和醛和芳香醛以及羧酸氯化物的可用衍生物开始合成功能化单和双有机磷酸及其衍生物的简便方法，以及这些新化合物的一些性质介绍了不饱和有机磷化合物。© 2011 Wiley Periodicals, Inc. 杂原子化学 23:32–40, 2012; 在 wileyonlinelibrary.com 上在线查看这篇文章。DOI 10.1002/hc.20749
• Synthesis of a New Class of Phosphinic Acids: Synthesis of Novel Four-Membered Cyclic Oxaphosphetanes by Intramolecular Mitsunobu Reaction of Bis(α-hydroxyalkyl)phosphinic Acids
  作者：Babak Kaboudin、Hamideh Haghighat、Tsutomu Yokomatsu

  DOI：10.1055/s-0030-1260170

  日期：2011.10

  novel class of phosphinic acid derivatives, four-membered cyclic oxaphosphetanes, was synthesized by the reaction of bis(hydroxymethyl)phosphinic acids with a mixture of triphenylphosphine and diisopropyl azodicarboxylate in toluene-dichloromethane at room temperature via an intramolecular Mitsunobu reaction. bis(α-hydroxyalkyl)phosphinic acids - oxaphosphetane - cyclic phosphinic acids - Mitsunobu reaction

  通过双（羟甲基）次膦酸与三苯基膦和偶氮二羧酸二异丙酯的混合物在室温下通过分子内的Mitsunobu反应，合成了一类新型的次膦酸衍生物四元环氧杂膦酸酯。 双（α-羟烷基）次膦酸-氧杂膦烷-环状次膦酸-Mitsunobu反应
• Phosphorylating Power of Red Phosphorus towards Aldehydes in Basic and in Acidic Media
  作者：Dominique Albouy、Guita Etemad-Moghadam、Max Koenig

  DOI：10.1002/(sici)1099-0690(199904)1999:4<861::aid-ejoc861>3.0.co;2-j

  日期：1999.4

  investigated under basic and acidic media. It was demonstrated that the real phosphorylating agent involved in the reaction was phosphane (PH3) in basic media, and hypophosphorous acid (H3PO2) in acidic media. A convenient one-pot synthesis of (α-hydroxyalkyl)phosphinic acids from red phosphorus and aldehydes in basic media was realized under sonication. The same reaction under acidic media in the presence

  在碱性和酸性介质下研究了红磷对醛的反应性。结果表明，参与反应的真正磷酸化剂是碱性介质中的磷烷（PH3）和酸性介质中的次磷酸（H3PO2）。在超声处理下，从红磷和醛在碱性介质中方便地一锅合成（α-羟烷基）次膦酸。在氢碘酸存在下在酸性介质下的相同反应产生相应的膦酸。(α-羟烷基)次膦酸在催化量的盐酸存在下，在次磷酸和醛的超声处理下很容易制备。