(S)-2-(Tetrahydrofuran-2-yl)ethan-1-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: (S)-2-(Tetrahydrofuran-2-yl)ethan-1-amine
• 英文别名: 2-[(2S)-oxolan-2-yl]ethanamine
• 化学式: C₆H₁₃NO
• 分子量: 115.17
• InChiKey: ZCOIVJPCZLPQPT-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  35.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• NOVEL ANNELATED PHENOXYACETAMIDES
  申请人：Boehringer Ingelheim International GmbH

  公开号：US20170050992A1

  公开（公告）日：2017-02-23

  The present invention relates to compounds of formula (I) wherein R 1 , R 2 , R 3 , and Z − have one of the meanings as indicated in the specification or a pharmaceutically acceptable salt thereof, to the use of compounds of formula (I) as a medicament, to pharmaceutical compositions comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).

  本发明涉及式(I)的化合物，其中R1、R2、R3和Z-具有规范中指示的含义之一，或其药学上可接受的盐，以及将式(I)的化合物用作药物的用途，包括至少一个式(I)化合物的药物组成物，以及含有一个或多个式(I)化合物的药物组合物。
• Annelated phenoxyacetamides
  申请人：Boehringer Ingelheim International GmbH

  公开号：US10221202B2

  公开（公告）日：2019-03-05

  The present invention relates to compounds of formula (I) wherein R1, R2, R3, and Z− have one of the meanings as indicated in the specification or a pharmaceutically acceptable salt thereof, to the use of compounds of formula (I) as a medicament, to pharmaceutical compositions comprising at least one compound of formula (I), as well as to medicament combinations containing one or more compounds of formula (I).

  本发明涉及式 (I) 的化合物 其中 R1、R2、R3 和 Z- 具有说明书中所述的含义之一或其药学上可接受的盐；涉及式 (I) 化合物作为药物的用途；涉及包含至少一种式 (I) 化合物的药物组合物；以及涉及包含一种或多种式 (I) 化合物的药物组合物。
• [EN] SYNTHESIS OF DIACIDS, DIALDEHYDES, OR DIAMINES FROM THF-DIOLS<br/>[FR] SYNTHÈSE DE DIACIDES, DE DIALDÉHYDES OU DE DIAMINES À PARTIR DE TÉTRAHYDROFURANE-DIOLS
  申请人：ARCHER DANIELS MIDLAND CO

  公开号：WO2015057365A2

  公开（公告）日：2015-04-23

  A simple and elegant chemical process for the synthesis of oxygenated products, such as acids and aldehydes, or other derivative products, such as amines and nitriles, of cyclic bifunctional molecules made from renewable, bio-based sources such as HMF and/or its reduction product, 2,5-bis(hydroxymethyl)-tetrahydrofuran (bHMTHF) is described. In general, the process involves: a) generating a tetrahydrofuran-2,5-diyl-bis(methylene)-bis(sulfonate) from bHMTHFs using a sulfonate; b) displacing nucleophilically at least a sulfonate leaving group from the tetrahydrofuran-2,5-diyl-bis(methylene)-bis(sulfonate) to form a THF-dinitrile; and either c) oxidizing the THF-dinitrile with an acid having a pKa of ≤ 0 to generate a di-acid, or d) reducing partially the THF-dinitrile to generate a di-aldehyde, or e) reducing fully the THF-dinitrile to generate a di-amine.