申请人:Yamanouchi Pharmaceutical Co., Ltd.
公开号:US04252819A1
公开(公告)日:1981-02-24
Novel heterocyclic compounds shown by the formula ##STR1## wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); Z represents a sulfur atom or oxygen atom; X represents an oxygen atom or the unsubstituted or substituted imino group shown by N--R.sub.1 (wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a cyano group, an unsubstituted or alkyl substituted carbamoyl group, an unsubstituted or lower alkyl substituted thiocarbamoyl group, or a lower alkanoylamino group); Y represents a hydrogen atom, a lower alkyl group which may have substituent(s), a cycloalkyl group of 3-6 carbon atoms, a lower alkenyl group, a lower alkynyl group, an aryl group which may have substituent(s), an aralkyl group which may have substituent(s), a hydroxyl group, a cyano group, a carbamoyl group, an amidino group, an alkanoyl group which may have been substituted by halogen atom(s), an alkanoylamino group, an arylcarbonylamino group, an alkylamino group, an arylamino group, an arylsulfamoyl group, a lower alkoxycarbamoyl group, or an oxamoylamino group; and m and n represent an integer of 1-3; when X is N-R.sub.1, said X and Y may combine with each other to form a 5-membered or 6-membered heterocyclic ring containing 2-3 nitrogen atoms which may have substituent(s), and the pharmaceutically acceptable acid addition salts thereof. The compounds of this invention are useful as gastric acid secretion inhibitors.
本发明涉及一种新型杂环化合物,其化学式如下:##STR1##其中,Het代表一个5-或6-成员杂环基团,可以具有取代基;Z代表硫原子或氧原子;X代表氧原子或N-R.sub.1所示的未取代或取代亚胺基团(其中R.sub.1为氢原子、较低烷基基团、氰基、未取代或烷基取代的氨基甲酰基团、未取代或较低烷基取代的硫代氨基甲酰基团或较低烷酰胺基团);Y代表氢原子、可能具有取代基的较低烷基基团、3-6个碳原子的环烷基基团、较低烯基基团、较低炔基基团、可能具有取代基的芳基团、可能具有取代基的芳基烷基团、羟基、氰基、氨基甲酰基团、胺基甲酰基团、可能已被卤素原子取代的酰基基团、酰胺基甲酰基团、芳基甲酰胺基团、烷基胺基团、芳基胺基团、芳基磺酰胺基团、较低烷氧基甲酰基团或氧代氨基甲酰基团;m和n代表1-3的整数;当X为N-R.sub.1时,所述的X和Y可以结合在一起形成一个含有2-3个氮原子的5-或6-成员杂环环,该环可能具有取代基,并且其在药学上可接受的酸盐。本发明的化合物可用作胃酸分泌抑制剂。