N₁,N₃-diallyl-5-fluorouracil

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: N₁,N₃-diallyl-5-fluorouracil
• 英文别名: 5-Fluoro-1,3-bis(prop-2-EN-1-YL)-1,2,3,4-tetrahydropyrimidine-2,4-dione；5-fluoro-1,3-bis(prop-2-enyl)pyrimidine-2,4-dione
• 化学式: C₁₀H₁₁FN₂O₂
• mdl: MFCD01572429
• 分子量: 210.208
• InChiKey: HUHNGVYFDANKTL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  40.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  5-氟脲嘧啶 、 3-溴丙烯 生成 N₁,N₃-diallyl-5-fluorouracil
  参考文献：
  名称：

  AXVERDIEVA, R. YA.;MAMEDOV, EH. SH.;BABAXANOV, R. A., GETEROG. KATAL. V XIMII GETEROTSIKL. SOED. 4 BCEC. SIMP., RIGA, 23-25 CEH+

  摘要：

  DOI：

文献信息

• N-Alkylated Derivatives of 5-Fluorouracil
  作者：Nitya G. Kundu、Scott A. Schmitz

  DOI：10.1002/jps.2600710825

  日期：1982.8

  Some N-alkyl derivatives of 5-fluorouracil were designed to act as latent depot forms of 5-fluorouracil. A general and efficient method for the syntheses of the alkylated derivatives is described. As expected, the alkylated derivatives of 5-fluorouracil did not show any cytotoxicity in cell culture systems even up to 10(-4) M concentration. The synthesis of 1,3-dimethyl-5-fluoro-5,6-dihydrouracil is

  设计一些5-氟尿嘧啶的N-烷基衍生物，以充当5-氟尿嘧啶的潜在贮库形式。描述了用于合成烷基化衍生物的通用且有效的方法。正如预期的那样，即使浓度高达10（-4）M，5-氟尿嘧啶的烷基化衍生物在细胞培养系统中也没有表现出任何细胞毒性。还描述了1，3-二甲基-5-氟-5，6-二氢尿嘧啶的合成。
• Efficient synthesis of various acycloalkenyl derivatives of pyrimidine using cross-metathesis and Pd(0) methodologies
  作者：Franck Amblard、Steven P. Nolan、Raymond F. Schinazi、Luigi A. Agrofoglio

  DOI：10.1016/j.tet.2004.11.019

  日期：2005.1

  Novel acyclonucleosides (9a-d, 10a-d, 18a,b and 19a,b) have been prepared using Pd(0) and cross-metathesis methodologies. The allylic N-alkylation under Tsuji-Trost conditions was used to introduce the nucleobase, while the Suzuki-Miyaura reaction afforded C-5 substituted uracil analogues. The cross-metathesis performed with a ruthenium catalyst was used to provide new acycloalkenyl nucleosides. The antiviral activities of all final compounds have been evaluated. (C) 2004 Elsevier Ltd. All rights reserved.
• AXVERDIEVA, R. YA.;MAMEDOV, EH. SH.;BABAXANOV, R. A., GETEROG. KATAL. V XIMII GETEROTSIKL. SOED. 4 BCEC. SIMP., RIGA, 23-25 CEH+
  作者：AXVERDIEVA, R. YA.、MAMEDOV, EH. SH.、BABAXANOV, R. A.

  DOI：——

  日期：——