N-(2,4,5-trichlorophenyl)pyridine-3-carboxamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2,4,5-trichlorophenyl)pyridine-3-carboxamide
• 化学式: C₁₂H₇Cl₃N₂O
• mdl: MFCD00784167
• 分子量: 301.559
• InChiKey: YQRXTNQUPCQTPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  烟酸 、 2,4,5-三氯苯胺 在 silica gel 作用下， 以 5,5-dimethyl-1,3-cyclohexadiene 为溶剂， 以72%的产率得到N-(2,4,5-trichlorophenyl)pyridine-3-carboxamide
  参考文献：
  名称：

  A Convenient One-Pot Synthesis and Nematicidal Activity of Nicotinic Acid Amides

  摘要：

  Seven nicotinic acid amides were synthesized by condensation of nicotinic acid adsorbed on silica gel with different aromatic amines. The synthesized compounds were characterized by H-1 and C-13 NMR and IR spectroscopy and screened for their nematicidal activity against root knot nematode Meloidogyne incognita by egg hatching and mortality test. All compounds exhibited significant nematicidal potential as compared to control. Maximum egg hatching inhibition potential was exhibited by N-(4-bromophenyl)nicotinamide while N-(2,4,5-trichlorophenyl)nicotinamide showed the maximum mortality potential.

  DOI：

  10.1134/s1070428019060150

文献信息

• A Convenient One-Pot Synthesis and Nematicidal Activity of Nicotinic Acid Amides
  作者：N. Jain、D. Utreja、N. K. Dhillon

  DOI：10.1134/s1070428019060150

  日期：2019.6

  Seven nicotinic acid amides were synthesized by condensation of nicotinic acid adsorbed on silica gel with different aromatic amines. The synthesized compounds were characterized by H-1 and C-13 NMR and IR spectroscopy and screened for their nematicidal activity against root knot nematode Meloidogyne incognita by egg hatching and mortality test. All compounds exhibited significant nematicidal potential as compared to control. Maximum egg hatching inhibition potential was exhibited by N-(4-bromophenyl)nicotinamide while N-(2,4,5-trichlorophenyl)nicotinamide showed the maximum mortality potential.