2-(benzhydrylthio)propionamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(benzhydrylthio)propionamide
• 英文别名: 2-Benzhydrylsulfanylpropanamide
• 化学式: C₁₆H₁₇NOS
• 分子量: 271.383
• InChiKey: NWFWWNZOICSEDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  68.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(benzhydrylthio)propionamide 、 双氧水 以 水 、 溶剂黄146 为溶剂， 以60%的产率得到2-(benzhydrylsulphinyl)propionamide
  参考文献：
  名称：

  Acetamide derivatives and their use as feeding behaviour modifiers

  摘要：

  本发明涉及式（I）化合物，其中R.sub.1从H和3-氯中选择；R.sub.2从苯基和吡啶基中选择；R.sub.3和R.sub.4可独立地从H和甲基中选择；R.sub.5和R.sub.6可独立地从H和吡啶基-甲基或两者都代表乙基中选择；n=0或1；当R.sub.2为苯基时，R.sub.1、R.sub.3、R.sub.4、R.sub.5和R.sub.6不同时为H。还公开了含有药用可接受酸的化合物的吡啶基盐。

  公开号：

  US05719168A1

文献信息

• DERIVES D'ACETAMIDE ET LEUR UTILISATION COMME MODIFICATEURS DU COMPORTEMENT DE PRISE ALIMENTAIRE
  申请人：LABORATOIRE L. LAFON

  公开号：EP0706512B1

  公开（公告）日：1998-04-08
• US5719168A
  申请人：——

  公开号：US5719168A

  公开（公告）日：1998-02-17
• [EN] ACETAMIDE DERIVATIVES AND THEIR USE FOR MODIFYING FEEDING BEHAVIOUR MODIFIERS<br/>[FR] DERIVES D'ACETAMIDE ET LEUR UTILISATION COMME MODIFICATEURS DU COMPORTEMENT DE PRISE ALIMENTAIRE
  申请人：LABORATOIRE L. LAFON

  公开号：WO1995001333A1

  公开（公告）日：1995-01-12

  (EN) The present invention relates to compounds of formula (I) wherein R1 is selected from H and 3-chloro; R2 is selected from a phenyl group and a pyridyl group; R3 and R4 are selected independently of each other from H and methyl; R5 and R6 are selected independently of each other from H and a pyridyl-methyl group or both represent an ethyl group; n = 0 or 1; R1, R3, R4, R5 and R6 are not simultaneously H when R2 is phenyl. The salts of the compounds having a pyridyl group with pharmaceutical acceptable acids are also disclosed.(FR) La présente invention concerne des composés de formule (I) dans laquelle: R1 est choisi parmi H et 3-chloro, R2 est choisi parmi un groupe phényle et un groupe pyridyle, R3 et R4 sont choisis indépendamment l'un de l'autre parmi H et méthyle, R5 et R6 sont choisis indépendamment l'un de l'autre parmi H et un groupe pyridyl-méthyle ou représentent tous les deux un groupe éthyle, n = 0 ou 1, R1, R3, R4, R5 et R6 n'étant pas simultanément H quand R2 = phényle, et les sels des composés à groupe pyridyle avec des acides pharmaceutiquement acceptables.
• [EN] PROCESS FOR THE PREPARATION OF 2-[(DIPHENYLMETHYL) THIO] ACETAMIDE<br/>[FR] PROCEDE DE PREPARATION DE 2-[(DIPHENYLMETHYL)THIOACETAMIDE
  申请人：ALEMBIC LTD

  公开号：WO2004075827A2

  公开（公告）日：2004-09-10

  Process for the preparation of 2-[(diphenylmethyl)thioacetamide, an intermediate for the preparation of Modafinil which is a CNS stimulant and used for the treatment of narcolepsia. The process comprises reacting 2-[(diphenylmethyl)thio]acetic acid with alcohols, in presence of catalytic amount of inorganic acid or organic acid at reflux temperature of alcohol to obtain corresponding ester which is reacted with ammonia to give 2-[(diphenylmethyl)thio]acetamide. If desired 2-[(diphenylmethyl)thioacetamide thus produced is reacted with hydrogen peroxide to produce Modafinil.
• Acetamide derivatives and their use as feeding behaviour modifiers
  申请人：Laboratoire L. Lafon

  公开号：US05719168A1

  公开（公告）日：1998-02-17

  The present invention relates to compounds of formula (I) wherein R.sub.1 is selected from H and 3-chloro; R.sub.2 is selected from a phenyl group and a pyridyl group; R.sub.3 and R.sub.4 are selected independently of each other from H and methyl; R.sub.5 and R.sub.6 are selected independently of each other from H and a pyridyl-methyl group or both represent an ethyl group; n=0 or 1; R.sub.1, R.sub.3, R.sub.4, R.sub.5 and R.sub.6 are not simultaneously H when R.sub.2 is phenyl. The salts of the compounds have a pyridyl group with pharmaceutical acceptable acids are also disclosed.

  本发明涉及式（I）化合物，其中R.sub.1从H和3-氯中选择；R.sub.2从苯基和吡啶基中选择；R.sub.3和R.sub.4可独立地从H和甲基中选择；R.sub.5和R.sub.6可独立地从H和吡啶基-甲基或两者都代表乙基中选择；n=0或1；当R.sub.2为苯基时，R.sub.1、R.sub.3、R.sub.4、R.sub.5和R.sub.6不同时为H。还公开了含有药用可接受酸的化合物的吡啶基盐。