5-{2-[2-(2-methoxyphenoxy)-ethylamino]-1-phenylthioethyl}-2-methylbenzenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 5-{2-[2-(2-methoxyphenoxy)-ethylamino]-1-phenylthioethyl}-2-methylbenzenesulfonamide
• 英文别名: 5-{2-[2-(2-methoxyphenoxy)ethylamino]-1-phenylthioethyl}-2-methylbenzenesulfonamide；5-[2-[2-(2-methoxyphenoxy)ethylamino]-1-phenylsulfanylethyl]-2-methylbenzenesulfonamide
• 化学式: C₂₄H₂₈N₂O₄S₂
• 分子量: 472.629
• InChiKey: GPYZWPRRCJSGJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  124
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  5-{2-[2-(2-methoxyphenoxy)-ethylamino]-1-phenylthioethyl}-2-methylbenzenesulfonamide 生成 5-{2-[2-(2-methoxyphenoxy)-ethylamino]-1-phenylsulfinylethyl}-2-methylbenzenesulfonamide
  参考文献：
  名称：

  IMAI, KAZUO;NIIGATA, KUNIHIRO;FUJIKURA, TAKASHI;HASHIMOTO, SHINICHI;TAKEN+

  摘要：

  DOI：
• 作为产物：
  描述：

  5-[1-[2-(2-methoxyphenoxy)ethyl]aziridin-2-yl]-2-methylbenzenesulfonamide;hydrochloride 、 苯硫酚 生成 5-{2-[2-(2-methoxyphenoxy)-ethylamino]-1-phenylthioethyl}-2-methylbenzenesulfonamide
  参考文献：
  名称：

  IMAI, KAZUO;NIIGATA, KUNIHIRO;FUJIKURA, TAKASHI;HASHIMOTO, SHINICHI;TAKEN+

  摘要：

  DOI：

文献信息

• Sulfamoyl-substituted phenethylamine derivatives, their preparation, and
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04731478A1

  公开（公告）日：1988-03-15

  A novel process is provided for the preparation of optical isomers of certain sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking agents which can be used for various treatments such as for the treatment of congestive heart failure.

  提供了一种新颖的工艺，用于制备具有α-肾上腺素受体阻滞剂性质的某些磺胺基取代苯乙胺衍生物的光学异构体，可用于各种治疗，如治疗充血性心力衰竭。
• Sulfamoyl-substituted phenethylamine derivatives and process of
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04373106A1

  公开（公告）日：1983-02-08

  Novel sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking action and are useful as an antihypertensive agent and an agent for the treatment of congestive heart failure.

  新型磺胺基取代的苯乙胺衍生物，具有α-肾上腺素受体阻滞作用，可用作降压药和治疗充血性心力衰竭的药物。
• Sulfamoyl substituted phenethylamine intermediates
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US05391825A1

  公开（公告）日：1995-02-21

  Pharmaceutical compositions are provided for the treatment of disorders in a subject, such as hypertension, congestive heart failure, angina pectoris, lower urinary tract dysfunction and prostatic hypertrophy. The compositions when administered to a subject produce an .alpha.-adrenergic blocking action and contain as an active ingredient sulfamoyl-substituted phenethylamine derivatives, such as optically active 5-2-[2-(2-ethoxyphenoxy)ethylamino]-2-methylethyl-2-methoxybenzenesulfonam ide, and a pharmaceutically acceptable carrier.

  提供了用于治疗主题中的疾病（例如高血压、充血性心力衰竭、心绞痛、下尿路功能障碍和前列腺肥大）的药物组合物。当给主题施用该组合物时，会产生α-肾上腺素受体阻滞作用，其活性成分为磺酰基取代的苯乙胺衍生物，例如光学活性的5-2-[2-(2-乙氧基苯氧基)乙基氨基]-2-甲基乙基-2-甲氧基苯磺酰胺，以及药用载体。
• Sulfamoyl substituted phenethylamine derivatives and process of
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04703063A1

  公开（公告）日：1987-10-27

  Novel sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking action and are useful as an antihypertensive agent and an agent for the treatment of congestive heart failure.

  小说磺胺基取代的苯乙胺衍生物，具有α-肾上腺素能阻滞作用，可用作降压剂和治疗充血性心力衰竭的药物。
• Use of sulfamoyl-substituted phenethylamine derivatives in treatment of
  申请人：Yamanouchi Pharmaceutical Co., Ltd.

  公开号：US04987152A1

  公开（公告）日：1991-01-22

  Novel sulfamoyl-substituted phenethylamine derivatives which exhibit .alpha.-adrenergic blocking action and are useful as an antihypertensive agent and an agent for the treatment of congestive heart failure.

  这是一种新型磺酰基取代的苯乙胺衍生物，具有α-肾上腺素受体阻滞作用，可用作降压药和治疗充血性心力衰竭的药物。