二乙基饭匙倩碱 | 13473-61-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 二乙基饭匙倩碱
• 英文名称: methylbenactyzine
• 英文别名: Diphenyl-glykolsaeure-<2-(methyl-di-aethyl-ammonio)-aethylester>；Methylbenactyzium；diethyl-[2-(2-hydroxy-2,2-diphenylacetyl)oxyethyl]-methylazanium
• CAS: 13473-61-5
• 化学式: C₂₁H₂₈NO₃
• 分子量: 342.458
• InChiKey: HDAMOICMOAXFLJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

安全信息

• 海关编码：
  2923900090

文献信息

• Bicyclic compound
  申请人：Miyoshi Shiro

  公开号：US20060069098A1

  公开（公告）日：2006-03-30

  A novel compound represented by the following formula (1) or a salt thereof: wherein symbol “A” represents a saturated heterocyclic group, a 5-membered heteroaromatic group having two heteroatoms in the ring, a group represented by the formula A1 (R 2 , R 3 , and R 4 represent hydrogen atom, hydroxyl group, etc.), etc., B represents a group represented by the formula B1 (R 11 represents hydrogen atom, hydroxyl group, etc.), etc., R 1 represents an alkyl group, and symbol “n” represents an integer of 2 to 6, which has a parathyroid hormone depressing action and showing low toxicity, and a medicament containing the compound or salt thereof as an active ingredient.

  以下公式（1）所代表的一种新化合物或其盐：其中符号“A”代表饱和杂环基，一个含有两个杂原子的5元杂芳基，一个由公式A1（R2、R3和R4代表氢原子、羟基等）所代表的基团，等等，B代表由公式B1（R11代表氢原子、羟基等）所代表的基团，等等，R1代表烷基，符号“n”代表一个整数，范围为2至6，具有降钙素抑制作用和低毒性，并且含有该化合物或其盐作为活性成分的药物。
• WATER-SOLUBLE LIQUID INTERNAL MEDICINE
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP1336408A1

  公开（公告）日：2003-08-20

  A water-soluble oral solution comprising famotidine and edetic acid or a salt thereof.

  一种水溶性口服溶液，由法莫替丁和依地酸或其盐组成。
• COMPOSITION FOR ENHANCING INDUCTION OF HUMORAL IMMUNITY, AND VACCINE PHARMACEUTICAL COMPOSITION
  申请人：Nitto Denko Corporation

  公开号：EP3178491A1

  公开（公告）日：2017-06-14

  The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.

  本发明旨在提供一种促进体液免疫诱导的组合物和一种疫苗药物组合物，该组合物可普遍用于各种抗原的体液免疫诱导抗原，含有Th2反应促进剂，并能发挥较高的体液免疫诱导效果。本发明涉及一种疫苗药物组合物，它含有用于诱导体液免疫的抗原和至少一种 Th2 反应促进剂。
• Method and apparatus for dry granulation
  申请人：ATACAMA LABS OY

  公开号：US10265272B2

  公开（公告）日：2019-04-23

  A dry-granulation method for producing a tablet comprising (a) pharmaceutical active ingredient in an amount 50-90% w/w and (b) one or more excipients in an amount 10-50% w/w including at least a binder which comprises (i) preparing granules from a powder comprising a binder, a pharmaceutically active ingredient and optionally one or more other excipients or pharmaceutical active ingredients by a process characterized in that a compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the granules by entraining the fine particles and/or small granules in a gas stream in which the compacted mass flows, wherein the direction of the flow of the gas stream has a component which is contrary to that of the direction of flow of the compacted mass, and collecting the accepted granules (ii) blending the accepted granules with other components of the tablet in granular or fine powder form wherein in step (ii) at least one other component of the tablet formulation is in granular form and is prepared from a powder comprising said other component by a process characterized in that a compaction force is applied to the powder to produce a compacted mass comprising a mixture of fine particles and granules and separating and removing fine particles and/or small granules from the granules by entraining the fine particles and/or small granules in a gas stream in which the compacted mass flows, wherein the direction of the flow of the gas stream has a component which is contrary to that of the direction of flow of the compacted mass; and (iii) compressing the resultant blend to form a tablet; with the proviso that the tablet does not comprise (a) paracetamol, maize starch and microcrystalline cellulose in a ratio of 60:20:20 w/w, (b) acebutolol HCl and starch in a ratio of 90:10 w/w, (c) sodium valproate, hypromellose and maize starch in a ratio of 90:5:5 w/w, (d) ketoprofen and maize starch in a ratio of 50:50 w/w or (e) metformin HCl, microcrystalline cellulose and maize starch in a ratio of 80:14:6 w/w.

  一种生产片剂的干制粒方法，该片剂包含(a)重量百分比为 50-90%的药物活性成分和(b)重量百分比为 10-50%的一种或多种赋形剂，其中至少包括一种粘合剂，该方法包括(i)用包含粘合剂的粉末制备颗粒、(i) 从粉末中制备颗粒，该粉末包括粘合剂、药用活性成分和一种或多种其它辅料或药用活性成分，制备工艺的特点是对粉末施加压实力以产生由细小颗粒和颗粒混合物组成的压实物，并通过将细小颗粒和/或小颗粒夹带在压实物流动的气流中，将细小颗粒和/或小颗粒从颗粒中分离和去除，其中气流的流动方向与压实物的流动方向相反、收集所接受的颗粒 (ii) 将所接受的颗粒与颗粒状或细粉末状的片剂的其他成分混合，其中在步骤(ii)中，片剂配方中的至少一种其他成分为颗粒状，由包含所述其他成分的粉末制备而成，其特征在于，对粉末施加压实力以产生包含细颗粒和颗粒混合物的压实物，并通过在压实物流动的气流中夹带细颗粒和/或小颗粒，从颗粒中分离和去除细颗粒和/或小颗粒、其中，气流的流动方向与压实物的流动方向相反；(iii) 压缩所得混合物以形成片剂；但片剂不包括 (a) 对乙酰氨基酚、玉米淀粉和微晶纤维素的重量比为 60：20:20 w/w，(b)盐酸醋丁洛尔和淀粉的比例为 90:10 w/w，(c)丙戊酸钠、 低聚异麦芽糖和玉米淀粉的比例为 90:5:5 w/w，(d)酮洛芬和玉米淀粉的比例为 50:50 w/w，或(e)盐酸二甲双胍、微晶纤维素和玉米淀粉的比例为 80:14:6 w/w。
• Composition for enhancing induction of humoral immunity, and vaccine pharmaceutical composition
  申请人：NITTO DENKO CORPORATION

  公开号：US10369219B2

  公开（公告）日：2019-08-06

  The present invention aims to provide a composition for promoting humoral immunity induction and a vaccine pharmaceutical composition that can be universally used for various antigens in inducing humoral immunity to antigens, contain a Th2 reaction promoter, and exerts a high humoral immunity inducing effect. The present invention relates to a vaccine pharmaceutical composition containing an antigen for humoral immunity induction and at least one Th2 reaction promoter.

  本发明旨在提供一种促进体液免疫诱导的组合物和一种疫苗药物组合物，该组合物可普遍用于各种抗原的体液免疫诱导抗原，含有Th2反应促进剂，并能发挥较高的体液免疫诱导效果。本发明涉及一种疫苗药物组合物，它含有用于诱导体液免疫的抗原和至少一种 Th2 反应促进剂。