7-(p-methoxyphenyl)-2-methoxy-3-methylpyrido[2,3-d]pyrimidin-4(3H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 7-(p-methoxyphenyl)-2-methoxy-3-methylpyrido[2,3-d]pyrimidin-4(3H)-one
• 英文别名: 2-Methoxy-7-(4-methoxyphenyl)-3-methylpyrido[2,3-d]pyrimidin-4-one
• 化学式: C₁₆H₁₅N₃O₃
• 分子量: 297.313
• InChiKey: PEONHLWYWIHEGA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  64
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-氨基-2-甲氧基-3-甲基-4(3H)-嘧啶酮 、 1-(4-甲氧基苯基)-3-二甲氨基-1-丙酮盐酸盐 以 乙醇 为溶剂， 以60%的产率得到7-(p-methoxyphenyl)-2-methoxy-3-methylpyrido[2,3-d]pyrimidin-4(3H)-one
  参考文献：
  名称：

  New aspects on the selective synthesis of 7-arylpyrido[2,3-d]pyrimidines

  摘要：

  Pyrido[2,3-d]pyrimidines have been synthesized via a selective cyclocondensation reaction between 6-aminopyrimidines 1 and the Mannich bases, propiophenone hydrochlorides 2. Intermediates for this reaction, such as the Michael addition adduct and the further hydrated pyrido[2,3-d]pyrimidine were isolated to prove the postulated mechanism. NMR analysis of bidimensional experiments allowed to determine unambiguously the process to obtain 7-arylpyrido[2,3-d]pyrimidines. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(02)00433-7

文献信息

• New aspects on the selective synthesis of 7-arylpyrido[2,3-d]pyrimidines
  作者：Jairo Quiroga、Henry Insuasty、Braulio Insuasty、Rodrigo Abonı́a、Justo Cobo、Adolfo Sánchez、Manuel Nogueras

  DOI：10.1016/s0040-4020(02)00433-7

  日期：2002.6

  Pyrido[2,3-d]pyrimidines have been synthesized via a selective cyclocondensation reaction between 6-aminopyrimidines 1 and the Mannich bases, propiophenone hydrochlorides 2. Intermediates for this reaction, such as the Michael addition adduct and the further hydrated pyrido[2,3-d]pyrimidine were isolated to prove the postulated mechanism. NMR analysis of bidimensional experiments allowed to determine unambiguously the process to obtain 7-arylpyrido[2,3-d]pyrimidines. (C) 2002 Elsevier Science Ltd. All rights reserved.