dimethyl (m-phenoxyphenyl-N-phenylaminomethyl)phosphonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethyl (m-phenoxyphenyl-N-phenylaminomethyl)phosphonate
• 英文别名: N-[dimethoxyphosphoryl-(3-phenoxyphenyl)methyl]aniline
• 化学式: C₂₁H₂₂NO₄P
• 分子量: 383.384
• InChiKey: PFQRPPWJAYQJOA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  56.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  亚磷酸二甲酯 、 N-phenyl-m-phenoxybenzylideneamine 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 2.0h， 以62%的产率得到dimethyl (m-phenoxyphenyl-N-phenylaminomethyl)phosphonate
  参考文献：
  名称：

  Synthesis and Reactions of Azomethines Containing a m-Phenoxyphenyl Group: II. Chemical Transformations >of N-Aryl-m-phenoxyphenylmethanimines and Arylhydrazones of m-Phenoxybenzaldehyde

  摘要：

  Chemical transformations of N-aryl-m-phenoxyphenylmethanimines and m-phenoxybenzaidehyde arythydrazones were studied by examples of reduction thereof with complex metal hydrides and reactions with dialkyl phosphates and dialkyl phosphites.

  DOI：

  10.1023/b:rujo.0000043714.74375.30

文献信息

• One-Pot Synthesis of α-Aminophosphonates: An Inexpensive Approach
  作者：A. Manjula、B. Vittal Rao、Parvathi Neelakantan

  DOI：10.1081/scc-120022468

  日期：2003.9.1

  Abstract A one-pot synthesis of the α-aminophosphonates from aldehydes and amines using trimethyl phosphite catalyzed by aluminum chloride at ambient temperature is reported. #IICT Communication No. 20412.

  摘要 报道了在室温下，在氯化铝的催化下，使用亚磷酸三甲酯由醛和胺一锅法合成 α-氨基膦酸酯。#IICT 通讯第 20412 号。
• (Bromodimethyl)sulfonium bromide: an inexpensive reagent for the solvent-free, one-pot synthesis of α-aminophosphonates
  作者：Sucheta Kudrimoti、Vittal Rao Bommena

  DOI：10.1016/j.tetlet.2004.12.070

  日期：2005.2

  A novel solvent-free, one-pot synthesis of α-aminophosphonates in the presence of catalytic (bromodimethyl)sulfonium bromide at room temperature in high yields is reported.

  报道了在室温下高产率地在催化的（溴二甲基）溴化presence存在下无溶剂的一锅法合成α-氨基膦酸酯的新方法。
• Synthesis and Reactions of Azomethines Containing a m-Phenoxyphenyl Group: II. Chemical Transformations >of N-Aryl-m-phenoxyphenylmethanimines and Arylhydrazones of m-Phenoxybenzaldehyde
  作者：Yu. V. Popov、T. K. Korchagina、G. V. Chicherina、T. A. Ermakova

  DOI：10.1023/b:rujo.0000043714.74375.30

  日期：2004.5

  Chemical transformations of N-aryl-m-phenoxyphenylmethanimines and m-phenoxybenzaidehyde arythydrazones were studied by examples of reduction thereof with complex metal hydrides and reactions with dialkyl phosphates and dialkyl phosphites.