N-(3-hydroxyimino-2-methyl-3-phenylpropyl-2)hydroxylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(3-hydroxyimino-2-methyl-3-phenylpropyl-2)hydroxylamine
• 英文别名: 2-(Hydroxyamino)-2-methyl-1-phenyl-propan-1-one oxime；(NE)-N-[2-(hydroxyamino)-2-methyl-1-phenylpropylidene]hydroxylamine
• 化学式: C₁₀H₁₄N₂O₂
• 分子量: 194.233
• InChiKey: FLVMMVWWXZODIT-PKNBQFBNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  64.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(3-hydroxyimino-2-methyl-3-phenylpropyl-2)hydroxylamine 在 manganese(IV) oxide 、 ammonium acetate 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 14.0h， 生成
  参考文献：
  名称：

  乙酸铵作为空间位阻官能化羟胺与酮缩合的催化剂

  摘要：

  发现乙酸铵是 α-羟基氨基肟和 α-羟基氨基醇与酮缩合的催化剂。这种缩合导致空间位阻杂环羟胺，它是稳定的氮氧化合物的前体。

  DOI：

  10.1007/bf02502943

文献信息

• Interaction of heterocyclic nitrones with organometallic reagents as a method for the synthesis of new types of nitroxides
  作者：Vladimir A. Reznikov、Leonid B. Volodarsky

  DOI：10.1016/s0040-4020(01)81557-x

  日期：1993.1

  The reactions of heterocyclic nitroxides: 3-imidazoline-3-oxides, 2H- (4H)-imidazole mono- and dioxides, dihydropyrazine-1,4-dioxides, with organometallic reagents and subsequent oxidation led to heterocyclic nitroxides of 3-(2)-imidazoline and 3-(2)-imidazoline-3-oxide, dihydropyrazine oxide, monocyclic imidazolidine biradicals and stable acyclic nitroxides with hydrogen at the α-carbon atom.

  杂环氮氧化物的反应：3-咪唑啉-3-氧化物，2H-（4H）-咪唑单和二氧化物，二氢吡嗪-1,4-二氧化物与有机金属试剂的反应以及随后的氧化反应生成3-（2）杂环氮氧化物-咪唑啉和3-（2）-咪唑啉-3-氧化物，二氢吡嗪氧化物，单环咪唑烷双自由基和稳定的无环氮氧化物，氢在α-碳原子处。
• Synthesis and Inhibitory Effect on Platelet Aggregation and Antihypertensive Activity of 1-Hydroxy-2,5-dihydro-1H-imidazole-2- carboxylic Acid 3-Oxides, 1,3-Dihydroxyimidazolidine-2-carboxylic Acids, and 1,4-Dihydroxy-2,3-piperazinediones
  作者：Aleksei Ya. Tikhonov、Dmitrii G. Mazhukin、Larisa N. Grigor′eva、Vadim K. Khlestkin、Natal′ya N. Voinova、Boris Ya. Syropyatov、Svetlana S. Shirinkina、Leonid B. Volodarsky

  DOI：10.1002/(sici)1521-4184(19999)332:9<305::aid-ardp305>3.0.co;2-2

  日期：1999.9

  The reaction of 1,2-hydroxylamino-oximes 1 with pyruvic or glyoxylic acid and of 1,2-bishydroxylamines 4 with glyoxylic acid resulted in 2,5-dihydro-1H-imidazole-2-carboxylic acid 3-oxides 2 and 2-imidazolidinecarboxylic acids 5, respectively. It was found that hydroxylamino acids 2 and 1,4-dihydroxy-2,3-piperazinediones 7 showed marked inhibitory effect on platelet aggregation. 1-Hydroxy-2-methyl-1,5,6,7,8,8a-hexahydro-2H,4H-cycloheptimidazole -2-carboxylic acid 3-oxide 2e exhibited antihypertensive activity.
• Ammounium acetate as a catalyst of the condensation of sterically hindered functionalized hydroxylamines with ketones
  作者：V. A. Reznikov、L. B. Volodarsky

  DOI：10.1007/bf02502943

  日期：1997.9

  Ammonium acetate was found to be a catalyst of the condensation of α-hydroxylamino oximes and α-hydroxylamino alcohols with ketones. This condensation leads to sterically hindered heterocyclic hydroxylamines, which are precursors of stable nitroxides.

  发现乙酸铵是 α-羟基氨基肟和 α-羟基氨基醇与酮缩合的催化剂。这种缩合导致空间位阻杂环羟胺，它是稳定的氮氧化合物的前体。