tropenol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: tropenol
• 英文别名: (1S,5S)-8-methyl-8-azabicyclo[3.2.1]oct-2-en-1-ol
• 化学式: C₈H₁₃NO
• 分子量: 139.197
• InChiKey: HWACEPZXFJTFSW-HTQZYQBOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  23.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  tropenol 、 methyl 4,4'-difluorobenzilate 在 sodium 作用下， 生成 tropenol 4,4'-difluorobenzilate
  参考文献：
  名称：

  Anticholinergics which may be used as medicaments as well as processes for preparing them

  摘要：

  本发明涉及一般式11的新抗胆碱药物，其中A、X-以及基团R1、R2、R3、R4、R5、R6和R7可能具有声明和说明书中给定的含义，以及制备它们的过程和它们作为药物组合物的用途。

  公开号：

  US20020115680A1

文献信息

• Medicaments for inhalation comprising a novel anticholinergic and a betamimetic
  申请人：Germeyer Sabine

  公开号：US20050107417A1

  公开（公告）日：2005-05-19

  A pharmaceutical composition comprising a compound of formula 1 wherein X − is an anion with a single negative charge, and a betamimetic, optionally together with a pharmaceutically acceptable excipient, the compound of formula 1 and the betamimetic optionally in the form of their enantiomers, mixtures of their enantiomers, their racemates, their solvates, or their hydrates, processes for preparing them, and their use in the treatment of respiratory tract diseases.

  一种药物组合物，包括公式1中的化合物，其中X-是带有单负电荷的阴离子，以及一种β-肾上腺素受体激动剂，可选地与药用可接受的赋形剂一起使用，公式1中的化合物和β-肾上腺素受体激动剂可选地以它们的对映体、对映体混合物、拉氏体、溶剂化物或水合物的形式存在，制备它们的过程，以及它们在呼吸道疾病治疗中的应用。
• Fluorenecarboxylic acid esters, process for the manufacture thereof, and use thereof as medicaments
  申请人：Boehringer Ingelheim Pharma KG

  公开号：US20030199539A1

  公开（公告）日：2003-10-23

  Flourenecarboxylic acid esters of general formula 1 1 wherein X − and the groups A, R, R 1 , R 2 , R 3 , R 3′ , R 4 , and R 4′ have the meanings given in the claims and in the specification, processes for the manufacture thereof and the use thereof as medicaments.

  Flourenecarboxylic acid esters的普通公式为11，其中X−和A、R、R1、R2、R3、R3′、R4和R4′的基团具有权利要求和说明书中所给出的含义，其制造过程及用途作为药物。
• Xanthenecarboxylates, processes for preparing them, and their use as pharmaceutical compositions
  申请人：Boehringer Ingelheim Pharma GmbH Co. KG

  公开号：US20030203928A1

  公开（公告）日：2003-10-30

  Xanthenecarboxylates of formula 1 1 wherein: A is a group selected from 2 X − is an anion with a single negative charge; R is hydroxy, methyl, hydroxymethyl, ethyl, —CF 3 , —CHF 2 , or fluorine; R 1 and R 2 , which are identical or different, are each C 1 -C 5 -alkyl which is optionally substituted by C 3 -C 6 -cycloalkyl, hydroxy, or halogen, or R 1 and R 2 together denote a —C 3 -C 5 -alkylene-bridge; and R 3 , R 4 , R 3′ , and R 4′ , which are identical or different, are each hydrogen, —C 1 -C 4 -alkyl, —C 1 -C 4 -alkyloxy, hydroxy, —CF 3 , —CHF 2 , —CN, —NO 2 , or halogen, or a physiologically acceptable salt thereof, processes for preparing, them and their use in pharmaceutical compositions.

  化学式为11的xanthenecarboxylates，其中：A是从2X-中选择的基团，2X-是带有单负电荷的阴离子；R是羟基，甲基，羟甲基，乙基，-CF3，-CHF2或氟；R1和R2，它们相同或不同，均为C1-C5烷基，可选地被C3-C6环烷基，羟基或卤素取代，或者R1和R2一起表示为-C3-C5-烷基-桥；R3，R4，R3'和R4'，它们相同或不同，均为氢，-C1-C4烷基，-C1-C4烷氧基，羟基，-CF3，-CHF2，-CN，-NO2或卤素，或其生理上可接受的盐，制备它们的过程以及它们在制药组合物中的用途。
• Carbamic acid esters with anticholinergic activity
  申请人：Boehringer Ingelheim Pharma GmbH & Co. KG

  公开号：US20040132760A1

  公开（公告）日：2004-07-08

  A compound of formula 1 1 wherein X − , A, R 1 , R 2 , R 3 , and R 4 may have the meanings given in the claims and in the specification, processes for preparing them, their use in pharmaceutical compositions, and methods of treating patients using them.

  化合物式为11的复合物，其中X−，A，R1，R2，R3和R4可以具有声明和说明书中给出的含义，制备它们的过程，它们在制药组合物中的使用以及使用它们治疗患者的方法。
• New difurylglycolic acid esters, processes for the preparation thereof as well as the use thereof as pharmaceutical compositions
  申请人：Boehringer Ingelheim Pharma GmbH & Co. KG

  公开号：US20030229227A1

  公开（公告）日：2003-12-11

  Difurylglycolic acid esters of the formula 1 1 wherein X − and the groups A, R, R 1 , R 2 , R 3 and R 3′ may have the meanings given in the claims and in the specification, processes for preparing them and their use for treating asthma, COPD, vagally induced sinus bradycardia, heart rhythm disorders, spasms in the gastrointestinal tract, spasms in the urinary tract or menstrual pain.

  该文献描述了公式11的二叠氧基苯基乙酸酯，其中X-和A、R、R1、R2、R3和R3'基团的含义可以参见权利要求和说明书，以及制备它们的过程，以及它们用于治疗哮喘、慢性阻塞性肺病、迷走神经引起的窦性心动过缓、心律失常、胃肠道痉挛、尿路痉挛或月经疼痛的用途。