6-(benzofuran-2-yl)-1-bromonaphthalen-2-ol

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 2-芳基苯并呋喃类黄酮
• 英文名称: 6-(benzofuran-2-yl)-1-bromonaphthalen-2-ol
• 英文别名: 6-(1-Benzofuran-2-yl)-1-bromonaphthalen-2-ol
• 化学式: C₁₈H₁₁BrO₂
• 分子量: 339.188
• InChiKey: DHTQPMDOYAKCDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  21
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  33.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯并呋喃-2-硼酸 、 1,6-二溴-2-萘酚 在 palladium diacetate 四丁基溴化铵 、 potassium carbonate 作用下， 以 四氢呋喃 、 水 为溶剂， 反应 15.0h， 以21%的产率得到6-(benzofuran-2-yl)-1-bromonaphthalen-2-ol
  参考文献：
  名称：

  Regioselective Suzuki coupling of benzofuran or benzothiophene boronic acids and dibromo substituted naphthalenes: synthesis of a potent inhibitor of plasminogen activator inhibitor-1

  摘要：

  An efficient route to the biologically active naphthyl benzofuran derivative is described. The synthesis highlights a regioselective Suzuki coupling of a benzofuran and a dibromo substituted naphthalene. The scope of regioselective Suzuki coupling has been investigated. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.03.090

文献信息

• COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS
  申请人：Carter Michael D.

  公开号：US20100144821A1

  公开（公告）日：2010-06-10

  The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, Aβ protein or α-synuclein protein aggregation.

  本发明涉及化合物和方法，用于治疗蛋白质折叠障碍。在某些实施例中，本发明提供了治疗神经退行性疾病，如阿尔茨海默病、tau病、脑淀粉样血管病、Lewy体病、痴呆症、亨廷顿病和基于朊病毒海绵状脑病的化合物和方法。本发明还提供了化合物、方法和制药组合物，用于抑制tau蛋白、Aβ蛋白或α-突触核蛋白的聚集。
• US8362066B2
  申请人：——

  公开号：US8362066B2

  公开（公告）日：2013-01-29
• [EN] COMPOUNDS AND METHODS FOR TREATING PROTEIN FOLDING DISORDERS<br/>[FR] COMPOSÉS ET PROCÉDÉS POUR TRAITER DES TROUBLES DE REPLIEMENT DE PROTÉINE
  申请人：UNIV KINGSTON

  公开号：WO2008058402A1

  公开（公告）日：2008-05-22

  [EN] The invention is directed to compounds and methods for treating protein folder disorders. In certain embodiments the invention provides compounds and methods for treating neurodegenerative diseases such as Alzheimer's disease, tauopathy, cerebral amyloid angiopathy, Lewy body disease, dementia, Huntington's disease and prion-based spongiform encelopathy. The invention further provides compounds, methods and pharmaceutical compositions for inhibiting tau protein, Aß protein or a-synuclein protein aggregation.
  [FR] L'invention porte sur des composés et des procédés pour traiter des troubles de repliement de protéine. Dans certains modes de réalisation, l'invention propose des composés et des procédés pour traiter des maladies neurodégénératives telles que la maladie d'Alzheimer, la tauopathie, l'angiopathie amyloïde cérébrale, la maladie à corps de Lewy, la démence, la maladie de Huntington et l'encéphalite spongiforme à base de prions. L'invention propose en outre des composés, des procédés et des compositions pharmaceutiques pour inhiber l'agrégation de la protéine tau, de la protéine Ab ou de la protéine a-synucléïne.
• Regioselective Suzuki coupling of benzofuran or benzothiophene boronic acids and dibromo substituted naphthalenes: synthesis of a potent inhibitor of plasminogen activator inhibitor-1
  作者：Zheng Wang、Hassan Elokdah、Geraldine McFarlane、Sherry Pan、Madelene Antane

  DOI：10.1016/j.tetlet.2006.03.090

  日期：2006.5

  An efficient route to the biologically active naphthyl benzofuran derivative is described. The synthesis highlights a regioselective Suzuki coupling of a benzofuran and a dibromo substituted naphthalene. The scope of regioselective Suzuki coupling has been investigated. (c) 2006 Elsevier Ltd. All rights reserved.