4'-ethoxy-(N-benzoylamino)acetanilide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4'-ethoxy-(N-benzoylamino)acetanilide
• 英文别名: hippuric acid p-phenetidide；Hippursaeure-p-phenetidid；N-((4-Ethoxy-phenylcarbamoyl)-methyl)-benzamide；N-[2-(4-ethoxyanilino)-2-oxoethyl]benzamide
• 化学式: C₁₇H₁₈N₂O₃
• 分子量: 298.342
• InChiKey: JKZICWHIKJSSEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  67.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  马尿酸 、 对乙氧基苯胺 在 N-甲基咪唑 、 tetrakis(N-methylimidazol)dichlorosilicium dichloride 作用下， 以 乙腈 为溶剂， 反应 8.0h， 以55%的产率得到4'-ethoxy-(N-benzoylamino)acetanilide
  参考文献：
  名称：

  Complexes of silicon and phosphorus chlorides with nitrogen-containing bases as the condensing agents in the synthesis of amides

  摘要：

  High effectiveness of new condensing agents on the basis of complexes of silicon and phosphorus chlorides with nitrogen-containing bases in the synthesis of amides from carboxylic acids and amines and also in heterocyclization is shown. Factors affecting the readiness of formation of the amide bond and the yields of the final products are established.

  DOI：

  10.1134/s1070363212080099

文献信息

• Waldschmidt-Leitz; Kuehn, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1950, vol. 285, p. 23,31
  作者：Waldschmidt-Leitz、Kuehn

  DOI：——

  日期：——
• Complexes of silicon and phosphorus chlorides with nitrogen-containing bases as the condensing agents in the synthesis of amides
  作者：L. V. Besgubenko、S. E. Pipko、A. D. Sinitsa

  DOI：10.1134/s1070363212080099

  日期：2012.8

  High effectiveness of new condensing agents on the basis of complexes of silicon and phosphorus chlorides with nitrogen-containing bases in the synthesis of amides from carboxylic acids and amines and also in heterocyclization is shown. Factors affecting the readiness of formation of the amide bond and the yields of the final products are established.