1-benzyloxy-4-(p-methoxyphenyl)butane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyloxy-4-(p-methoxyphenyl)butane
• 英文别名: 4-[4-(Benzyloxy)butyl]anisole；1-methoxy-4-(4-phenylmethoxybutyl)benzene
• 化学式: C₁₈H₂₂O₂
• 分子量: 270.371
• InChiKey: KVUDEAAYHBYWKG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-(苄氧基)吡啶 在 magnesium oxide 作用下， 以 甲苯 为溶剂， 反应 25.25h， 生成 1-benzyloxy-4-(p-methoxyphenyl)butane
  参考文献：
  名称：

  PROTECTION OF ALCOHOLS USING 2-BENZYLOXY-1-METHYLPYRIDINIUM TRIFLUOROMETHANESULFONATE: METHYL (R)-(-)-3-BENZYLOXY-2-METHYL PROPANOATE

  摘要：

  DOI：

  10.15227/orgsyn.084.0295

文献信息

• Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
  申请人：The Florida State University Research Foundation, Inc.

  公开号：US07754909B1

  公开（公告）日：2010-07-13

  A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.

  一种对醇进行苄基化的过程包括将2-苄氧基-1-甲基吡啶三氟甲磺酸盐与具有预定沸点的芳香烃溶剂混合；向混合物中加入酸中和剂；将待苄基化的醇与混合物结合；通过加热至高于环境温度使醇与2-苄氧基-1-甲基吡啶三氟甲磺酸盐发生反应以生成苄基化醇；并将苄基化醇与混合物分离。
• Compounds and Methods of Arylmethylation (Benzylation) As Protection For Alcohol Groups During Chemical Synthesis
  申请人：Dudley Gregory

  公开号：US20100324324A1

  公开（公告）日：2010-12-23

  A process for benzylating an alcohol includes mixing 2-benzyloxy-1-methylpyridinium triflate in an aromatic hydrocarbon solvent having a predetermined boiling point; adding an acid scavenger to the mixture; combining the alcohol to be benzylated with the mixture; reacting the alcohol with the 2-benzyloxy-1-methylpyridinium triflate by heating above ambient temperature to generate the benzylated alcohol; and separating the benzylated alcohol from the mixture.

  一种苯甲基化醇的方法包括将2-苄氧基-1-甲基吡啶三氟甲磺酸盐与具有预定沸点的芳香族烃溶剂混合；向混合物中添加酸清除剂；将待苯甲基化的醇与混合物结合；通过加热至高于环境温度使醇与2-苄氧基-1-甲基吡啶三氟甲磺酸盐反应，以生成苯甲基化醇；并从混合物中分离出苯甲基化醇。
• Mix-and-Heat Benzylation of Alcohols Using a Bench-Stable Pyridinium Salt
  作者：Kevin W. C. Poon、Gregory B. Dudley

  DOI：10.1021/jo0602773

  日期：2006.5.1

  2-Benzyloxy-1-methylpyridinium triflate (1) is a stable, neutral organic salt that converts alcohols into benzyl ethers upon warming. The synthesis and reactivity of 1 are described herein. Benzylation of a wide range of alcohols occurs in good to excellent yield.
• US7754909B1
  申请人：——

  公开号：US7754909B1

  公开（公告）日：2010-07-13
• US7915437B2
  申请人：——

  公开号：US7915437B2

  公开（公告）日：2011-03-29