1',2',5',6'-tetrahydro-2,3'-bipyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1',2',5',6'-tetrahydro-2,3'-bipyridine
• 英文别名: 3-(pyridin-2-yl)-1,2,5,6-tetrahydropyridine；3-(2-pyridyl)-1,2,5,6-tetrahydropyridine；5-(pyridin-2-yl)-1,2,3,6-tetrahydropyridine；5-(2-pyridyl)-1,2,3,6-tetrahydropyridine；2-(1,2,5,6-Tetrahydropyridin-3-yl)pyridine；2-(1,2,3,6-tetrahydropyridin-5-yl)pyridine
• 化学式: C₁₀H₁₂N₂
• 分子量: 160.219
• InChiKey: ORBZHPMIKIFVPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  24.9
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1',2',5',6'-tetrahydro-2,3'-bipyridine 、 1-(((2R,3S),2-(2,4-二氟苯基)-3-甲基环氧乙烷-2-基)甲基)-1H-1,2,4-三唑 在 lithium perchlorate trihydrate 作用下， 以 乙腈 为溶剂， 反应 40.0h， 以61.9%的产率得到(2R,3R)-2-(2,4-difluorophenyl)-3-(5',6'-dihydro-2,3'-bipyridin-1'(2'H)-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
  参考文献：
  名称：

  TRIAZOLE DERIVATIVE OR SALT THEREOF

  摘要：

  提供了一种三唑衍生物或其药学上可接受的盐，该三唑衍生物由式（I）表示：其中*表示不对称碳，并采用R构型或S构型；R1表示由式（II）或（III）表示的结构：表示单键或双键，其中Y表示氢原子或氧原子；R2和R3各自独立地表示氢原子，烷基，芳基，烷氧基，甲酰基，羧基，烷基羰基，芳基羰基，烷氧羰基，氨基，烷基羰胺基，芳基羰胺基，氰基，硝基或卤素原子。

  公开号：

  US20090299071A1
• 作为产物：
  描述：

  5',6'-dihydro-[2,3'-bipyridine]-1'(2'H)-carboxylic acid tert-butyl ester 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 生成 1',2',5',6'-tetrahydro-2,3'-bipyridine
  参考文献：
  名称：

  2-吡啶取代脲结构小分子化合物及其合成和应用

  摘要：

  本发明涉及2‑吡啶取代脲结构小分子化合物及其合成和应用。具体地，本发明公开了式(I)所述的化合物，其对映异构体、非对映异构体、外消旋体或其混合物，或其药学上可接受的盐、水合物及溶剂合物及其制备方法和在制备ASK1小分子抑制剂，或预防和/或治疗与ASK1相关疾病，尤其是肝脏疾病、肺部疾病、心血管疾病、肾脏疾病和代谢性疾病的药物中的用途。

  公开号：

  CN110818683B

文献信息

• Benzoxazepine derivatives and their salts and medicaments containing the same
  申请人：Suntory Limited

  公开号：US06187769B1

  公开（公告）日：2001-02-13

  A benzoxazepine derivative having the general formula (I) and its salts and medicaments containing the same as effective ingredients: wherein, n is an integer of 2 to 5, R1 indicates a hydrogen atom, halogen atom, C1 to C4 lower alkyl group, C1 to C4 lower alkoxyalkyl group, C1 to C4 halogenoalkyl group, cyano group, or ester group, R2 indicates a hydrogen atom, halogen atom, C1 to C4 lower alkyl group, C1 to C4 lower alkoxy group, or hydroxy group, a dotted line indicates the presence or absence of a binding bond, W indicates C, CH, or CH2 or a nitrogen atom, provided that, when W is a nitrogen atom, Z is bonded to W and the dotted line indicates the absence of a bond, and Z indicates an unsubstituted or substituted aromatic hydrocarbon ring group or an unsubstituted or substituted heterocyclic group). This benzoxazepine derivative and its salts are useful as medicaments for the treatment of anxiety neurosis, phobias, obsessive-compulsive disorders, schizophrenia, post-cardiac trauma stress, depression, psychosomatic and other psychoneurotic disorders, eating disorders, menopausal disorders, infantile autism and also emesis or disorders involving the cerebral circulatory system accompanying cerebral infarction and cerebral hemorrhage.

  一种具有通式（I）的苯并噁唑啉衍生物及其盐和含有相同有效成分的药物： 其中，n为2至5的整数，R1表示氢原子、卤原子、C1至C4的低碳基团、C1至C4的低碳氧基碳基团、C1至C4的卤代烷基团、氰基或酯基，R2表示氢原子、卤原子、C1至C4的低碳基团、C1至C4的低碳氧基团或羟基，虚线表示结合键的存在或缺失，W表示C、CH或CH2或氮原子，但当W为氮原子时，Z与W结合，虚线表示缺少结合，Z表示未取代或取代的芳香烃环基团或未取代或取代的杂环基团）。 这种苯并噁唑啉衍生物及其盐可用作治疗焦虑神经症、恐惧症、强迫症、精神分裂症、心脏创伤后应激、抑郁症、心身疾病和其他精神神经病性障碍、进食障碍、更年期障碍、婴儿孤独症以及伴有脑梗死和脑出血的脑循环系统紊乱或呕吐症的药物。
• Pyrazolopyrimidines, a process for their preparation and their use as medicine
  申请人：Danysz Wojciech

  公开号：US20080032998A1

  公开（公告）日：2008-02-07

  Substituted pyrazolopyrimidine derivatives of formula (I) wherein R 1 represents chloro or bromo; R 2 , R 3 , R 4 , R 5 , R 6 and R 7 independently represent e.g. hydrogen or C 1-6 -alkyl; R 8 represents a radical R 9 or a radical R 10 , whereby one of the two radicals R 8 represents R 9 and the other radical R 8 represents Ret; R 9 represents e.g. a phenyl or thiophene group, and R 10 represents e.g. hydrogen or methyl; are potent mGluR5 modulators and are useful for the prevention of acute and chronic neurological disorders.

  取代吡唑并嘧啶衍生物的公式(I) 其中 R1代表氯或溴； R2、R3、R4、R5、R6和R7独立代表例如氢或C1-6-烷基； R8代表R9的基团或R10的基团，其中两个R8基团之一代表R9，另一个R8基团代表Ret；R9代表例如苯基或噻吩基团，R10代表例如氢或甲基； 是有效的mGluR5调节剂，可用于预防急性和慢性神经障碍。
• Pyridyltetrahydropyridines and pyridylpiperidines and method of manufacturing them
  申请人：Kuwabara Hirokazu

  公开号：US20070093528A1

  公开（公告）日：2007-04-26

  The present invention provides pyridine derivatives useful as intermediates of drugs and agricultural chemicals, electrophotographic receptors, dyes and so on. More specifically, the invention relates to novel pyridyltetrahydropyridines and novel pyridylpiperidines, and further to a method of manufacturing pyridine derivatives through reaction between bipyridine derivatives and benzyl halide or benzyloxycarbonyl halide and subsequent reduction of the resultant reaction products with the aid of palladium catalysts, platinum catalysts, ruthenium catalysts or rhodium catalysts.

  本发明提供了吡啶衍生物，作为药物和农业化学品的中间体，电子照相感受器，染料等。更具体地，本发明涉及新型吡啶基四氢吡啶和新型吡啶基哌啶，以及通过双吡啶衍生物和苯甲醰或苄氧羰基卤化物反应，并在钯催化剂、铂催化剂、钌催化剂或铑催化剂的帮助下还原所得反应产物的吡啶衍生物制备方法。
• Pyridyltetrahydropyridines and Pyridylpiperidines, and Method of Manufacturing Them
  申请人：Kuwabara Hirokazu

  公开号：US20100029947A1

  公开（公告）日：2010-02-04

  The present invention provides pyridine derivatives useful as intermediates of drugs and agricultural chemicals, electrophotographic receptors, dyes and so on. More specifically, the invention relates to novel pyridyltetrahydropyridines and novel pyridylpiperidines, and further to a method of manufacturing pyridine derivatives through reaction between bipyridine derivatives and benzyl halide or benzyloxycarbonyl halide and subsequent reduction of the resultant reaction products with the aid of palladium catalysts, platinum catalysts, ruthenium catalysts or rhodium catalysts.

  本发明提供了吡啶衍生物，可用作药物和农业化学品，电子照相受体，染料等的中间体。更具体地说，本发明涉及新型吡啶基四氢吡啶和新型吡啶基哌啶，以及通过双吡啶衍生物和苯甲醰或苄氧羰基卤化物的反应制备吡啶衍生物的方法，并借助钯催化剂、铂催化剂、钌催化剂或铑催化剂还原所得反应产物的方法。
• Triazole derivative or salt thereof
  申请人：Fujifilm Finechemicals Co., Ltd

  公开号：US07973056B2

  公开（公告）日：2011-07-05

  A triazole derivative or pharmaceutically acceptable salt thereof is provided, the triazole derivative being represented by formula (I): wherein * represents an asymmetric carbon and takes R configuration or S configuration; and R1 represents a structure represented by formula (II) or (III): represents single bond or double bond wherein Y represents a hydrogen atom or an oxygen atom; and R2 and R3 each independently represent a hydrogen atom, an alkyl group, an aryl group, an alkoxy group, a formyl group, a carboxyl group, an alkylcarbonyl group, an arylcarbonyl group, an alkoxycarbonyl group, a carbamoyl group, an amino group, an alkylcarbonylamino group, an arylcarbonylamino group, a cyano group, a nitro group or a halogen atom.

  提供了一种三唑衍生物或其药学上可接受的盐，该三唑衍生物由公式（I）表示： 其中*代表不对称碳，并采用R构型或S构型；R1代表由公式（II）或（III）表示的结构：表示单键或双键 其中Y代表氢原子或氧原子；R2和R3各自独立地表示氢原子，烷基，芳基，烷氧基，甲酰基，羧基，烷基羰基，芳基羰基，烷氧羰基，氨基甲酰基，烷基羰胺基，芳基羰胺基，氰基，硝基或卤素原子。