N'-3-[2-(cyclohexyloxy)-ethoxy]phenyl-N-hydroxyurea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N'-3-[2-(cyclohexyloxy)-ethoxy]phenyl-N-hydroxyurea
• 英文别名: 1-[3-(2-Cyclohexyloxyethoxy)phenyl]-3-hydroxyurea
• 化学式: C₁₅H₂₂N₂O₄
• 分子量: 294.351
• InChiKey: YQGNFDGIHXSIQH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  79.8
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N'-3-[2-(cyclohexyloxy)-ethoxy]phenyl-N-hydroxyurea 、 四丁基溴化铵 在 sodium hydroxide 、 硫酸二甲酯 作用下， 以 四氢呋喃 、 甲苯 、 苯 为溶剂， 生成 N-3-[2-(cyclohexyloxy)ethoxy]phenyl-N-methoxy-N-methylurea
  参考文献：
  名称：

  Urea derivatives, and their production and use

  摘要：

  N'-苯基-N-甲基脲类化合物的新颖衍生物的化学式如下：其中R为C4-C10环烷基，C4-C10环烯基，与苯环融合的C4-C10环烷基或至少一个C1-C4烷基取代的C4-C10环烷基，或与苯环融合或取代一个C1-C4烷基的C4-C10环烯基；Z为C1-C4烷基链，端部和/或碳链内可能含有氧和/或硫原子；Y为氧原子或硫原子；A为氢原子，甲基基团或甲氧基团；n为0或1的整数，但在--(Z)n--Y--链中，氧和/或硫原子不得连续存在。这些衍生物对各种杂草显示出显著的除草活性，在种植作物的过程中对哺乳动物没有显著毒性，并不会对作物造成化学伤害。

  公开号：

  US04378992A1

文献信息

• N'-Phenyl-N-methylurea derivatives, processes for their preparation and their uses as herbicides
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0017706A2

  公开（公告）日：1980-10-29

  Novel N'-phenyl-N-methylurea derivatives of the formula: wherein R is a C4-C10 cycloalkyl group, a C4-C10 cycloalkenyl group, a C4-C10 cycloalkyl group condensed with a benzene ring or substituted with at least one C1-C4 alkyl group or a C4-C,o cycloalkenyl group condensed with a benzene ring or substituted with a C1-C4 alkyl group, Z is a C1-C4 alkylene group which may have an atom of oxygen and/or sulfur at the terminal of and/or inside the carbon chain, Y is an oxygen atom or a sulfur atom, A is a hydrogen atom, a methyl group or a methoxy group and n is an integer of 0 or 1 with the profiso that in the chain consisting of -(Z)n-Y-, oxygen and/or sulfur atoms can not be present in succession, are described, which show pronounced herbicidal activity against a wide variety of weeds in the cultivation of crop plants without any material toxicity to mammals and any chemical injury to said crop plants. The preparation of the compounds and intermediates therefor and the herbicidal activity of the compounds are described and exemplified.

  式中的新型 N'-苯基-N-甲基脲衍生物： 其中 R 是 C4-C10 环烷基、C4-C10 环烯基、与苯环缩合或被至少一个 C1-C4 烷基取代的 C4-C10 环烷基或与苯环缩合或被 C1-C4 烷基取代的 C4-C,o 环烯基，Z 是 C1-C4 亚烷基，该亚烷基可在碳链的末端和/或碳链的内部具有氧原子和/或硫原子，Y 是氧原子或硫原子、A 是氢原子、甲基或甲氧基，n 是 0 或 1 的整数，但在由 -(Z)n-Y- 组成的链中，氧原子和/或硫原子不能连续存在。本文还描述并举例说明了这些化合物及其中间体的制备方法和除草活性。
• US4378992A
  申请人：——

  公开号：US4378992A

  公开（公告）日：1983-04-05
• Urea derivatives, and their production and use
  申请人：Sumitomo Chemical Company, Limited

  公开号：US04378992A1

  公开（公告）日：1983-04-05

  Novel N'-phenyl-N-methylurea derivatives of the formula: ##STR1## wherein R is a C.sub.4 -C.sub.10 cycloalkyl group, a C.sub.4 -C.sub.10 cycloalkenyl group, a C.sub.4 -C.sub.10 cycloalkyl group condensed with a benzene ring or substituted with at least one C.sub.1 -C.sub.4 alkyl group or a C.sub.4 -C.sub.10 cycloalkenyl group condensed with a benzene ring or substituted with a C.sub.1 -C.sub.4 alkyl group, Z is a C.sub.1 -C.sub.4 alkylene group which may have an atom of oxygen and/or sulfur at the terminal of and/or inside the carbon chain, Y is an oxygen atom or a sulfur atom, A is a hydrogen atom, a methyl group or a methoxy group and n is an integer of 0 or 1 with the proviso that in the chain consisting of --(Z).sub.n --Y--, oxygen and/or sulfur atoms can not be present in succession, which shows a pronounced herbicidal activity against a wide variety of weeds in the cultivation of crop plants without any material toxicity to mammals and any chemical injury to said crop plants.

  N'-苯基-N-甲基脲类化合物的新颖衍生物的化学式如下：其中R为C4-C10环烷基，C4-C10环烯基，与苯环融合的C4-C10环烷基或至少一个C1-C4烷基取代的C4-C10环烷基，或与苯环融合或取代一个C1-C4烷基的C4-C10环烯基；Z为C1-C4烷基链，端部和/或碳链内可能含有氧和/或硫原子；Y为氧原子或硫原子；A为氢原子，甲基基团或甲氧基团；n为0或1的整数，但在--(Z)n--Y--链中，氧和/或硫原子不得连续存在。这些衍生物对各种杂草显示出显著的除草活性，在种植作物的过程中对哺乳动物没有显著毒性，并不会对作物造成化学伤害。