5-chloro-6-methyl-2-(4-methylphenyl)-1H-benzimidazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 5-chloro-6-methyl-2-(4-methylphenyl)-1H-benzimidazole
• 化学式: C₁₅H₁₃ClN₂
• 分子量: 256.73
• InChiKey: PYVQPGRTOZMVEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  28.7
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Benzimidazole Compounds, Use As Inhibitors of WNT Signaling Pathway in Cancers, and Methods for Preparation Thereof
  申请人：Southern Research Institute

  公开号：US20170210741A1

  公开（公告）日：2017-07-27

  The present disclosure is concerned with benzimidazole compounds that are capable of inhibiting Wnt signaling and methods of treating disease states such as, for example, cancer, using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及能够抑制Wnt信号通路并用这些化合物治疗疾病状态（例如癌症）的苯并咪唑化合物及治疗方法。本摘要旨在作为特定领域搜索的扫描工具，不旨在限制本发明。