N¹,N¹-diisopropyl-N²-(diphenylphosphoryl)-2-methoxymethylacetamidine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹,N¹-diisopropyl-N²-(diphenylphosphoryl)-2-methoxymethylacetamidine
• 英文别名: N'-diphenoxyphosphoryl-3-methoxy-N,N-di(propan-2-yl)propanimidamide
• 化学式: C₂₂H₃₁N₂O₄P
• 分子量: 418.473
• InChiKey: IENXQCWIJAKUCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  叠氮磷酸二苯酯 、 二异丙胺 、 甲基炔丙基醚 在 copper(l) iodide 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以92%的产率得到N¹,N¹-diisopropyl-N²-(diphenylphosphoryl)-2-methoxymethylacetamidine
  参考文献：
  名称：

  Phosphoryl Azides as Versatile New Reaction Partners in the Cu-Catalyzed Three-Component Couplings

  摘要：

  [GRAPHICS]Phosphoryl azide was successfully employed as an efficient reacting partner in the Cu-catalyzed three-component reaction with 1-alkynes and amines to produce the corresponding phosphoryl amidines in high yields. A range of fruitful applicability of the produced amidines was also demonstrated such as an alkoxide exchange and asymmetric alpha-alkylation of optically active BINOL-derived amidines.

  DOI：

  10.1021/jo7016247

文献信息

• Phosphoryl Azides as Versatile New Reaction Partners in the Cu-Catalyzed Three-Component Couplings
  作者：Seok Hwan Kim、Doo Young Jung、Sukbok Chang

  DOI：10.1021/jo7016247

  日期：2007.12.1

  [GRAPHICS]Phosphoryl azide was successfully employed as an efficient reacting partner in the Cu-catalyzed three-component reaction with 1-alkynes and amines to produce the corresponding phosphoryl amidines in high yields. A range of fruitful applicability of the produced amidines was also demonstrated such as an alkoxide exchange and asymmetric alpha-alkylation of optically active BINOL-derived amidines.