(4-chloro-3-methoxyphenyl)(diphenyl)phosphine oxide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (4-chloro-3-methoxyphenyl)(diphenyl)phosphine oxide
• 英文别名: diphenyl-(4-chloro-3-methoxy-phenyl)-phosphine oxide；(4-chloro-3-methoxyphenyl)diphenylphosphine oxide；1-chloro-4-diphenylphosphoryl-2-methoxybenzene
• 化学式: C₁₉H₁₆ClO₂P
• 分子量: 342.762
• InChiKey: WALSTSOFDWJIBZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-溴-2-氯苯甲醚 、 二苯基次膦酰氯 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 生成 (4-chloro-3-methoxyphenyl)(diphenyl)phosphine oxide
  参考文献：
  名称：

  Bisphosphines as catalysts for asymmetric reactions

  摘要：

  本发明涉及手性纯的一般式(I)的双膦化合物，其中R在说明中定义，以及它们的制备过程和它们在金属络合物中作为不对称反应催化剂的用途，特别是不对称氢化反应。

  公开号：

  US05710339A1

文献信息

• Method of preparing organomagnesium compounds
  申请人：Ludwig-Maximilians-Universität München

  公开号：EP1582523A1

  公开（公告）日：2005-10-05

  The present invention is directed to a reagent for use in the preparation of organomagnesium compounds as well as to a method of preparing such organomagnesium compounds. The present invention furthermore provides a method of preparing functionalized or unfunctionalized organic compounds as well as the use of the reagents of the present invention in the preparation of organometallic compounds and their reaction with electrophiles. Finally, the present invention is directed to the use of lithium salts - LiY in the preparation of organometallic compounds and their reactions with electrophiles and to an organometallic compound which is obtainable by the disclosed method.

  本发明涉及一种试剂，用于制备有机镁化合物，以及一种制备这种有机镁化合物的方法。本发明还提供了一种制备官能化或非官能化有机化合物的方法，以及本发明的试剂在制备有机金属化合物及其与亲电试剂反应中的应用。最后，本发明涉及锂盐LiY在制备有机金属化合物及其与亲电试剂反应中的应用，以及通过所披露方法获得的有机金属化合物。
• Bisphosphines as catalysts for asymmetric reactions
  申请人：Bayer Aktiengesellschaft

  公开号：US05710339A1

  公开（公告）日：1998-01-20

  The invention relates to enantiomerically pure bisphosphines of the general formula (I) ##STR1## where R is as defined in the description, a process for their preparation and their use in metal complexes as catalysts for asymmetric reactions, in particular asymmetric hydrogenations.

  本发明涉及手性纯的一般式(I)的双膦化合物，其中R在说明中定义，以及它们的制备过程和它们在金属络合物中作为不对称反应催化剂的用途，特别是不对称氢化反应。
• Process for the preparation of enantiomerically pure (5, 5′-dichloro-6,6′-dimethoxy-biphenyl-2,2′-diyl)- bis(diphenylphosphine oxides)
  申请人：Bayer Aktiengesellschaft

  公开号：US06489513B2

  公开（公告）日：2002-12-03

  The invention relates to the preparation of enantiomerically pure bis-diphenylphosphine oxides in a particularly advantageous manner by (1) reacting an aromatic bromine compound with a diphenylphosphinic chloride in a mixture of tetrahydrofuran and an aromatic hydrocarbon to give a diphenylphosphine oxide, which is isolated from a solution in an aromatic hydrocarbon by adding a saturated aliphatic hydrocarbon; (2) metalating the resulting diphenylphosphine oxide in the 6-position and reacting the metalated diphenylphosphine oxide with iodine at temperatures not less than −25° C. in such a way that a small amount of iodine is always present in excess, giving a 2-iodo-diphenylphosphine oxide; (3) preparing a racemic bis-diphenylphosphine oxide from the resulting 2-iodo-diphenylphosphine oxide using copper and an aromatic hydrocarbon solvent and crystallizing the racemic bis-diphenylphosphine oxide from a solution in an aromatic hydrocarbon; and (4) separating isomers using an enantiomerically pure mono- or dicarboxylic acid to obtain a first enantiomer by crystallization from a solution in an aromatic hydrocarbon and obtaining a second enantiomer by hydrolysis and subsequent crystallization from a solution in an aromatic hydrocarbon.

  本发明涉及一种通过以下方式制备对映纯的双苯基膦氧化物的方法：(1)在四氢呋喃和芳香烃的混合物中，将芳香溴化合物与双苯基膦酸氯反应，得到双苯基膦氧化物，通过加入饱和脂肪烃从芳香烃中分离出来；(2)在6-位金属化所得的双苯基膦氧化物中，使用碘在不低于-25℃的温度下反应，使少量的碘始终过量存在，得到2-碘代双苯基膦氧化物；(3)使用铜和芳香烃溶剂从所得的2-碘代双苯基膦氧化物制备一个外消旋的双苯基膦氧化物，并通过从芳香烃中的溶液结晶来纯化；(4)使用对映纯的单羧酸或二羧酸分离异构体，通过从芳香烃中的溶液结晶来获得第一对映体，通过水解并随后从芳香烃中的溶液结晶来获得第二对映体。
• A LiCl-Mediated Br/Mg Exchange Reaction for the Preparation of Functionalized Aryl- and Heteroarylmagnesium Compounds from Organic Bromides
  作者：Arkady Krasovskiy、Paul Knochel

  DOI：10.1002/anie.200454084

  日期：2004.6.21
• US5710339A
  申请人：——

  公开号：US5710339A

  公开（公告）日：1998-01-20