2-(4-(2-methyl-4-oxo-1-phenyl-1,2-dihydroquinazolin-3(4H)-yl)phenoxy)acetic acid

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-(4-(2-methyl-4-oxo-1-phenyl-1,2-dihydroquinazolin-3(4H)-yl)phenoxy)acetic acid
• 英文别名: 2-[4-(2-methyl-4-oxo-1-phenyl-2H-quinazolin-3-yl)phenoxy]acetic acid
• 化学式: C₂₃H₂₀N₂O₄
• 分子量: 388.423
• InChiKey: VNIOKEDWBOQFQO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  70.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-苯基邻氨基苯甲酸 在 potassium acetate 、 potassium carbonate 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.0h， 生成 2-(4-(2-methyl-4-oxo-1-phenyl-1,2-dihydroquinazolin-3(4H)-yl)phenoxy)acetic acid
  参考文献：
  名称：

  Design, synthesis and in vivo screening of some novel quinazoline analogs as anti-hyperlipidemic and hypoglycemic agents

  摘要：

  A novel series of substituted quinazoline derivatives were designed, synthesized and evaluated for their hypolipidemic activity in cholesterol induced hyperlipidemic rats. In vivo screening concluded that compounds A-4, C-5 and C-6 have shown potent antihyperlipidemic activity by decreasing the plasma level of triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL), followed by increase in level of high density lipoprotein (HDL). (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2015.12.037

文献信息

• Design, synthesis and in vivo screening of some novel quinazoline analogs as anti-hyperlipidemic and hypoglycemic agents
  作者：Santosh N. Mokale、Akash D. Palkar、Pritam N. Dube、Nikhil S. Sakle、Pankaj B. Miniyar

  DOI：10.1016/j.bmcl.2015.12.037

  日期：2016.1

  A novel series of substituted quinazoline derivatives were designed, synthesized and evaluated for their hypolipidemic activity in cholesterol induced hyperlipidemic rats. In vivo screening concluded that compounds A-4, C-5 and C-6 have shown potent antihyperlipidemic activity by decreasing the plasma level of triglycerides (TG), very low density lipoprotein (VLDL), low density lipoprotein (LDL), followed by increase in level of high density lipoprotein (HDL). (C) 2015 Elsevier Ltd. All rights reserved.