2-methyl-pyrrolidine-1-carboxamidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 2-methyl-pyrrolidine-1-carboxamidine
• 英文别名: 2-Methyl-pyrrolidin-1-carbamidin；2-Methylpyrrolidine-1-carboximidamide
• 化学式: C₆H₁₃N₃
• 分子量: 127.189
• InChiKey: MFKFBXHKYFTAMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  氰胺 、 2-甲基吡咯烷 生成 2-methyl-pyrrolidine-1-carboxamidine
  参考文献：
  名称：

  DE537302

  摘要：

  公开号：

文献信息

• Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors
  申请人：FEDORA PHARMACEUTICALS INC.

  公开号：US10030019B2

  公开（公告）日：2018-07-24

  A compound of formula (I): wherein: M is hydrogen or a pharmaceutically acceptable salt-forming cation; Y is OR1 or NR2R3, and R1, R2, R3 and M are as defined herein. Also, methods of treating bacterial infection, pharmaceutical compositions, molecular complexes and processes for preparing compounds.

  式 (I) 的化合物： 其中 M 是氢或药学上可接受的成盐阳离子； Y 是 OR1 或 NR2R3、 以及 R1、R2、R3 和 M 如本文所定义。此外，还有治疗细菌感染的方法、药物组合物、分子复合物和制备化合物的工艺。
• METHODS FOR TREATING MICROGLIAL DYSFUNCTION
  申请人：Washington University

  公开号：US20210393563A1

  公开（公告）日：2021-12-23

  Among the various aspects of the present disclosure is the provision of methods of treating a microglial dysfunction-associated diseases, disorder, and conditions. The present disclosure provides for a method for treating microglial dysfunction in a subject having a microglial dysfunction-associated neurodegenerative disease comprising administering to a subject a therapeutically effective amount of a microglial rescuing agent. The present disclosure also provides for a method of reversing neuronal damage in a subject having a microglial dysfunction-associated neurodegenerative disease, wherein the microglial dysfunction-associated neurodegenerative disease is characterized by a single nucleotide polymorphisms (SNPs) or mutation in Trem2 or ApoE affecting microglial functions.
• DE537302
  申请人：——

  公开号：——

  公开（公告）日：——