2-(aziridin-1-yl)-1-(4-chlorophenyl)ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(aziridin-1-yl)-1-(4-chlorophenyl)ethanol
• 化学式: C₁₀H₁₂ClNO
• 分子量: 197.664
• InChiKey: JMJHQDAAGIRFJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  23.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (±)-4-氯苯乙烯环氧化物 、 2-氯乙胺盐酸盐 在 sodium hydroxide 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 12.0h， 以83%的产率得到2-(aziridin-1-yl)-1-(4-chlorophenyl)ethanol
  参考文献：
  名称：

  Regioselective Synthesis of N-β-Hydroxyethylaziridines by the Ring-Opening Reaction of Epoxides with Aziridine Generated in Situ

  摘要：

  Biologically important N-beta-hydroxyethylaziridine intermediates were conveniently prepared by regioselective ring-opening reactions of diversely substituted epoxides. Ethyleneimine generated in situ under basic conditions from beta-chloroethylamine was used as a nucleophile to open the epoxides in an aqueous environment.

  DOI：

  10.1021/ol0529703

文献信息

• Regioselective Synthesis of <i>N</i>-β-Hydroxyethylaziridines by the Ring-Opening Reaction of Epoxides with Aziridine Generated in Situ
  作者：Ha Young Kim、Arindam Talukdar、Mark Cushman

  DOI：10.1021/ol0529703

  日期：2006.3.1

  Biologically important N-beta-hydroxyethylaziridine intermediates were conveniently prepared by regioselective ring-opening reactions of diversely substituted epoxides. Ethyleneimine generated in situ under basic conditions from beta-chloroethylamine was used as a nucleophile to open the epoxides in an aqueous environment.