N,N-dipropylpyridin-3-amine

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N,N-dipropylpyridin-3-amine
• 化学式: C₁₁H₁₈N₂
• 分子量: 178.277
• InChiKey: XOSGUOVEQHJCJR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  16.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3-氯吡啶 、 二正丙胺 在 potassium carbonate 、 (2S)-1-((11bR)-dinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-yl)-8-(diphenylphosphino)-2-(naphthalen-1-yl)-1,2,3,4-tetrahydroquinoline 、 palladium dichloride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.16h， 以96%的产率得到N,N-dipropylpyridin-3-amine
  参考文献：
  名称：

  Synthesis of a Sensitive and Selective Potassium-Sensing Fluoroionophore

  摘要：

  An efficient synthesis Is reported that delivers in 5 steps and 52% overall yield a new structurally simplified fluorescent K+ sensor with Improved K+ sensitivity and selectivity over existing K+ sensors. The synthesis procedure utilizes a new template-directed oxidative C-N bond-forming macrocyclization reaction and reports new approaches to Pd(0), Sandmeyer-like and metal-free aminoarylations, as well as organotitanlum additions to vinylogous sulfonates.

  DOI：

  10.1021/ol902836c

文献信息

• Vinter-Pasquier, Karine; Jamart-Gregoire, Brigitte; Caubere, Paul, Heterocycles, 1997, vol. 45, # 11, p. 2113 - 2129
  作者：Vinter-Pasquier, Karine、Jamart-Gregoire, Brigitte、Caubere, Paul

  DOI：——

  日期：——
• Synthesis of a Sensitive and Selective Potassium-Sensing Fluoroionophore
  作者：Richard D. Carpenter、A. S. Verkman

  DOI：10.1021/ol902836c

  日期：2010.3.19

  An efficient synthesis Is reported that delivers in 5 steps and 52% overall yield a new structurally simplified fluorescent K+ sensor with Improved K+ sensitivity and selectivity over existing K+ sensors. The synthesis procedure utilizes a new template-directed oxidative C-N bond-forming macrocyclization reaction and reports new approaches to Pd(0), Sandmeyer-like and metal-free aminoarylations, as well as organotitanlum additions to vinylogous sulfonates.