(E)-[5]-shogaol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: (E)-[5]-shogaol
• 英文别名: 1-(4-hydroxy-3-methoxy-phenyl)-non-4-en-3-one；1-(4-Hydroxy-3-methoxy-phenyl)-non-4-en-3-on；(E)-1-(4-hydroxy-3-methoxyphenyl)non-4-en-3-one
• 化学式: C₁₆H₂₂O₃
• 分子量: 262.349
• InChiKey: NJMQENFOGOPOEK-VOTSOKGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  姜酮 在 4-甲基苯磺酸吡啶 、 对甲苯磺酸 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 、 苯 为溶剂， 反应 2.0h， 生成 (E)-[5]-shogaol
  参考文献：
  名称：

  Side-chain length is important for shogaols in protecting neuronal cells from β-amyloid insult

  摘要：

  Ten shogaols were synthesized to evaluate the importance of the side-chain length in protecting cells from betaA(1-42) insult using PC12 rat pheochromocytoma and IMR-32 human neuroblastoma cells. The compounds cell protectivity against betaA insult was demonstrated using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) reduction assay. The efficacy of cell protection from betaA insult by these shogaols was shown to improve as the length of the side chain increase. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2003.12.041

文献信息

• PHOTOPROTECTIVE COMPOSITION BASED ON A 2-ALKOXY-4-ALKYL KETONE PHENOL COMPOUND; USE OF SAID COMPOUND FOR INCREASING THE SUN PROTECTION FACTOR
  申请人：L'OREAL

  公开号：EP3281620A1

  公开（公告）日：2018-02-14

  The present invention relates to a fluid composition intended for protecting the skin and/or hair against ultraviolet radiation, characterized by the fact that it comprises, in a cosmetically acceptable aqueous support, at least: (a) one photoprotective system capable of screening out UV radiation; and (b) one 2-alkoxy-4-alkyl ketone phenol compound. The present invention also relates to the use of a 2-alkoxy-4-alkyl ketone phenol compound in a composition comprising, in a cosmetically acceptable medium, at least one photoprotective system capable of screening out UV radiation.

  本发明涉及一种用于保护皮肤和/或头发免受紫外线辐射的流体组合物，其特征在于，该组合物在化妆品可接受的水性支持物中至少包括 (a) 一种能屏蔽紫外线辐射的光保护系统；和 (b) 一种 2-烷氧基-4-烷基酮酚化合物。 本发明还涉及 2-烷氧基-4-烷基酮酚化合物在组合物中的使用，该组合物包含在化妆品可接受的介质中的至少一种能够屏蔽紫外线辐射的光保护体系。
• COMPOSITION, USE, AND PRESERVATION METHOD
  申请人：Dalko Maria

  公开号：US20120269739A1

  公开（公告）日：2012-10-25

  The invention relates to a cosmetic, pharmaceutical, dermatological, nutraceutical or oral cosmetic composition having, as main preserving system, a mild preserving system formed from compounds with a broad antimicrobial spectrum, which have only one pKa, the said pKa being greater than or equal to 10, the said mild preserving system being present in a content strictly greater than or equal to 1% by weight relative to the weight of the said composition. The invention also relates to the use, in a cosmetic, dermatological or pharmaceutical composition, of at least one compound of formula (I), as a preserving agent:
• US8765101B2
  申请人：——

  公开号：US8765101B2

  公开（公告）日：2014-07-01
• US9358192B2
  申请人：——

  公开号：US9358192B2

  公开（公告）日：2016-06-07
• [EN] PHOTOPROTECTIVE COMPOSITION BASED ON A 2-ALKOXY-4-ALKYL KETONE PHENOL COMPOUND; USE OF SAID COMPOUND FOR INCREASING THE SUN PROTECTION FACTOR<br/>[FR] COMPOSITION PHOTOPROTECTRICE À BASE DE COMPOSÉ 2-ALCOXY-4-ALKYLCÉTONEPHÉNOL ; UTILISATION DUDIT COMPOSÉ POUR AUGMENTER LE FACTEUR DE PROTECTION SOLAIRE
  申请人：OREAL

  公开号：WO2011042358A1

  公开（公告）日：2011-04-14

  The present invention relates to a fluid composition intended for protecting the skin and/or hair against ultraviolet radiation, characterized by the fact that it comprises, in a cosmetically acceptable aqueous support, at least: (a) one photoprotective system capable of screening out UV radiation; and (b) one 2-alkoxy-4-alkyl ketone phenol compound. The present invention also relates to the use of a 2-alkoxy-4-alkyl ketone phenol compound in a composition comprising, in a cosmetically acceptable medium, at least one photoprotective system capable of screening out UV radiation.